DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad96Cb and Pcdhb12

DIOPT Version :9

Sequence 1:	NP_001287524.1	Gene:	Cad96Cb / 43033	FlyBaseID:	FBgn0039294	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_775122.2	Gene:	Pcdhb12 / 25133	RGDID:	3266	Length:	797	Species:	Rattus norvegicus

Alignment Length:	781	Identity:	190/781 - (24%)
Similarity:	302/781 - (38%)	Gaps:	204/781 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 QWIYYAILSLCWFNKATLGAILDSRCYLEGGGSAESFLATEDLAVGSIIGKLRING--------- 61
            |..:..||||.|  |::..||..|.......|...:.||.:   :|..:|:|...|
  Rat    13 QVFFLTILSLLW--KSSSEAIRYSMPEETESGYMVANLAKD---LGIRVGELSSRGAQIHYKGNK 72

  Fly    62 ---DANAETGDINLSLREKNAPVEIHPGTKELALSVELDKE---GVRGPSSIYVNVICIRRHSTD 120
               ..:||||  ||.|:||                  ||:|   |...|..:...:|.     .:
  Rat    73 ELLQLDAETG--NLFLKEK------------------LDRELLCGETEPCVLNFQIIL-----EN 112

  Fly   121 PSFVIPVNVRVTDVNDNAPQWIGTPYTLTLSEVTVPGTRILQGARAEDADQPGPFSTVEYQVLPG 185
            |.......:::||:||::|::......||:.|...||| :.....|:|:| .|..:...|.|.|.
  Rat   113 PMQFFQTELQLTDINDHSPEFPNKKMLLTIPESAHPGT-VFPLKAAQDSD-IGSNAVQNYTVNPN 175

  Fly   186 PYSEYVQFLNPLEG----TLVLKKALDYEQLQNFTVKLRAQDQGTPPRHSDTLLRVVITDADDQN 246
            .:...|.. :..:|    .||:.:|||.|:....|:.|.|.|.|||.|...|.:.:.:.|.:|.:
  Rat   176 LHFHVVTH-SRTDGRKYPELVVDRALDREEQPELTLILTALDGGTPRRSGTTTVHIEVVDINDNS 239

  Fly   247 PKFQRESYSAEIPADGRPGELRMRPEPLKAVDQDEGICAPIQYTIVQ------------------ 293
            |:|.:..|..::| :..|  |......:.|.|.|.|:...:.|::.|
  Rat   240 PQFVQSLYKVQVP-ENNP--LNAFVVTVSATDLDAGVYGNVTYSLFQGYGVFQPFVIDEITGEIH 301

  Fly   294 -SQDAKYFRIHPHN--------GAIS-------------------------LLTPIGYAD----- 319
             |::..:..|..||        |.:|                         :|.|...|:
  Rat   302 LSKELDFEEISNHNIEIAATDGGGLSGKCTVAVQVLDVNDNAPELTIRKLTVLVPENSAETVVAV 366

  Fly   320 -----------------VANGATLVVKAT-----------QIDNPDR--YALT-----------T 343
                             :.|....::|.|           .:|..:|  |.:|           |
  Rat   367 FSVSDSDSGDNGRMVCSIPNNIPFLLKPTFENYYTLVTEGPLDRENRAEYNITITVSDLGTPRLT 431

  Fly   344 VQLTRPGSHSDL--STLAFVQKRFVMRIREDTAVGNRI--LALPTNKPGK--HLKYVIPDPVNSQ 402
            .|.|.....||:  :..||.|..:.|.:.|:.:....|  ::...:..|.  |:.|.:..|.:.|
  Rat   432 TQHTITVQVSDINDNAPAFTQTSYTMFVHENNSPALHIGTISATDSDSGSNAHITYSLLPPDDPQ 496

  Fly   403 FFSVGSL-------GELVLAKPLDYEKMTKHEFQVLATDGMTNSTAELTL---EVIDVNDWEPRF 457
             .::.||       |:|...:.||||.:...||.|.||||.:.:.:..||   .|:|.||..|..
  Rat   497 -LALDSLISINVDNGQLFALRALDYEALQSFEFYVGATDGGSPALSSQTLVRMVVLDDNDNAPFV 560

  Fly   458 RETHYEFMVPKSSLQSRADSFEGVLIGKVEAADGDRNDKLELS---LRGQHAGLFEIDSTGNIYM 519
            .........|.:.|..|| :..|.||.||.|.|.|......||   |:....|||.: ...|..:
  Rat   561 LYPLQNASAPCTELLPRA-AEPGYLITKVVAVDRDSGQNAWLSFQLLKATEPGLFSV-WAHNGEV 623

  Fly   520 RPEQLQSLNESTVH-LIAIATDTGVPPRSTSVPVSV-TMEG-----LTLARSGWNS-----NMLG 572
            |..:|.|..::..| |:.:..|.|.|.||.:|.:.| .::|     |.||....:|     ::|.
  Rat   624 RTTRLLSERDAQKHKLLLLVKDNGDPLRSANVTLHVLVVDGFSQPYLPLAEVAQDSMQDNYDVLT 688

  Fly   573 MF-----GMIMGLFLMIIVALSCYI-VRSKKQGKSASSGLGLGRNRV---HSQAH-SSVSSANLV 627
            ::     ..:..|||:.:|   .:: ||..::.:.||    ||...|   |..:| ..||||..:
  Rat   689 LYLVIALASVSSLFLLSVV---LFVGVRLCRRAREAS----LGDYSVPEGHFPSHLVDVSSAGTL 746

  Fly   628 T 628
            :
  Rat   747 S 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Cb	NP_001287524.1	Cadherin_repeat	46..137	CDD:206637	23/105 (22%)
		Cadherin_repeat	145..244	CDD:206637	31/102 (30%)
		Cadherin_repeat	253..347	CDD:206637	28/191 (15%)
		Cadherin_repeat	365..452	CDD:206637	27/100 (27%)
		Cadherin_repeat	461..555	CDD:206637	31/98 (32%)
Pcdhb12	NP_775122.2	Cadherin_2	30..112	CDD:400525	25/109 (23%)
		Cadherin_repeat	140..238	CDD:206637	31/100 (31%)
		Cadherin_repeat	247..342	CDD:206637	16/97 (16%)
		Cadherin_repeat	352..446	CDD:206637	15/93 (16%)
		Cadherin_repeat	454..556	CDD:206637	28/102 (27%)
		Cadherin_repeat	575..663	CDD:206637	29/89 (33%)
		Cadherin_C_2	687..769	CDD:406805	18/68 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	130	1.000	Inparanoid score	I4545
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050