DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad96Cb and Pcdh12

DIOPT Version :9

Sequence 1:	NP_001287524.1	Gene:	Cad96Cb / 43033	FlyBaseID:	FBgn0039294	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_059074.2	Gene:	Pcdh12 / 53601	MGIID:	1855700	Length:	1180	Species:	Mus musculus

Alignment Length:	927	Identity:	210/927 - (22%)
Similarity:	327/927 - (35%)	Gaps:	253/927 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 FLATEDLAVGSIIGK----LRINGDANAETGDINLSLREKNA-PVEIHPGTKELALSVELDKEGV 101
            |..||::..|::|||    ||:. :...:.||....|:...| ||:::.....|:.|..||:|.:
Mouse    34 FQVTEEVPSGTVIGKLSQELRVE-ERRGKAGDAFQILQLPQALPVQMNSEDGLLSTSSRLDREKL 97

  Fly   102 ---RGPSSIYVNVICIRRHSTDPSFVIPVNVRVTDVNDNAPQWIGTPYTLTLSEVTVPGTRILQG 163
               ..|..:..:|:     :|..|.:|.|.::|.|:||:.||:......|.:||.....|||...
Mouse    98 CRQEDPCLVSFDVL-----ATGASALIHVEIQVLDINDHQPQFPKDEQELEISESASLHTRIPLD 157

  Fly   164 ARAEDADQPGPFSTVEYQVLPGPYSEYVQFLNPLE---GTLVLKKALDYEQLQNFTVKLRAQDQG 225
             ||.|.| .||.|...|.:.|..:......:.|.|   ..||:.|.||.|....|.:.|.|.|.|
Mouse   158 -RALDQD-TGPNSLYSYSLSPSEHFALDVIVGPDETKHAELVVVKELDRELHSYFDLVLTAYDNG 220

  Fly   226 TPPRHSDTLLRVVITDADDQNPKFQRESYSAEIPADGRPGELRMRPEPLKAVDQDEGICAPIQYT 290
            .||:...::::|.:.|::|.:|.|...|.:.|||.|..||.|.:.   |.|.|.|:|....:::.
Mouse   221 NPPKSGISVVKVNVLDSNDNSPVFAESSLALEIPEDTVPGTLLIN---LTATDPDQGPNGEVEFF 282

  Fly   291 I---VQSQDAKYFRIHPHNGAISLLTPIGY-------ADV------------------------- 320
            .   |..:....|.|....|.|.|...:.|       .||
Mouse   283 FGKHVSPEVMNTFGIDAKTGQIILRQALDYEKNPAYEVDVQARDLGPNSIPGHCKVLIKVLDVND 347

  Fly   321 ---------ANGATLV------------VKATQID-----------------------NPDRYAL 341
                     |:..:||            |.|..:|                       |.:.|.|
Mouse   348 NAPSILITWASQTSLVSEDLPRDSFIALVSANDLDSGNNGLVHCWLNQELGHFRLKRTNGNTYML 412

  Fly   342 TTVQLTRPGSHSDLSTL-AFVQKR-------------FVMRIREDTAVGNR----ILALPTNKPG 388
            .| ..|.......:.|| .|.|.:             .|..:.::..|..:    :.....|.|.
Mouse   413 LT-NATLDREQWPIYTLTVFAQDQGPQPLSAEKELQIQVSDVNDNAPVFEKSRYEVSTWENNPPS 476

  Fly   389 KHL----------------KYVIPD-PVNSQFFSVGSLGELVLAKPLDYEKMTKHEFQVLATD-G 435
            .||                .|.|.| ||:.........||:...:.||||:|...||||:|.| |
Mouse   477 LHLITLKAHDADLGSNGKVSYRIKDSPVSHLVIIDFETGEVTAQRSLDYEQMAGFEFQVIAEDRG 541

  Fly   436 MTN--STAELTLEVIDVNDWEPRFRETHYEFMVP-----KSSLQSRADSFEGVLIGKVE------ 487
            ...  |:..:.:.::|.||..|       |.:.|     |::|....::..|.|:..:|
Mouse   542 QPQLASSISVWVSLLDANDNAP-------EVIQPVLSEGKATLSVLVNASTGHLLLPIENPSGMD 599

  Fly   488 -------------------------AADGDRNDKLELSLR-GQHAGLFEID-STGNIYMRPEQLQ 525
                                     .||...|.:|..|:: |..|.||.:. |.|.:::......
Mouse   600 PAGTGIPPKATHSPWSFLLLTIVARDADSGANGELFYSIQSGNDAHLFFLSPSLGQLFINVTNAS 664

  Fly   526 SLNESTVHLIAIATDTGVPPRSTSVPVSV----TMEGL--TLARSGWNSN----------MLGMF 574
            ||..|...|..:..|.|.|...|.|.:.|    :::.|  :....|..|.          :|.:|
Mouse   665 SLIGSQWDLGIVVEDQGSPSLQTQVSLKVVFVTSVDHLRDSAHEPGVLSTPALALICLAVLLAIF 729

  Fly   575 GMIMGLFLMIIVALSCYIVRSKKQGKSASSGLGLGRNR-VHSQAHSSVSSANLV----THE---- 630
            |:::.||:.|     |...|...:..:........|:: ...|.|...:..:||    .||
Mouse   730 GLLLALFVSI-----CRTERKDNRAYNCREAESSYRHQPKRPQKHIQKADIHLVPVLRAHENETD 789

  Fly   631 --KLAGNGNGNGASVTSGGVSVL----HMKHGGNITMANPMNNGLHHVASGASSSMALGSSAALL 689
              :.:.........:.:|..|.|    |:......|:.|..|.|            .|..|..:|
Mouse   790 EVRPSHKDTSKETLMEAGWDSCLQAPFHLTPTLYRTLRNQGNQG------------ELAESQEVL 842

  Fly   690 E----------RERERERDRERQRESYAATVRIFL-----PGI-VSRASANGQLFEEDEIEHDSL 738
            :          |:|...|:.....||..|..:..|     ||. ::||:.:....|..:....|.
Mouse   843 QDTFNFLFNHPRQRNASRENLNLPESPPAVRQPLLRPLKVPGSPIARATGDQDKEEAPQSPPASS 907

  Fly   739 QT----ENNNRKVAATG 751
            .|    .|.|.||:..|
Mouse   908 ATLRRQRNFNGKVSPRG 924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Cb	NP_001287524.1	Cadherin_repeat	46..137	CDD:206637	27/98 (28%)
		Cadherin_repeat	145..244	CDD:206637	32/101 (32%)
		Cadherin_repeat	253..347	CDD:206637	32/172 (19%)
		Cadherin_repeat	365..452	CDD:206637	27/110 (25%)
		Cadherin_repeat	461..555	CDD:206637	28/135 (21%)
Pcdh12	NP_059074.2	E_set	32..111	CDD:298831	21/77 (27%)
		Cadherin_repeat	139..240	CDD:206637	32/102 (31%)
		Cadherin_repeat	251..348	CDD:206637	21/99 (21%)
		Cadherin_repeat	363..456	CDD:206637	14/93 (15%)
		Cadherin_repeat	465..561	CDD:206637	26/95 (27%)
		Cadherin_repeat	617..693	CDD:206637	20/75 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	857..930		17/68 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	973..1026
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1076..1104
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1156..1180
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	136	1.000	Inparanoid score	I4532
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050