DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad96Cb and Pcdha9

DIOPT Version :9

Sequence 1:	NP_001287524.1	Gene:	Cad96Cb / 43033	FlyBaseID:	FBgn0039294	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_619602.1	Gene:	Pcdha9 / 192161	MGIID:	2447322	Length:	979	Species:	Mus musculus

Alignment Length:	875	Identity:	196/875 - (22%)
Similarity:	320/875 - (36%)	Gaps:	209/875 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 INHQWIYYAILSLCWFNKATLGAILDSRCYLEGG---------------GSAE-SFLATEDLAVG 51
            ::.:|..:.:|      :....:::.|:|...|.               ||.: .:...|:...|
Mouse    14 VHLRWHIHGLL------RQENASVVISKCLRHGAWRLLLWLLLLATWDVGSGQLHYSVPEEAKHG 72

  Fly    52 SIIGKLRINGDANAETGDI-----NLSLREKNAPVEIHPGTKELALSVELDKE---GVRGPSSIY 108
            :.:|  ||..|...|..::     .:..:::...:|::.....|.::..:|:|   |.....||:
Mouse    73 TFVG--RIAQDLGLELAELVPRLFRVVSKDRGDLLEVNLQNGILFVNSRIDREELCGQNAECSIH 135

  Fly   109 VNVICIRRHSTDPSFVIPVNVRVTDVNDNAPQWIGTPYTLTLSEVTVPGTRI-LQGARAEDADQP 172
            :.||..|     |..|..|.|.|.|:|||.|.:......:.::|..:..:|. |:|  |.||| .
Mouse   136 LEVIVDR-----PLQVFHVEVEVRDINDNPPIFSVAEQKILVAESRLLDSRFPLEG--ASDAD-V 192

  Fly   173 GPFSTVEYQVLPGPYSEYVQFLNPLEG-----TLVLKKALDYEQLQNFTVKLRAQDQGTPPRHSD 232
            |..|.:.|::....:  ::..:....|     .|||:|.:|.|:.....:.|.|.|.|.|.....
Mouse   193 GENSMLTYKLSSNEF--FILDIVNKRGKGKFPVLVLRKLIDREENPQLKLLLTATDGGKPEFTGS 255

  Fly   233 TLLRVVITDADDQNPKFQRESYSAEIPADGRPGELRMRPEP--------LKAVDQDEGICAPIQY 289
            ..|.:.:.|.:|..|.|.|..|           |::|....        |.|.|.||||...::|
Mouse   256 VSLLIQVLDVNDNAPVFDRSVY-----------EVKMYENQENKTLVIWLNATDSDEGINKEVEY 309

  Fly   290 ---TIVQSQDAKYFRIHPHNGAISL-----------------LTPIGYAD-VANGATLVVKATQI 333
               ::..|...:.|.|:...|.|.:                 .|..||.. ||:...||....:.
Mouse   310 SFSSLASSIIRQKFLINEKTGEIKINGAIDFEESNNYEIHVDATDKGYPPMVAHCTVLVEILDEN 374

  Fly   334 DNPDRYALTTVQLTRPGSHSDLSTLAFVQKRFVMRIREDTAVGNRILALPTNKPGKHLKYVIPDP 398
            ||.....||::.|.........|.:|.:...     .:|:.|..::....||    |:.:.:...
Mouse   375 DNAPEIVLTSLSLPVKEDAPLGSVIALISVS-----DKDSGVNGQVTCSLTN----HVPFKLVST 430

  Fly   399 VNSQFFSVGSLGELVLAKPLDYEKMTKHEFQVLATDGMTNS---TAELTLEVIDVNDWEPRFRET 460
            ..:.:       .|||...||.|....::..|.|.||.:.|   ||.:::||.||||..|.|...
Mouse   431 FKNYY-------SLVLDSALDRETTADYKVVVTARDGGSPSLWATASVSVEVADVNDNAPAFAHP 488

  Fly   461 HYEFMVPKSS---------LQSRADSFEGVLI--GKVEAADGDRNDKLELSLRGQHAGLFEIDST 514
            .|...|.:::         |...||:.|..|:  ..||...|:|   |..|....||      .:
Mouse   489 EYTVFVKENNPPGVHIFTVLAVDADAQENALVSYSLVERRVGER---LLSSYVSVHA------ES 544

  Fly   515 GNIYMRPEQLQSLNESTVHLIAI---ATDTGVPPRSTSVPVSVTMEGLTLARSGWNSNMLGMFGM 576
            |.::    .||.|:...:.|:..   |.|.|||...::|.:.|.::       ..|.|...:.|.
Mouse   545 GKVF----ALQPLDHEELELLQFQVSARDAGVPALGSNVTLQVFVQ-------DENDNPPTLLGH 598

  Fly   577 IMGLFLMIIVALSCYIVRSKKQGKSASSGLGLGRNRVHSQAHS-SVSSANLVTHEKLAGNGNGNG 640
            ..|                             |.....||..| ||.:.::|:..:.....:|..
Mouse   599 QSG-----------------------------GPAGEFSQLVSRSVGAGHVVSKVRAVDADSGYN 634

  Fly   641 ASVTSGGVSVLHMKHGGNITMANPMNNGLHHVASGASSSMALGSSAALLERERERER------DR 699
            |.::    ..||...|..    :|...||:        :..:..:.||.|.:..|:|      |.
Mouse   635 AWLS----YELHPTVGAR----SPFRVGLY--------TGEISMTRALDESDLPRQRLLVLVKDH 683

  Fly   700 ERQRESYAATVRIFL--PGIVSRASANGQLFEEDEIEHDSLQTENNNRKVAATGVASGGVTTI-- 760
            ........|||.:.|  .|.|.:||:.|  .........||...|....:|...|:|..|.|:
Mouse   684 GEPMLIATATVLVSLVENGQVPKASSQG--LPNSSRREASLMDVNVYLIIAICAVSSLLVLTLLL 746

  Fly   761 ------STTPANAGSNL----LSATDAMGS 780
                  |..|..||..|    |..:.|:|:
Mouse   747 YTALRCSAVPMQAGCGLGKPTLVCSSAVGT 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Cb	NP_001287524.1	Cadherin_repeat	46..137	CDD:206637	24/98 (24%)
		Cadherin_repeat	145..244	CDD:206637	25/104 (24%)
		Cadherin_repeat	253..347	CDD:206637	27/122 (22%)
		Cadherin_repeat	365..452	CDD:206637	22/89 (25%)
		Cadherin_repeat	461..555	CDD:206637	26/107 (24%)
Pcdha9	NP_619602.1	Cadherin_2	60..141	CDD:285466	16/82 (20%)
		Cadherin_repeat	167..268	CDD:206637	25/105 (24%)
		Cadherin_repeat	276..376	CDD:206637	23/110 (21%)
		Cadherin_repeat	384..481	CDD:206637	26/112 (23%)
		Cadherin_repeat	489..591	CDD:206637	28/121 (23%)
		Cadherin_repeat	611..699	CDD:206637	21/103 (20%)
		5 X 4 AA repeats of P-X-X-P	763..923		4/14 (29%)
		Cadherin_tail	828..971	CDD:292596
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	859..979
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	136	1.000	Inparanoid score	I4532
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050