DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Cb and Pcdhgb8

DIOPT Version :9

Sequence 1:	NP_001287524.1	Gene:	Cad96Cb / 43033	FlyBaseID:	FBgn0039294	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001032236.1	Gene:	Pcdhgb8 / 364845	RGDID:	1307432	Length:	929	Species:	Rattus norvegicus

Alignment Length:	750	Identity:	173/750 - (23%)
Similarity:	300/750 - (40%)	Gaps:	187/750 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 GSAES--FLATEDLAVGSIIGKLRINGDANAETGDI---NLSLREKNAPVEIHPGTKELALSVEL 96
            |.||.  :...|::|:||::|.|.  .|......|:   ||.:..:...:.::|....:.:|.::
  Rat    28 GLAEQVRYSIPEEMAMGSVVGNLA--EDLGLPVQDLLIRNLRVISEKPYLTVNPENGNIVVSDKI 90

  Fly    97 DKEGVRGPSSIYVNVICIRRHSTDPSFVIPVNVRVTDVNDNAPQWIGTPYTLTLSEVTVPGTRI- 160
            |:|.:...|.:.  |:.:...:.:|..|..|:|.:.|:|||.|:::.....|.::|..:||||.
  Rat    91 DRELLCFQSPLC--VLPLEIVAENPLNVFHVSVVIEDINDNPPRFLQNRIVLQINEFAIPGTRFG 153

  Fly   161 LQGARAEDADQPGPFSTVEYQV-LPGPYSEYVQFLNPLEG----TLVLKKALDYEQLQNFTVKLR 220
            |:.  |.||| .||.|...||: |...:|..|:  :..||    .|||:|.||.|:..:..:.|.
  Rat   154 LES--AIDAD-VGPNSLQSYQLSLNEHFSLVVK--DKTEGKDAPELVLEKPLDREKQSSQLLVLT 213

  Fly   221 AQDQGTPPRHSDTLLRVVITDADDQNPKFQRESYSAEIPADGRPGELRMRPEPLKAVDQDEGICA 285
            |.|.|.|.......:::.:|||:|..|.|.:.:|...:..:...|...:   .:.|.|.|||:.|
  Rat   214 AVDGGEPVLTGTAQIQIEVTDANDNPPVFSQSTYKVSLRENMPSGTSVL---TVMATDPDEGVNA 275

  Fly   286 PIQYTIVQ-SQD--AKYFRIHPHNGAISLLTPIGY---------ADVANGATLVVKATQI----- 333
            .|.|:... .:|  :|:...| .:|.|....||.:         .:..:|..:..:...:
  Rat   276 EITYSFKSLGEDIRSKFILDH-QSGEIKSKGPIDFEARRTYTMNIEAKDGGGMATECKVVIEILD 339

  Fly   334 --DNPDRYALTTVQLTRPGSHSDLSTLAFVQKRFVMRIREDTAVGNRILALPT-----NKPGK-- 389
              ||......|:|      |:|               |.||...|..:....|     .:.|:
  Rat   340 ENDNAPEVVFTSV------SNS---------------ITEDAEPGTVVALFKTYDKDAEENGRVS 383

  Fly   390 -HLKYVIPDPVNSQFFSVGSLGELVLAKPLDYEKMTKHEFQVLATD----GMTNSTAELTLEVID 449
             .:|..:|..:.|   |..:..:||....||.|:..::...::|||    .:::||: :||.|.|
  Rat   384 CFVKETVPFRIES---SASNYYKLVTDGILDREQTPEYNVTIVATDKGKPSLSSSTS-VTLHVGD 444

  Fly   450 VNDWEPRFRETHYEFMVPKSSLQSRADSFEGVLIGKVEAADGDRNDKLELSLRGQHAGLFEIDST 514
            |||..|.|.:..|...|.:::.       .|..|.:|.|:|.|                  :.|.
  Rat   445 VNDNAPVFHQASYLIQVAENNP-------PGASIAQVSASDPD------------------LGSN 484

  Fly   515 GNIYMRPEQLQSLNESTVHLIAIATDTGVPPRSTSVPVSVTME-GLTLARSGWNSNMLGMFGMIM 578
            |               .:....||:|  :.|:|....|||..: |:..|:..::...|..|.:.:
  Rat   485 G---------------LISYSIIASD--LEPKSLWSYVSVNRDSGVVFAQRAFDHEQLRSFQLTL 532

  Fly   579 GLFLMIIVALSCYIVRSKKQGKSASSGLGLGRNRVHSQAHSSVSSANLVTHEKLAGNGNGNGASV 643
                           :::.||                   |...||| |:...|.|:.|.|...|
  Rat   533 ---------------QARDQG-------------------SPALSAN-VSMRVLVGDRNDNAPRV 562

  Fly   644 -----TSGGVSVLHM-----KHGGNIT--MANPMNNG-----LHHVASGASSSM-ALG------- 683
                 ...|.::..|     :.|..:|  :|...::|     .:||...:...: :||
  Rat   563 LYPALEPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASDPGLFSLGLRTGEVR 627

  Fly   684 SSAALLERERERER----DRERQRESYAATVRIFL 714
            ::.||.:|:..|:|    .|:..:...:||..:.|
  Rat   628 TARALGDRDSARQRLLVAVRDGGQPPLSATATLHL 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Cb	NP_001287524.1	Cadherin_repeat	46..137	CDD:206637	22/93 (24%)
		Cadherin_repeat	145..244	CDD:206637	36/104 (35%)
		Cadherin_repeat	253..347	CDD:206637	22/112 (20%)
		Cadherin_repeat	365..452	CDD:206637	25/98 (26%)
		Cadherin_repeat	461..555	CDD:206637	17/93 (18%)
Pcdhgb8	NP_001032236.1	Cadherin_2	32..112	CDD:285466	16/83 (19%)
		Cadherin_repeat	138..238	CDD:206637	36/104 (35%)
		Cadherin_repeat	246..343	CDD:206637	18/100 (18%)
		Cadherin_repeat	355..448	CDD:206637	27/111 (24%)
		Cadherin_repeat	456..558	CDD:206637	32/178 (18%)
		Cadherin_repeat	578..662	CDD:206637	16/83 (19%)
		Cadherin_C_2	687..769	CDD:293101
		Cadherin_tail	806..>902	CDD:292596
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	130	1.000	Inparanoid score	I4545
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050