DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Cb and pcdh2ab10

DIOPT Version :9

Sequence 1:	NP_001287524.1	Gene:	Cad96Cb / 43033	FlyBaseID:	FBgn0039294	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001009589.2	Gene:	pcdh2ab10 / 493598	ZFINID:	ZDB-GENE-041118-9	Length:	940	Species:	Danio rerio

Alignment Length:	724	Identity:	181/724 - (25%)
Similarity:	293/724 - (40%)	Gaps:	136/724 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WIYYAILSLCWFNKATLGAILDSRCYLEGGGSAESFLATE-DLAVGSIIGK-LRINGDANAETGD 69
            ||::::...||.  .|.|.|:.|.......|:|...||.: :|.|..|..: .:|..::|....|
Zfish    12 WIFFSVFLCCWI--FTNGQIVYSISEEANPGTAVGNLAKDFNLNVQDIERRGFQIVSESNKRYFD 74

  Fly    70 INLSLREKNAPVEIHPGTKELALSVELDKEGVRG--PSSIYVNVICIRRHSTDPSFVIPVNVRVT 132
            .|.    |...:.:    ||.....||.::.::.  |....||         .|..|....:.|.
Zfish    75 FNF----KTGVLHV----KERIDREELCEQKIKCSLPLEAIVN---------SPLNVFRFEINVL 122

  Fly   133 DVNDNAPQWIGTPYTLTLSEVTVPGTRILQGARAEDADQPGPFSTVEYQVLPGP-YSEYVQF--L 194
            |:|||.|::.....|:.:||..:||.:....: |.||| .|..|...|::.|.. :|..||.  .
Zfish   123 DINDNPPKFRTPKTTINISESALPGEQFALPS-AFDAD-VGINSVKSYKLSPNEHFSLDVQSGGE 185

  Fly   195 NPLEGTLVLKKALDYEQLQNFTVKLRAQDQGTPPRHSDTLLRVVITDADDQNPKFQRESYSAEIP 259
            ..:...|||:||||.|:.....:.|.|.|.|.|.|.....:.|.:.|.:|..|.|.:..|.|.:.
Zfish   186 QSVSAELVLQKALDREKQPLIRLTLTAVDGGKPLRSGTMQITVHVEDVNDNIPVFSKSLYKARVN 250

  Fly   260 ADGRPGELRMRPEPLKAVDQDEGICAPIQYTIV---QSQDAKYFRIHPHNGAISLLTPIGYADVA 321
            .:..||...:   .::|.|.|||:...|.|.:|   ..::.:.|.|:|..|.|::...:.| :..
Zfish   251 ENAPPGTSII---TVQASDPDEGVNGQIVYALVNHDNDRNVESFAINPETGEITVKGDVDY-ERK 311

  Fly   322 NGATLVVKATQIDNPDRYALTTVQLTRPGSHSDLSTLAFVQKRFVMRIRE----DTAVGNRILAL 382
            |...|.|:|....:..|.||..|.|.....:.::..::...  .|..::|    ||.||  ::.:
Zfish   312 NAVELRVQAKDKGHKPRAALCKVLLEIIDVNDNVPEISVTS--LVNTVKEDALIDTVVG--MITV 372

  Fly   383 PTNKPGKHLKYVIPDPVNSQF---FSVGSLGELVLAKPLDYEKMTKHEFQVLATDGMT---NSTA 441
            ..|..||:.:.::....:|.|   .|..:...|.:..|||.|:.:::...:.|.|..|   :||:
Zfish   373 TDNDAGKNGQVILNIQGSSPFKVQNSYKNYYTLFVNGPLDRERASEYNVTISAADEGTPPLSSTS 437

  Fly   442 ELTLEVIDVNDWEPRFRETHYEFMVPKSSLQSRADSFEGVLIGKVEAADGDRNDK-------LEL 499
            .:.:.|.||||..|||.|       |..::..:.:|..|.::..|.|.|.|..|.       ||.
Zfish   438 VIAVHVSDVNDNAPRFPE-------PVINVYVKENSQIGAVLHTVSAVDPDVGDNARITYSLLES 495

  Fly   500 SLRGQHAGLFEIDS-TGNIYMRPEQLQSLNESTVHLIAI---ATDTGVPPRSTSVPV-------- 552
            |..|....:..|:| ||:::    .|||.|...:.....   |||:||||.|::|.|
Zfish   496 SKSGPVTSMININSDTGDLH----SLQSFNYEEIKTFEFKVQATDSGVPPLSSNVTVNVFVLDEN 556

  Fly   553 --------------SVTMEGLTL---------------ARSGWNSNMLGMFGMIMGLFLMIIVAL 588
                          ||..|.:..               |.||:|                   ||
Zfish   557 DNSPAILAPYSELGSVNTENIPYSAEAGYFVAKIRAVDADSGYN-------------------AL 602

  Fly   589 SCYIVRSKKQGKSASSGLGLGRNRVHSQAHSSVSSANLVTHE---KLAGNGNGNGASVTSGGVSV 650
            ..|.:...|.......|...|..|...:    :|..:|.||.   .:..||..:.::..|  :..
Zfish   603 LSYHISEPKGNNLFRIGTSSGEIRTKRR----MSDNDLKTHPLVVLVCDNGEPSLSATVS--IDA 661

  Fly   651 LHMKHGGNI 659
            :.::.||::
Zfish   662 VVVESGGDV 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Cb	NP_001287524.1	Cadherin_repeat	46..137	CDD:206637	20/94 (21%)
		Cadherin_repeat	145..244	CDD:206637	32/101 (32%)
		Cadherin_repeat	253..347	CDD:206637	26/96 (27%)
		Cadherin_repeat	365..452	CDD:206637	25/96 (26%)
		Cadherin_repeat	461..555	CDD:206637	31/126 (25%)
pcdh2ab10	NP_001009589.2	Cadherin_2	28..109	CDD:311943	19/88 (22%)
		Cadherin_repeat	137..236	CDD:206637	32/100 (32%)
		Cadherin_repeat	245..344	CDD:206637	27/102 (26%)
		Cadherin_repeat	356..449	CDD:206637	25/94 (27%)
		Cadherin_repeat	457..558	CDD:206637	29/104 (28%)
		Cadherin_repeat	576..659	CDD:206637	18/107 (17%)
		Cadherin_C_2	686..758	CDD:318652
		Cadherin_tail	795..912	CDD:318236
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	130	1.000	Inparanoid score	I4620
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.050