DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Cb and CELSR2

DIOPT Version :9

Sequence 1:	NP_001287524.1	Gene:	Cad96Cb / 43033	FlyBaseID:	FBgn0039294	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001399.1	Gene:	CELSR2 / 1952	HGNCID:	3231	Length:	2923	Species:	Homo sapiens

Alignment Length:	683	Identity:	174/683 - (25%)
Similarity:	279/683 - (40%)	Gaps:	126/683 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 RVTDVNDNAPQWIGTPYTLTLSEVTVPGTRILQGARAEDADQPGPFSTVEYQVLPGPYSEYVQF- 193
            |..:|| .|||:....|..|:.|....||.: ...||.|.|: |....:||.:.....|...||
Human   171 RKRNVN-TAPQFQPPSYQATVPENQPAGTPV-ASLRAIDPDE-GEAGRLEYTMDALFDSRSNQFF 232

  Fly   194 -LNPLEGTLVLKKALDYEQLQNFTVKLRAQDQGTPPRHSDTLLRVVITDADDQNPKFQRESYSAE 257
             |:|:.|.:...:.||.|.......::.|||.|.|.|.:...|.:::||.:|.:|.|:::.|...
Human   233 SLDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKES 297

  Fly   258 IPADGRPGELRMRPEPL--KAVDQDEGICAPIQYTIVQ---SQDAKYFRIHPHNGAISLLTPIGY 317
            :..:     |.:..|.|  :|.|.|....|.|.|.:::   ...::.|.|.|.:|.|....|:..
Human   298 LREN-----LEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDR 357

  Fly   318 ADVANGATLVVKATQIDNPDRYALTTVQLTRPGSHSDLSTLAFVQKRFVMRIREDTAVGNRILAL 382
            .:|.:....|..:.|..:|...:.|..........:| :...|.:||:|:::|||...|..:|.:
Human   358 EEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDND-NAPQFSEKRYVVQVREDVTPGAPVLRV 421

  Fly   383 PTNKPGKHLKYVIPDPVNS-----QFFSVGSLGELVLAKPLDYEKMTKHEFQVLATDG----MTN 438
            ..:...|....|:...:.|     ||:.....|.|.:..|||||...::..:|.|.||    ::|
Human   422 TASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSN 486

  Fly   439 STAELTLEVIDVNDWEPRFRETHYEFMVPKSSLQSRADSFEGVLIGKVEAADGDRND--KLELSL 501
            .:..:|::|:|:||..|.|..|.::..|.:|...       |.|:..|:|.|.|..|  :||..|
Human   487 VSGLVTVQVLDINDNAPIFVSTPFQATVLESVPL-------GYLVLHVQAIDADAGDNARLEYRL 544

  Fly   502 RG-QHAGLFEIDS-TGNIYMRPEQLQSLNESTVHLIAI---ATDTGVPPRSTSVPVSVTMEGLTL 561
            .| .|...|.|:: ||.|.:..|    |:...|...:.   |.|.|.|..:.|..||||:..:
Human   545 AGVGHDFPFTINNGTGWISVAAE----LDREEVDFYSFGVEARDHGTPALTASASVSVTVLDV-- 603

  Fly   562 ARSGWNSNMLGMFGMIMGLFLMIIVALSCYIVRSKKQGKSASSGLGLGRNRVHSQAHSSVSSANL 626
                 |.|             ........|.||..:.....:|.:.:  :.|...|||      :
Human   604 -----NDN-------------NPTFTQPEYTVRLNEDAAVGTSVVTV--SAVDRDAHS------V 642

  Fly   627 VTHEKLAGNGNGNGASVTSGGVSVLHMKHGGNITMANPMNNGLHHVASGASSSMALGSSAALLER 691
            :|::..:|| ..|..|:||       ...||.:::|.|::..|..       ...|..:|:
Human   643 ITYQITSGN-TRNRFSITS-------QSGGGLVSLALPLDYKLER-------QYVLAVTAS---- 688

  Fly   692 ERERERDRERQRESYAATVRIFLPGIVSRASANGQLFEEDEIEHDSLQTENNNRKVAATGVASGG 756
                  |..||     .|.:|.:.  |:.|:.:..:|:      .|..|.|.|....|      |
Human   689 ------DGTRQ-----DTAQIVVN--VTDANTHRPVFQ------SSHYTVNVNEDRPA------G 728

  Fly   757 VTTISTTPANAGSNLLSATDAMGSSENNLTVYF 789
            .|.:          |:||||. .:.||....||
Human   729 TTVV----------LISATDE-DTGENARITYF 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Cb	NP_001287524.1	Cadherin_repeat	46..137	CDD:206637	3/6 (50%)
		Cadherin_repeat	145..244	CDD:206637	30/100 (30%)
		Cadherin_repeat	253..347	CDD:206637	21/98 (21%)
		Cadherin_repeat	365..452	CDD:206637	26/95 (27%)
		Cadherin_repeat	461..555	CDD:206637	29/100 (29%)
CELSR2	NP_001399.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..198		9/27 (33%)
		Cadherin_repeat	185..285	CDD:206637	30/101 (30%)
		Cadherin_repeat	293..395	CDD:206637	22/107 (21%)
		Cadherin_repeat	404..501	CDD:206637	27/96 (28%)
		Cadherin_repeat	509..606	CDD:206637	32/114 (28%)
		Cadherin_repeat	614..708	CDD:206637	29/133 (22%)
		Cadherin_repeat	716..811	CDD:206637	15/52 (29%)
		Cadherin_repeat	819..917	CDD:206637
		Cadherin_repeat	925..1019	CDD:206637
		Cadherin_repeat	1042..1120	CDD:206637
		EGF_CA	1289..1324	CDD:238011
		EGF_CA	1333..1366	CDD:238011
		LamG	1369..1552	CDD:238058
		EGF_CA	1578..1609	CDD:238011
		LamG	1618..1767	CDD:238058
		EGF_CA	1795..1829	CDD:238011
		EGF	1832..1865	CDD:278437
		EGF_Lam	1924..1969	CDD:214543
		HormR	1972..2034	CDD:214468
		GAIN	2052..2287	CDD:293098
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2213..2238
		GPS	2315..2368	CDD:197639
		7tm_4	2402..2605	CDD:304433
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2688..2838
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2854..2888
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910