DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Cb and Pcdha5

DIOPT Version :9

Sequence 1:	NP_001287524.1	Gene:	Cad96Cb / 43033	FlyBaseID:	FBgn0039294	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_034089.1	Gene:	Pcdha5 / 12941	MGIID:	1298371	Length:	934	Species:	Mus musculus

Alignment Length:	622	Identity:	160/622 - (25%)
Similarity:	260/622 - (41%)	Gaps:	97/622 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 EGGGSAESFLATEDLAVGSIIGKLRINGDANAETGDI-----NLSLREKNAPVEIHPGTKELALS 93
            |.|.....:...|:...|:.:|  ||..|...|..::     .::.:::...:|::.....|.::
Mouse    25 EAGSGQLHYSIPEEAKHGTFVG--RIAQDLGLELTELVPRLFRVASKDRGDLLEVNLQNGILFVN 87

  Fly    94 VELDKEGVRGPS---SIYVNVICIRRHSTDPSFVIPVNVRVTDVNDNAPQWIGTPYTLTLSEVTV 155
            ..:|:|.:.|.|   ||::.||..|     |..|..|.|.|.|:|||.|::......|.:.|..:
Mouse    88 SRIDREELCGRSAECSIHLEVIVDR-----PLQVFHVEVEVKDINDNPPKFSRPEQRLFILESRM 147

  Fly   156 PGTRI-LQGARAEDADQPGPFSTVEYQVLPGPYSEYVQFLNPLEGT---LVLKKALDYEQLQNFT 216
            |.:|. ::||...|.   |..:.:.|::.|..|.:.....|..|.:   |||||.||.|:.|...
Mouse   148 PDSRFPVEGASDLDI---GANAALSYKINPNEYFDLDVKRNEEETSVLQLVLKKPLDREETQEHR 209

  Fly   217 VKLRAQDQGTPPRHSDTLLRVVITDADDQNPKFQRESYSAEIPADGRPGELRMRPEPLKAVDQDE 281
            :.|.|.|.|.|.......|.:.:.||:|..|:|.:..|:..:..:...|.|.::   |.|.|.||
Mouse   210 LLLIAIDGGKPELTGTVQLLIDVLDANDNAPEFDKSIYNVRLLENTPNGTLVIK---LNASDADE 271

  Fly   282 GICAPIQY---TIVQSQDAKYFRIHPHNGAISLLTPIGYAD-----------------VANGATL 326
            ||...|.|   .:|.......|.|...:|.|.:...:.|.|                 :|....:
Mouse   272 GINKEILYFFSNLVLDDVKSKFTIDSSSGEIKVKGELDYEDCKVYEINIDAVDRSAFPLAGHCKI 336

  Fly   327 VVKATQI-DNPDRYALTTVQLTRPGSHSDLSTLAFVQKRFVMRIREDTAVGNRILALPTNKPGKH 390
            :||...: ||....|:|::.|    ...:.:.||.|.....:..|:..|.|....:|..:
Mouse   337 IVKLVDVNDNVPEMAITSIFL----PIKEDAPLATVIALISVSDRDSGANGQVTCSLTPH----- 392

  Fly   391 LKYVIPDPVNSQFFSVGSLGELVLAKPLDYEKMTKHEFQVLATDGMTNS---TAELTLEVIDVND 452
                ||..:.|.|.:..|   |||.:.||.|.:..::..|.|.||.:.|   ||.:::||.||||
Mouse   393 ----IPFKLVSTFKNYYS---LVLDRALDRETIANYDVVVTARDGGSPSLWATASVSVEVADVND 450

  Fly   453 WEPRFRETHYEFMVPKSSLQSR---------ADSFEGVLI--GKVEAADGDRNDKLELSLRGQHA 506
            ..|.|.:..|...|.:::....         ||:.|..|:  ..||...|:|   |..|....||
Mouse   451 NVPAFAQPEYTVFVKENNPPGAHIFTVSAMDADAQENALVSYSLVERRVGER---LLSSYVSVHA 512

  Fly   507 GLFEIDSTGNIYMRPEQLQSLNESTVHLIAI---ATDTGVPPRSTSVPVSVTMEGLTLARSGWNS 568
                  .:|.::    .||.|:...:.|:..   |.|.|||    ::..:||::...|..:....
Mouse   513 ------ESGKVF----ALQPLDHEELELLQFQVSARDAGVP----ALGSNVTLQVFVLDENDNAP 563

  Fly   569 NMLGMFGMIMGLFLMIIVALSCYIVRSKKQGKSASSG 605
            .:||..|. .|...::..::|...|.:|.:...|.||
Mouse   564 TLLGPQGS-GGTIELLSRSVSSGHVVAKVRAVDADSG 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Cb	NP_001287524.1	Cadherin_repeat	46..137	CDD:206637	25/98 (26%)
		Cadherin_repeat	145..244	CDD:206637	30/102 (29%)
		Cadherin_repeat	253..347	CDD:206637	26/114 (23%)
		Cadherin_repeat	365..452	CDD:206637	26/89 (29%)
		Cadherin_repeat	461..555	CDD:206637	24/107 (22%)
Pcdha5	NP_034089.1	Cadherin_2	30..111	CDD:285466	17/82 (21%)
		Cadherin_repeat	137..238	CDD:206637	30/103 (29%)
		Cadherin_repeat	246..346	CDD:206637	22/102 (22%)
		Cadherin_repeat	354..451	CDD:206637	31/112 (28%)
		Cadherin_repeat	459..561	CDD:206637	27/118 (23%)
		Cadherin_repeat	578..667	CDD:206637	6/22 (27%)
		Cadherin_tail	783..926	CDD:292596
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	136	1.000	Inparanoid score	I4532
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050