DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Cb and Pcdhb4

DIOPT Version :9

Sequence 1:	NP_001287524.1	Gene:	Cad96Cb / 43033	FlyBaseID:	FBgn0039294	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001108073.1	Gene:	Pcdhb4 / 291655	RGDID:	1308912	Length:	779	Species:	Rattus norvegicus

Alignment Length:	774	Identity:	186/774 - (24%)
Similarity:	283/774 - (36%)	Gaps:	192/774 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 GGSAESFLATEDLAVGSIIGKLRINGDANAETGDINLSLREKNAPVEIHPGTKELA--------- 91
            |..|..:...|:...|.::..|.  .|.....|:    |..:.|.:. |.|.|||.
  Rat    27 GSEAIKYSMPEETESGYLVANLA--KDLGLRVGE----LATRGARIH-HRGNKELLQLDAETGNL 84

  Fly    92 -LSVELDKE---GVRGPSSIYVNVICIRRHSTDPSFVIPVNVRVTDVNDNAPQWIGTPYTLTLSE 152
             |..:||:|   |:..|..:...:|.     .:|.......:::||:||:||::..|...||:.|
  Rat    85 FLKEKLDREVLCGLTEPCVLQFQIIL-----KNPVQFFQTELQLTDINDHAPEFPDTEMLLTIPE 144

  Fly   153 VTVPGTRILQGARAEDADQPGPFSTVEYQVLPGPYSEYVQFLNPLEG----TLVLKKALDYEQLQ 213
            ...||| :.....|:|:| .|..:...|.|.|..:...|.. :..:|    .|||.:|||.|:..
  Rat   145 SVQPGT-VFPLKAAQDSD-IGSNAVQNYTVSPNLHFHVVTH-SRTDGRKYPELVLDRALDREEQP 206

  Fly   214 NFTVKLRAQDQGTPPRHSDTLLRVVITDADDQNPKFQRESYSAEIPADGRPGELRMRPEPLKAVD 278
            ..|:.|.|.|.|.|.|...|.:.:.:.|.:|..|:|.:..|..::| :..|  |......:.|.|
  Rat   207 ELTLILTALDGGAPRRSGMTAVHIEVVDINDNAPQFVQSLYEVQVP-ENIP--LDALVVTVSATD 268

  Fly   279 QDEGICAPIQYTIVQ-SQDAKYFRIHPHNGAISL-------LTPIGYADVA--NGATLVVKAT-- 331
            .|.||...:.|::.| |:|::.|.|....|.|.|       :||....::|  :|..|..|.|
  Rat   269 LDAGIYGNVAYSLFQGSRDSQPFIIDEITGEIRLSKELDFEVTPYYNVEIAAVDGGGLSGKCTVA 333

  Fly   332 -QI----DNPDRYALTTVQLTRPGSH--------------------------------------- 352
             |:    ||.....::|.....|.:.
  Rat   334 VQVLDVNDNAPELTISTFSSPVPENSPETVVLVFGVFDQDSGDNGRMVCSIQNELPFLLKSTFEN 398

  Fly   353 ------------------------SDLST--------------------LAFVQKRFVMRIREDT 373
                                    |||.|                    .:|.|..:.|.:.|:.
  Rat   399 YYTLVTERPLDRESRAEYNITITVSDLGTPRLTTQHTITVKVSDINDNAPSFTQTSYTMFVHENN 463

  Fly   374 AVGNRI--LALPTNKPGK--HLKYVI--PDPVNSQFFSVGSL----GELVLAKPLDYEKMTKHEF 428
            :....|  ::...:..|.  |:.|.:  ||.......|:.|:    |:|...:.||||.:...||
  Rat   464 SPALHIGTISATDSDSGSNAHITYSLLPPDDPQLDLDSLISINADNGQLFALRALDYEALQSFEF 528

  Fly   429 QVLATD---GMTNSTAELTLEVIDVNDWEPRFRETHYEFMVPKSSLQSRADSFEGVLIGKVEAAD 490
            .|.|||   ...:|.|.:.:.|:|.||..|...........|.:.|..|| :..|.|:.||.|.|
  Rat   529 LVGATDEGSPALSSQALVHVVVLDDNDNVPFVLYPLQNASPPCTELLPRA-AEPGYLVTKVVAVD 592

  Fly   491 GDRNDKLELS---LRGQHAGLFEIDSTGNIYMRPEQLQSLNESTVH-LIAIATDTGVPPRSTSVP 551
            .|......||   |:....|||.: ...|..:|..:|.|..:...| |:.:..|.|.|.||.||.
  Rat   593 QDSGQNAWLSFQLLKATEPGLFSV-WAHNGEVRTARLLSERDVPKHKLLLLVKDNGEPQRSASVT 656

  Fly   552 VSVTMEGLTLARSGWNSNMLGMFGMIM-------GLFLMIIVALSCYIVRSKKQGKSASS----- 604
            :.|      |...|::...|.:..:.:       .|.|.::|||:           |.||
  Rat   657 LHV------LLVDGFSQPYLPLPEVALDPTYDEDNLTLYLVVALA-----------SVSSLFLLS 704

  Fly   605 -----GLGLGRN-RVHSQAHSSVSSANLVTHEKLAGNGNGNGASVTSGGVSVLHMKHGG 657
                 |:.|.|. |..|....||...:|.:|   ..|.:|.|....|....|..|...|
  Rat   705 VLLFVGVRLCRRARASSLGGYSVPEGHLPSH---LVNVSGMGTLSQSYQYEVCLMGESG 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Cb	NP_001287524.1	Cadherin_repeat	46..137	CDD:206637	23/103 (22%)
		Cadherin_repeat	145..244	CDD:206637	31/102 (30%)
		Cadherin_repeat	253..347	CDD:206637	29/110 (26%)
		Cadherin_repeat	365..452	CDD:206637	26/99 (26%)
		Cadherin_repeat	461..555	CDD:206637	30/97 (31%)
Pcdhb4	NP_001108073.1	Cadherin_2	31..112	CDD:285466	19/92 (21%)
		Cadherin_repeat	140..238	CDD:206637	31/100 (31%)
		Cadherin_repeat	247..342	CDD:206637	26/97 (27%)
		Cadherin_repeat	355..446	CDD:206637	5/90 (6%)
		Cadherin_repeat	454..556	CDD:206637	27/101 (27%)
		Cadherin_repeat	575..663	CDD:206637	30/95 (32%)
		Cadherin_C_2	685..768	CDD:293101	24/90 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	130	1.000	Inparanoid score	I4545
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050