Protein Alignment Cad96Cb and PCDHB5

DIOPT Version :9

• Sequence 1: NP_001287524.1
• Gene: Cad96Cb / 43033
• FlyBaseID: FBgn0039294
• Length: 789
• Species: Drosophila melanogaster
• Sequence 2: NP_056484.2
• Gene: PCDHB5 / 26167
• HGNCID: 8690
• Length: 795
• Species: Homo sapiens
• Alignment Length: 700
• Identity: 165/700 - (23%)
• Similarity: 255/700 - (36%)
• Gaps: 200/700 - (28%)

  Fly     6 QWIYYAILSLCWFNKATLGAILDSRCYLEGGGSAESFLATE-------------DLAVGSIIGKL 57
            |.::.|||.|.|                |.|..|..:...|             ||.:|  :|:|
Human    13 QVMFLAILLLLW----------------EAGSEAVRYSIPEETESGYSVANLAKDLGLG--VGEL 59

  Fly    58 RINGDANAETGDINLSLREKNAPVEIHPGTKELALSVELDKE---GVRGPSSIYVNVICIRRHST 119
            ...|......|:..|        :::...|..|.|..:||:|   |...|..::..::.     .
Human    60 ATRGARMHYKGNKEL--------LQLDIKTGNLLLYEKLDREVMCGATEPCILHFQLLL-----E 111

  Fly   120 DPSFVIPVNVRVTDVNDNAPQWIGTPYTLTLSEVTVPGTRILQGARAEDADQPGPFSTVEYQVLP 184
            :|......::::||:||:||::......|.:.|.|.||| :.....|:|.| .|..:...|.:.|
Human   112 NPVQFFQTDLQLTDINDHAPEFPEKEMLLKIPESTQPGT-VFPLKIAQDFD-IGSNTVQNYTISP 174

  Fly   185 GPYSEYVQFLNPLEG----TLVLKKALDYEQLQNFTVKLRAQDQGTPPRHSDTLLRVVITDADDQ 245
            ..:. :|...|..:|    .|||.||||.|:....::.|.|.|.|.|||...|.:|:|:.|.:|.
Human   175 NSHF-HVATHNRGDGRKYPELVLDKALDREERPELSLTLTALDGGAPPRSGTTTIRIVVLDNNDN 238

  Fly   246 NPKFQRESYSAEIPADGRPGELRMRPEPLKAVDQDEGICAPIQYTIVQSQD-------------- 296
            .|:|.:..|..::|.:.....|.:   .:.|.|.|.|....:.|.:.|..:
Human   239 APEFLQSFYEVQVPENSPLNSLVV---VVSARDLDAGAYGSVAYALFQGDEVTQPFVIDEKTAEI 300

  Fly   297 ----AKYFRIHPH---------NGAIS--LLTPIGYADVANGA------TL-----------VVK 329
                |..|...|:         .|.:|  ....|...||.:.|      ||           ||.
Human   301 RLKRALDFEATPYYNVEIVATDGGGLSGKCTVAIEVVDVNDNAPELTMSTLSSPTPENAPETVVA 365

  Fly   330 ATQIDNPDR-------------------------YALT---------------TVQLTRPGS--- 351
            ...:.:||.                         |.|.               |:.:|..|:
Human   366 VFSVSDPDSGDNGRMICSIQNDLPFLLKPTLKNFYTLVTQRTLDRESQAEYNITITVTDMGTPRL 430

  Fly   352 ---H------SDL--STLAFVQKRFVMRIREDTAVGNRILALPTNKPGKHL-------------- 391
               |      ||:  :..||.|..:.:.:||:            |.|..|:
Human   431 KTEHNITVLVSDVNDNAPAFTQTSYTLFVREN------------NSPALHIGSVSATDRDSGTNA 483

  Fly   392 --KYVIPDPVNS--QFFSVGSL----GELVLAKPLDYEKMTKHEFQVLATD---GMTNSTAELTL 445
              .|.:..|.|.  :..|:.|:    |.|...:.||||.:...||:|.|||   ...:|.|.:.:
Human   484 QVTYSLLPPQNPHLRLASLVSINADNGHLFALRSLDYEALQAFEFRVGATDRGSPALSSEALVRV 548

  Fly   446 EVIDVNDWEPRFRETHYEFMVPKSSLQSRADSFEGVLIGKVEAADGDRNDKLELS---LRGQHAG 507
            .|:|.||..|...........|.:.|..|| :..|.|:.||.|.|||......||   |:....|
Human   549 LVLDANDNSPFVLYPLQNGSAPCTELVPRA-AEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPG 612

  Fly   508 LFEIDSTGNIYMRPEQLQSLNESTVH-LIAIATDTGVPPRSTSVPVSVTM 556
            ||.: ...|..:|..:|.|..::..| |:.:..|.|.||||.:..:.|.:
Human   613 LFSM-WAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLL 661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Cb	NP_001287524.1	Cadherin_repeat	46..137	CDD:206637	21/106 (20%)
		Cadherin_repeat	145..244	CDD:206637	34/102 (33%)
		Cadherin_repeat	253..347	CDD:206637	27/179 (15%)
		Cadherin_repeat	365..452	CDD:206637	26/111 (23%)
		Cadherin_repeat	461..555	CDD:206637	30/97 (31%)
PCDHB5	NP_056484.2	Cadherin_2	30..112	CDD:311943	18/96 (19%)
		Cadherin_repeat	140..238	CDD:206637	34/100 (34%)
		Cadherin_repeat	247..342	CDD:206637	17/97 (18%)
		Cadherin_repeat	356..446	CDD:206637	12/89 (13%)
		Cadherin_repeat	454..556	CDD:206637	27/113 (24%)
		Cadherin_repeat	575..663	CDD:206637	29/88 (33%)
		Cadherin_C_2	684..767	CDD:318652

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	131	1.000	Inparanoid score	I4632
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050