DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Cb and pcdh1a4

DIOPT Version :9

Sequence 1:	NP_001287524.1	Gene:	Cad96Cb / 43033	FlyBaseID:	FBgn0039294	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001019270.1	Gene:	pcdh1a4 / 497127	ZFINID:	ZDB-GENE-050202-4	Length:	941	Species:	Danio rerio

Alignment Length:	706	Identity:	169/706 - (23%)
Similarity:	287/706 - (40%)	Gaps:	166/706 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 SFLATEDLAVGSIIGKLRINGDANAETGDINLSLRE-KNAPVEIHPG-----------TKELALS 93
            |:..:|:...|::||.:         ..|:.:|.:| ::...:|.||           |..|.:.
Zfish    26 SYSVSEEANKGTVIGNI---------AKDLKISAQELESRMFQIMPGLNAKYFDVNVKTGSLFVK 81

  Fly    94 VELDKEGVRGPSSIYVNVIC---IRRHSTDPSFVIPVNVRVTDVNDNAPQWIGTPYTLTLSEVTV 155
            ..:|:|.:.|     ||..|   :...:.:|..:..:.:.:.|||||||.:..:.|.|:::|..:
Zfish    82 DRIDREELCG-----VNQKCALNLEALAQNPHRLYRLEIVIVDVNDNAPVFPNSTYILSVTENAI 141

  Fly   156 PGTRILQGARAEDADQPGPFSTVEYQ----------VLPGPYSEYVQFLNPLEGTLVLKKALDYE 210
            .|.|..... |:|.| .|..:..:|:          |..|..|.|.:        |:|:||||.|
Zfish   142 EGDRFPLPV-AKDLD-VGSNALKDYKLSSNEHFSLDVHSGQRSIYAE--------LILQKALDRE 196

  Fly   211 QLQNFTVKLRAQDQGTPPRHSDTLLRVVITDADDQNPKFQRESYSAEIPADGRPGELRMRPEPLK 275
            :.....:.|.|.|.|.||:.....:.|.:.|.:|..|.|.:..|..::..:...|   .:...:.
Zfish   197 KQAVIHLILTAIDGGKPPKSGTLSIVVNVKDINDNKPVFSKSLYKVKVKENTPVG---TKIISVS 258

  Fly   276 AVDQDEGICAPIQYTIV---QSQDAKYFRIHPHNGAISLLTPIGYADVANGATLVVKATQIDNPD 337
            |.|.||||.:.|||:.:   .:.:...|.|:.::|.|::...|.:.: .:...|.|:|:...:|.
Zfish   259 ARDLDEGINSEIQYSFLGHGNNDELNRFTINTNSGEITVQGQIDHEE-DSAIELRVQASDKGSPS 322

  Fly   338 R--YALTTVQLTRPGSHS-DLSTLAFVQKRFVMRIREDTAVGNRILALPT---NKPGKH------ 390
            :  :....:::.....:: ::.|...::.     ::||...|..: ||.|   ...||:
Zfish   323 KSTHCKVLIEVVDENDNAPEIVTTPLMES-----VKEDAKSGTAV-ALVTVSDKDMGKNGILHCA 381

  Fly   391 LKYVIPDPVNSQFFSVGSLGELVLAKPLDYEKMTKHEFQVLATDGMT---NSTAELTLEVIDVND 452
            ||...|..:.:.:.:..|   ||:..|||.|.::::...:.|.|..|   :|:..:|:.:.||||
Zfish   382 LKGSFPFKLETSYNNHYS---LVVDGPLDRESVSQYNITITAADEGTPPLSSSTVITVHISDVND 443

  Fly   453 WEPRFRETHYEFMVPKSSLQSRADSFEGVLIGKVEAADGDRNDKLELS---LRGQHAG-----LF 509
            ..|     |:...|..:.|...:.:  |.|:.||.|.|.|..:..|||   |....:.     |.
Zfish   444 NAP-----HFSAPVINAFLSENSQA--GGLVTKVTADDSDTGENAELSYSLLDSSSSSIPVTTLI 501

  Fly   510 EIDS-TGNIYMRPEQLQSLN-EST--VHLIAIATDTGVPPRST---------------------- 548
            .|:| :|.|:    .|||.| |.|  .....:||||||||.|:
Zfish   502 NINSLSGEIF----SLQSFNHEETKRFQFQVMATDTGVPPLSSNATVNVFILDENDNSPVILAPY 562

  Fly   549 SVPVSVTMEGLTL---------------ARSGWNSNMLGMFGMIMGLFLMIIVALSCYIVRSKKQ 598
            |.|.||..|.:..               |.||:|                   ||..|.:...|.
Zfish   563 SEPGSVNTENIPYSAEAGYFVAKIRAVDADSGYN-------------------ALLSYHLTEPKG 608

  Fly   599 GKSASSGLGLGRNRVHSQAHSSVSSANLVTHEKL---AGNGNGNGASVTSGGVSVL 651
            ......|...|..|...:    :|..:|.||.::   :.||..:.::.||..|.||
Zfish   609 TNLFRIGSSTGEIRTKRR----MSDNDLKTHPQIITVSENGEPSLSATTSMDVVVL 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Cb	NP_001287524.1	Cadherin_repeat	46..137	CDD:206637	22/105 (21%)
		Cadherin_repeat	145..244	CDD:206637	29/108 (27%)
		Cadherin_repeat	253..347	CDD:206637	20/98 (20%)
		Cadherin_repeat	365..452	CDD:206637	25/98 (26%)
		Cadherin_repeat	461..555	CDD:206637	37/127 (29%)
pcdh1a4	NP_001019270.1	Cadherin_2	24..106	CDD:285466	19/93 (20%)
		Cadherin_repeat	131..231	CDD:206637	29/109 (27%)
		Cadherin_repeat	240..339	CDD:206637	20/102 (20%)
		Cadherin_repeat	351..444	CDD:206637	26/101 (26%)
		Cadherin_repeat	452..554	CDD:206637	33/107 (31%)
		Cadherin_repeat	572..660	CDD:206637	20/110 (18%)
		Cadherin_C_2	682..754	CDD:293101
		Cadherin_tail	790..912	CDD:292596
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	130	1.000	Inparanoid score	I4620
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.050