DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad96Cb and Pcdh7

DIOPT Version :9

Sequence 1:	NP_001287524.1	Gene:	Cad96Cb / 43033	FlyBaseID:	FBgn0039294	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	XP_038948108.1	Gene:	Pcdh7 / 360942	RGDID:	1303209	Length:	1271	Species:	Rattus norvegicus

Alignment Length:	987	Identity:	206/987 - (20%)
Similarity:	336/987 - (34%)	Gaps:	352/987 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ILSLCWFNKATLGAILDSRCYLEGGGSAESFLATEDLAVGSIIGKLRI-NGDANAETGDINLSLR 75
            :|.|| |:.|....:|..|...||         ..|:.:|::...|.| .|     :|::..||.
  Rat    20 LLPLC-FSLAAAKQLLRYRLAEEG---------PADVRIGNVASDLGIVTG-----SGEVTFSLE 69

  Fly    76 EKNAPVEIHPGTKELALSV-ELDKE--------------------GVRGPSSIYVNVICIRRHST 119
            ..:..::|...|.||:.|. .:|:|                    .|.|||..:|::...|
  Rat    70 SGSEYLKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGR---- 130

  Fly   120 DPSFVIPVNVRVTDVNDNAPQWIGTPYTLTLSEVTVPGTRIL----------------------- 161
                     |.|.|:|||.|.:.....|||:.|....||..|
  Rat   131 ---------VIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEP 186

  Fly   162 -------QGAR---AEDADQP-------------------------------GPFSTVEYQVLPG 185
                   :|.|   |:.|..|                               |..|..|.||...
  Rat   187 GGGGGGGEGRRLGPADSAPYPGGGGNSGSGGGSGGSKRRLDAPEGGGGTGPSGRSSVFELQVADT 251

  Fly   186 PYSEYVQFLNPLEGTLVLKKALDYEQLQNFTVKLRAQDQGTPPRHSDTLLRVVITDADDQNPKFQ 250
            |..|       .:..|::|.|||.||..::.:.||.:|.|.|||.|..:|||:|||.:|.:|:|:
  Rat   252 PDGE-------KQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFE 309

  Fly   251 RESYSAEIPADGRPGELRMRPEPLKAVDQDEGICAPIQYTIVQSQDA--KYFRIHPHNGAISLL- 312
            :..|.|::..:..||...::   |:|.|.|.|:...|:|....:.::  :..|:...:|.:|:|
  Rat   310 KSVYEADLAENSAPGTPILQ---LRATDLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLH 371

  Fly   313 ----------------------------------------------------------------- 312

  Rat   372 RIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDV 436

  Fly   313 ---TPIGYADVAN---GATLVVKATQI----------------DNPDRYALTT-----VQLTR-- 348
               |||....|::   |...||..|.:                .|..:|.|.|     .:.||
  Rat   437 LVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSAPLDYETTREF 501

  Fly   349 --------PGSHSDLSTLAFVQK------------RFVMRI--REDTAVGNRI-LALPTN-KPGK 389
                    .||.|..|..:.|.|            :.|:.:  .|:...|.|: ..|.|: ..||
  Rat   502 NVVIVAVDSGSPSLSSNNSLVVKVGDTNDNPPVFGQSVVEVYFPENNIPGERVATVLATDADSGK 566

  Fly   390 H--LKYVIPDPVNSQFFSVGSLGELVLAKPLDYEKMTKHEFQVLATD---GMTNSTAELTLEVID 449
            :  :.|.:...|...|......|::::...||.|:..::||:|.|.|   .:...:..:.::|.|
  Rat   567 NAEIAYSLDSSVMGTFAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQGSTTVIVQVAD 631

  Fly   450 VNDWEPRFRETHYEFMVPKSSLQSRADSFEGVLIGKVEAADGDRNDKLELSLR-GQHAGLFEIDS 513
            .||.:|:|.:..:.|.| |.:||..:.      :|.|...|.|:....|:||. .:::.:|.|::
  Rat   632 KNDNDPKFMQDVFTFYV-KENLQPNSP------VGMVTVMDADKGRNAEMSLYIEENSNIFSIEN 689

  Fly   514 -TGNIYMRPEQLQSLNESTVHLIAIATDTGVPPRSTSVPVSVTMEGLTLARSGWNSNMLGMFGMI 577
             ||.|| ........:::|......|.|.|.||||.:..||
  Rat   690 DTGTIY-STMSFDREHQTTYTFRVKAVDGGDPPRSATATVS------------------------ 729

  Fly   578 MGLFLMIIVALSCYIVRSKKQGKSASSGLGLGRNRVHSQAHSSVSSANLVTHEKLAGNGNGNGAS 642
              ||:|             .:..:|.: :.|.||..::....|.:...:|.......:.:|..|.
  Rat   730 --LFVM-------------DENDNAPT-VTLPRNISYTLLPPSSNVRTVVATVLATDSDDGINAD 778

  Fly   643 V-----------------TSGGVSVLHMKHGGNITMANPMNNGLHHVASGASSSMALGSSAALLE 690
            :                 |||.||::     |.:|.   .:.|||.:.
  Rat   779 LNYSIVGGNPFKLFEIDSTSGVVSLV-----GKLTQ---KHYGLHRLV----------------- 818

  Fly   691 RERERERDRERQRESYAATVRIFLPGIVSRASA-NGQLFEE------DEIEHDSLQTENNNRKVA 748
               .:..|..:..:|....|.:|:...||.|:. :.|:...      .:|..|.....:..|...
  Rat   819 ---VQVNDSGQPSQSTTTLVHVFVNESVSNATVIDSQIVRSLHTPLTQDIAGDPSYEISKQRLSI 880

  Fly   749 ATGVASGGVTTI 760
            ..||.:|.:|.|
  Rat   881 VIGVVAGIMTVI 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Cb	NP_001287524.1	Cadherin_repeat	46..137	CDD:206637	25/112 (22%)
		Cadherin_repeat	145..244	CDD:206637	40/162 (25%)
		Cadherin_repeat	253..347	CDD:206637	27/188 (14%)
		Cadherin_repeat	365..452	CDD:206637	22/95 (23%)
		Cadherin_repeat	461..555	CDD:206637	28/95 (29%)
Pcdh7	XP_038948108.1	Cadherin_repeat	35..139	CDD:206637	28/130 (22%)
		Cadherin_repeat	147..304	CDD:206637	40/163 (25%)
		Cadherin_repeat	312..411	CDD:206637	15/101 (15%)
		Cadherin_repeat	429..531	CDD:206637	20/101 (20%)
		Cadherin_repeat	541..635	CDD:206637	22/93 (24%)
		Cadherin_repeat	643..738	CDD:206637	31/141 (22%)
		Cadherin_repeat	749..839	CDD:206637	17/117 (15%)
		Protocadherin	842..1053	CDD:400603	12/51 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	130	1.000	Inparanoid score	I4545
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050