DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Cb and pcdh2ab1

DIOPT Version :9

Sequence 1:	NP_001287524.1	Gene:	Cad96Cb / 43033	FlyBaseID:	FBgn0039294	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001009588.2	Gene:	pcdh2ab1 / 493589	ZFINID:	ZDB-GENE-041118-1	Length:	941	Species:	Danio rerio

Alignment Length:	731	Identity:	175/731 - (23%)
Similarity:	281/731 - (38%)	Gaps:	182/731 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 YLEGGGSAE-SFLATEDLAVGSIIGKLRINGDANAETGDINLSLRE-KNAPVEIHPGTKELALSV 94
            ||....||: |:...|::..|:.:|.|         ..|||||::| ::....|..|:|:...||
Zfish    20 YLSKTASAQISYNVLEEVKPGTTVGNL---------AKDINLSVKELQSRGFRIVSGSKKQYFSV 75

  Fly    95 ELD------------KEGVRGPSSIYVNVICIRRHSTDPSFVIPVNVRVTDVNDNAPQWIGTPYT 147
            .:|            :|...|..:..||:..:   ...|..:..|.:.:.|:|||:|.:..:...
Zfish    76 NVDTGALQVSERIDREELCAGAVACSVNLEAV---VNSPLQLYRVRINILDINDNSPVFPTSSVV 137

  Fly   148 LTLSEVTVPGTRI-LQGARAEDADQPGPFSTVEYQVLPGPY---SEYVQFLNPLEGTLVLKKALD 208
            :.:||.|.||.|. |:.  |.||| .|..|...|::....|   .........:...|||:||||
Zfish   138 INVSESTAPGVRFPLES--AHDAD-IGVNSVKTYKLATNDYFSLDMQTHTDKTISAELVLQKALD 199

  Fly   209 YEQLQNFTVKLRAQDQGTPPRHSDTLLRVVITDADDQNPKFQRESYSAEIPADGRPGELRMRPEP 273
            .|:.......:.|.|.|:|.|....::.|.:.|.:|..|.|.:..|...:......|....|
Zfish   200 REKTPRLEFTVTAFDGGSPARTGTVMIEVNVLDINDHAPVFSKTLYKVSVAEHALVGTAVAR--- 261

  Fly   274 LKAVDQDEGICAPIQYTIVQ--SQDAK-YFRIHPHNGAISLLTPIGYAD---------------- 319
            |:|.|.|||:.|.|.|:.|.  :|:.: .|.|...:|.:.:...|.|.:
Zfish   262 LQARDLDEGLNAEIVYSFVDRTAQNIREKFEIDAQSGDVKIKGDIDYEESTAFEIRVQATDKGQV 326

  Fly   320 VANGAT-LVVKATQI-DNPDRYALTTVQLTRPGSHSDLSTLAFVQKRFVMRIREDTAVGNRILAL 382
            ..:|.| |:::...: |||.  .:|...|..|                   :.|:...|..|..:
Zfish   327 TMSGHTKLLIEVLDVNDNPP--DVTVTSLLSP-------------------VEENAGRGTVIALM 370

  Fly   383 PTNKP--GKH------LKYVIPDPVNSQFFSVGSLGELVLAKPLDYEKMTKHEFQVLATDGMTNS 439
            ..:.|  ||:      |....|..:.|.|.:..|   |||...||.|.:|::...|:|.|..:.|
Zfish   371 TVSDPDSGKNGAVHVRLSGFNPFKLQSSFQNYYS---LVLDGVLDRENVTEYNVTVIAEDEGSPS 432

  Fly   440 TAE---LTLEVIDVNDWEPRFRET-HYEFMVPKSSLQSRADSFEGVLIGKVEAADGDRNDKLELS 500
            .:.   :.:||.||||..|||..: .|.::        |.:|..|.:|..:.|:|.|..|...|:
Zfish   433 MSRVKVIRVEVSDVNDNAPRFASSVEYAYL--------RENSNVGTVIMTLTASDADIRDNAHLT 489

  Fly   501 ---LRGQHAG-----LFEIDS-TGNIYMRPEQLQSLNESTVHLIAI---ATDTGVPPRSTSVPV- 552
               |:....|     |.:::| ||.|    |.:.:.:...:.....   |||:||||.|::|.|
Zfish   490 YSLLQSSVGGTPISALLKVNSLTGEI----ESMLTFDYEEIKTFEFKVQATDSGVPPLSSNVTVN 550

  Fly   553 ---------------------SVTMEGLTL---------------ARSGWNSNMLGMFGMIMGLF 581
                                 ||..|.:..               |.||:|
Zfish   551 VFVLDENDNSPAILAPYSELGSVNTENIPYSAEAGYFVAKIRAVDADSGYN-------------- 601

  Fly   582 LMIIVALSCYIVRSKKQGKSASSGLGLGRNRVHSQAHSSVSSANLVTHE---KLAGNGNGNGASV 643
                 ||..|.:...|.......|...|..|...:    :|..:|.||.   .:..||..:.::.
Zfish   602 -----ALLSYHISEPKGNNLFRIGTSSGEIRTKRR----MSDNDLKTHPLVILVCDNGEPSLSAT 657

  Fly   644 TSGGVSVLHMKHGGNI 659
            .|  :..:.::.||::
Zfish   658 VS--IDAVVVESGGDV 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Cb	NP_001287524.1	Cadherin_repeat	46..137	CDD:206637	24/103 (23%)
		Cadherin_repeat	145..244	CDD:206637	30/102 (29%)
		Cadherin_repeat	253..347	CDD:206637	26/114 (23%)
		Cadherin_repeat	365..452	CDD:206637	26/97 (27%)
		Cadherin_repeat	461..555	CDD:206637	29/127 (23%)
pcdh2ab1	NP_001009588.2	Cadherin_2	28..109	CDD:311943	21/92 (23%)
		Cadherin_repeat	135..236	CDD:206637	30/103 (29%)
		Cadherin_repeat	245..344	CDD:206637	22/101 (22%)
		Cadherin_repeat	357..449	CDD:206637	27/94 (29%)
		Cadherin_repeat	459..559	CDD:206637	28/111 (25%)
		Cadherin_repeat	577..660	CDD:206637	18/107 (17%)
		Cadherin_C_2	687..759	CDD:318652
		Cadherin_tail	796..913	CDD:318236
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	130	1.000	Inparanoid score	I4620
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.050