DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Cb and Cdhr1

DIOPT Version :9

Sequence 1:	NP_001287524.1	Gene:	Cad96Cb / 43033	FlyBaseID:	FBgn0039294	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_570948.1	Gene:	Cdhr1 / 170677	MGIID:	2157782	Length:	859	Species:	Mus musculus

Alignment Length:	627	Identity:	153/627 - (24%)
Similarity:	270/627 - (43%)	Gaps:	111/627 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 EDLAVGSIIGKLRINGDANAETGDINLSLREKNA---PVEIHPGTKELALSVELDKEGVRGPSSI 107
            |::..||.|.|::.........|.:..||:..::   .::.|.|...|.....||.|..|   :.
Mouse   146 ENIPAGSSIFKVQAEDKDTGSGGSVTYSLQNLHSSKFSMDRHSGVLRLQAGATLDYEKSR---AH 207

  Fly   108 YVNVICI----RRHSTDPSF--VIPVNVRVTDVNDNAPQWIGTPYTLTLSEVTVPGTRILQGARA 166
            |:.||..    |....|..|  ...|.:.|.||.|.||.::||||...:.|.|:||:.:|. ..|
Mouse   208 YITVIAKDGGGRLRGADMVFSATTTVTINVEDVQDTAPIFVGTPYYGYVYEDTLPGSEVLT-VVA 271

  Fly   167 EDADQPGPFSTVEYQVLPGPYSEYVQFLNPLEGTL-VLKK-ALDYEQLQNFTVKL-RAQDQGTPP 228
            .|.|:..| :.:.|::|  ..|:.:..:|...|.: ||:. ||...::....|:: .....|:|.
Mouse   272 IDGDRGKP-NHILYRLL--NESDGIFEINETSGAISVLQSPALLRREVYELHVQVTEVNSPGSPA 333

  Fly   229 RHSDTLLRVVITDADDQNPKFQRES---YSAEIPADGRP--GELRMRPEPLKAVDQDEGICAPIQ 288
            ..:...:.:.|.|.::..|.|..||   ...|:.....|  ||: :|...:...|.|:|..|...
Mouse   334 AQATVPVTIRIVDLNNHPPTFYGESGPQNKFELSMFEHPPQGEI-LRGLKITVNDSDQGANAKFN 397

  Fly   289 YTIVQSQDAKYFRIHP----HNGAISLLTPIGYADVANGA----------TLVVKATQIDNPDRY 339
            ..:|  .....||:.|    :...::::       |.|.|          |..:.|.:::.|:::
Mouse   398 LRLV--GPGGIFRVVPQTVLNEAQVTII-------VENSAAIDFEKSKLLTFKLLAIEVNTPEKF 453

  Fly   340 ALT---TVQLTRPGSHSDLSTLAFVQKRFVMRIREDTAVGNRILAL----PTNKPGKHLKYVIPD 397
            :.|   .:||.    .::.:...|....::.||.|:...|:.::|:    |...|...:.|.|..
Mouse   454 SSTADIVIQLL----DTNDNVPKFTSHYYIARIPENAPGGSNVVAVTAVDPDTGPWGKVHYSIYG 514

  Fly   398 PVNSQFFSVGSLGELVLAKP---LDYEKMTKHEFQVLATDGMTN--STAELTLEVIDVNDWEPRF 457
            ..:..|....|.| |:..:|   ||.|..:::.|.|.|.| |..  |.||:.:.::||||..|:|
Mouse   515 TGSDLFLIHPSTG-LIYTQPWASLDAEGTSRYNFYVKAED-MDGRYSLAEVFVTLLDVNDHYPQF 577

  Fly   458 RETHYEFMVPKSSLQSRADSFEGVLIG---KVEAADGDR---NDKLELSL-RGQHAGLFEIDS-T 514
            .:          |:|.:.     :::|   |:||.|.|.   |:.::.|: |.:...:|:||: |
Mouse   578 VQ----------SVQEKT-----MVLGTPLKIEATDQDAEEPNNLVDYSITRAEPVNVFDIDAHT 627

  Fly   515 GNIYMRP--EQLQSLNESTV------HLIAIATDTGVPPRSTSVPVSVTM-EGLTLARSGW---- 566
            |.|.::.  ..|::|:..|.      .|...|.|.|.|..||:..:.:.: :...|:|...
Mouse   628 GEIRLKNSIRSLEALHNITPSGDYSWSLQVQAKDRGSPSFSTTALLKIDITDTERLSRGSMAAFL 692

  Fly   567 ---NSNMLGMFGMIMGLFLMIIVALSCYIV-----RSKKQGK 600
               ..|.:...|::.|: :.|:||::..|.     |:||..|
Mouse   693 IQTKDNPMKAVGVLAGV-MAIVVAITVLISTATFWRNKKSNK 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Cb	NP_001287524.1	Cadherin_repeat	46..137	CDD:206637	25/99 (25%)
		Cadherin_repeat	145..244	CDD:206637	25/101 (25%)
		Cadherin_repeat	253..347	CDD:206637	22/115 (19%)
		Cadherin_repeat	365..452	CDD:206637	27/95 (28%)
		Cadherin_repeat	461..555	CDD:206637	27/109 (25%)
Cdhr1	NP_570948.1	Cadherin_repeat	42..130	CDD:206637
		Cadherin_repeat	139..242	CDD:206637	25/98 (26%)
		Cadherin_repeat	251..350	CDD:206637	25/102 (25%)
		Cadherin_repeat	364..469	CDD:206637	22/118 (19%)
		Cadherin_repeat	478..573	CDD:206637	28/96 (29%)
		Cadherin_repeat	580..679	CDD:206637	27/103 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	793..838
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24028
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100