DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Cb and pcdh1g18

DIOPT Version :9

Sequence 1:	NP_001287524.1	Gene:	Cad96Cb / 43033	FlyBaseID:	FBgn0039294	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001019288.2	Gene:	pcdh1g18 / 554005	ZFINID:	ZDB-GENE-050609-13	Length:	934	Species:	Danio rerio

Alignment Length:	604	Identity:	144/604 - (23%)
Similarity:	242/604 - (40%)	Gaps:	123/604 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 SFLATEDLAVGSIIGKLRINGDANAETGDINLSLREKNAPVEIHPGTK---ELALSVELDKEGVR 102
            |...:||.|.|::|..:.:....:.:...|:.|: :.|:|.:|.....   .|....|||:|
Zfish   353 SSAVSEDAAPGTVIAMINVQDLDSGDNSKISCSI-DLNSPFKIISSLTNYYNLVTDSELDRE--- 413

  Fly   103 GPSSIYVNVICIRRHSTDPSFVIP--VNVRVTDVNDNAPQWIGTPYTLTLSEVTVPGTRILQGAR 165
              .:...|:........:|...:.  :|::::||||:|||::...|...::|...|.|.||. .:
Zfish   414 --QTAEYNITITAVDGGNPPLSVKEILNLKISDVNDHAPQFVQESYNAFIAENNPPSTTILT-VK 475

  Fly   166 AEDADQPGPFSTVEYQVLP-----GPYSEYVQFLNPLEGTLVLKKALDYEQLQNFTVKLRAQDQG 225
            |||.|. ||.:.|.|.::.     .|.:.|:. :|...|.:..:|:.|||||::|.::::|||.|
Zfish   476 AEDMDW-GPNAKVSYFLIDADLNGAPLASYIS-INSESGVVYAEKSFDYEQLKSFKMQVKAQDGG 538

  Fly   226 TPPRHSDTLLRVVITDADDQNPKF-----QRESYSAEI-PADGRPGELRMRPEPLKAVDQDEGIC 284
            :||..|:..|.::|.|.:|..|:.     ...|..||| |.....|.|..:   :.|||.|.|..
Zfish   539 SPPLSSNVTLNIIIQDQNDNAPQVLYPVQTGASVVAEIVPRAADVGYLVTK---VVAVDVDSGQN 600

  Fly   285 APIQYTIVQSQDAKYFRIHPHNGAISLLTPIGYAD-VANGATLVVKATQIDN--PDRYALTTVQL 346
            |.:.|.:.::.|...|.:...||.|..:..:...| |....|:||:    ||  |.|.|:.::.:
Zfish   601 AWLSYKLQKAADRALFEVGLQNGEIRTVRQVTDKDAVKQKLTVVVE----DNGQPSRSAVVSINV 661

  Fly   347 ----------------TRPGSHSDLST------LAFVQKRFVMRIREDTAVGNRILALPTN---- 385
                            |....::|..|      ||.|...|::.|....:|  :|.....|
Zfish   662 AVADSFPEVLSEFTDFTHEKQYNDNLTFYLVLALAVVSLLFIVSIISIISV--KIYRWRQNKLFY 724

  Fly   386 KPGKHLKYVIP--DPVNSQFFSVGSL----------------GELVLAKPLDYEKM-TKHEFQVL 431
            |.|.:|. |||  .||    ::.|:|                .::...:|.....: ::.....:
Zfish   725 KSGANLP-VIPYYPPV----YADGTLQHVYNYEMCGTTDSRMSDVKFVRPYSQNTLVSQSRVGTV 784

  Fly   432 ATDGMTNSTAELTLEVIDVN-DWEPRFRETHYEFMVPKSSLQSRADSFEGVLIG----------- 484
            ..:.......|||||....| ||  ||............:....|.:..||:.|
Zfish   785 QRERKEQEVDELTLEQKPPNTDW--RFPPNQRPGPSGAGARPEEAGAGAGVIAGTGPWPNPPTEA 847

  Fly   485 -KVEAADGDRNDKLELSLRGQHAGL-FEIDSTGNIYM---------RPEQLQSLNESTVHLIAIA 538
             :::|.....|.....:..|....| :..|...|:|:         .|:| |.|.:      |:.
Zfish   848 EQLQAMMAAANASEATATLGPRYNLQYGPDYRQNVYIPGSTATLTANPQQ-QVLQQ------ALP 905

  Fly   539 TDTGVP----PRSTSVPVS 553
            ....:|    |::...|.|
Zfish   906 PPQALPPTEAPKAAQTPAS 924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Cb	NP_001287524.1	Cadherin_repeat	46..137	CDD:206637	21/95 (22%)
		Cadherin_repeat	145..244	CDD:206637	35/103 (34%)
		Cadherin_repeat	253..347	CDD:206637	29/113 (26%)
		Cadherin_repeat	365..452	CDD:206637	22/110 (20%)
		Cadherin_repeat	461..555	CDD:206637	20/119 (17%)
pcdh1g18	NP_001019288.2	Cadherin_2	31..113	CDD:311943
		Cadherin_repeat	142..239	CDD:206637
		Cadherin_repeat	247..343	CDD:206637
		Cadherin_repeat	356..448	CDD:206637	21/97 (22%)
		Cadherin_repeat	456..558	CDD:206637	35/104 (34%)
		Cadherin_repeat	577..665	CDD:206637	25/94 (27%)
		Cadherin_C_2	686..766	CDD:318652	19/86 (22%)
		Cadherin_tail	801..920	CDD:318236	23/127 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	130	1.000	Inparanoid score	I4620
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.050