DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad96Cb and Pcdhac1

DIOPT Version :9

Sequence 1:	NP_001287524.1	Gene:	Cad96Cb / 43033	FlyBaseID:	FBgn0039294	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001003671.1	Gene:	Pcdhac1 / 353236	MGIID:	1891442	Length:	964	Species:	Mus musculus

Alignment Length:	608	Identity:	149/608 - (24%)
Similarity:	246/608 - (40%)	Gaps:	140/608 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LCWFNKATLGAILDSRCYLEGGGSAESFLATE---DLAVGSIIGKLRINGDANAETGDINLSL-- 74
            |||:  .:.||         ..|..|..:..|   .:.||:|...|:::...        |||
Mouse     9 LCWW--VSCGA---------AAGQLEYSVLEETEPGVTVGNIASDLKLSAAV--------LSLRN 54

  Fly    75 -------REKNAPVEIHPGT---KELALSVELDKEGVRGPSSIYVNVICIRRHS---TDPSFVIP 126
                   ||....|::..|:   :|||     |:|.:     ......||..:.   .||..:..
Mouse    55 FRFLSNYRESYFGVDLGSGSLVVQELA-----DREQL-----CPAKASCILTYELMFEDPLELHK 109

  Fly   127 VNVRVTDVNDNAPQWIGTPYTLTLSEVTVPGTRILQGARAEDADQPGPFSTVEYQVLPGPY---- 187
            :.|.:.|.|||:|.:......|.:.|...||.|.:. ..|:|||: |....:.|.:....:
Mouse   110 IRVHLLDTNDNSPLFPAGDVHLHIPEFLPPGARFIL-PNAQDADE-GSNGALSYSLSISQHFRLD 172

  Fly   188 -------SEYVQFLNPLEGTLVLKKALDYEQLQNFTVKLRAQDQGTPPRHSDTLLRVVITDADDQ 245
                   |:|.:        |||:||||.||.....:.|.|||.|.|.|.....:.:.:.|.:|.
Mouse   173 MGSRVDGSKYPE--------LVLEKALDREQRDTHLLVLTAQDGGLPARSGAAQVTITVVDTNDN 229

  Fly   246 NPKFQRESYSAEIPADGRPGELRMRPEPLKAVDQDEGICAPIQYTIVQSQDAK---YFRIHPHNG 307
            .|.|:...||.::|.....|.:...   ::|:|.|||....:.|::..|..|:   .|.:||.:|
Mouse   230 APVFEHSVYSTKVPETAPNGTVLFH---VQALDPDEGSNGEVWYSLSNSTPAELRHLFHVHPKSG 291

  Fly   308 AISLLTPIGYADVANGATLVVKATQIDNPDRYALTT-----VQLTRPGSHS---DLSTLAFVQKR 364
            .:.:...:|..:     ||:....:..:...::|.:     |::|....|:   |..|
Mouse   292 EVQVAASLGPPE-----TLLEAFVEARDEGAFSLASTTKLLVEVTDVNDHAPQMDFMT------- 344

  Fly   365 FVMRIREDTAVGNRILALPTNKP---GKHLKYVIPDPVNSQF---FSVGSLGELVLAKPLDYEKM 423
            |...|.||.|.|. ::||.:.|.   |.:.|..........|   .|..|...|:...|||.|:.
Mouse   345 FSSSILEDAAPGT-VIALLSVKDEDLGSNGKVTCSMSSKGPFQLKASFDSYYRLLTDGPLDREQA 408

  Fly   424 TKHEFQVLATDGMT---NSTAELTLEVIDVNDWEPRFRETHYEFMVPKSSLQSRADSFEGVLIGK 485
            ::::..:.|:||.:   ::...||:.|.||||..|.|.:...|..|.:       ::..||.:|.
Mouse   409 SEYQILISASDGGSPPLSTRRTLTVSVADVNDNTPNFPQPQQELFVAE-------NNSPGVSLGG 466

  Fly   486 VEAADGDR--------------NDKLELSLRGQHAGLFEID-STGNIYMRP----EQLQSLNEST 531
            |.|.|.|.              ::::.:|     :.|..:: :||.|..:.    |||:..|...
Mouse   467 VFAQDPDLGENGFVFYELLDVISERMPVS-----SSLVAVEPTTGVITAKTSFDFEQLRGFNFQV 526

  Fly   532 VHLIAIATDTGVPPRSTSVPVSV 554
            .     ..|.|:||||.:|.|::
Mouse   527 E-----GRDGGIPPRSATVTVNL 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Cb	NP_001287524.1	Cadherin_repeat	46..137	CDD:206637	24/108 (22%)
		Cadherin_repeat	145..244	CDD:206637	30/109 (28%)
		Cadherin_repeat	253..347	CDD:206637	21/101 (21%)
		Cadherin_repeat	365..452	CDD:206637	27/95 (28%)
		Cadherin_repeat	461..555	CDD:206637	26/113 (23%)
Pcdhac1	NP_001003671.1	E_set	21..103	CDD:298831	20/99 (20%)
		Cadherin_repeat	130..229	CDD:206637	30/108 (28%)
		Cadherin_repeat	237..336	CDD:206637	22/106 (21%)
		Cadherin_repeat	344..441	CDD:206637	29/104 (28%)
		Cadherin_repeat	451..552	CDD:206637	26/111 (23%)
		Cadherin_repeat	570..653	CDD:206637
		Cadherin_tail	813..956	CDD:292596
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	136	1.000	Inparanoid score	I4532
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050