DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Cb and Pcdha4

DIOPT Version :9

Sequence 1:	NP_001287524.1	Gene:	Cad96Cb / 43033	FlyBaseID:	FBgn0039294	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_031792.1	Gene:	Pcdha4 / 12936	MGIID:	1298406	Length:	947	Species:	Mus musculus

Alignment Length:	577	Identity:	157/577 - (27%)
Similarity:	244/577 - (42%)	Gaps:	104/577 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 EGGGSAESFLATEDLAVGSIIGKLRINGDANAETGDI-----NLSLREKNAPVEIHPGTKELALS 93
            |.|.|...:...|:...|:.:|  ||..|...|..::     .::.:::...:|::.....|.::
Mouse    25 EAGNSQIHYSIPEEAKHGTFVG--RIAQDLGLELTELVPRLFRVASKDRGDLLEVNLQNGILFVN 87

  Fly    94 VELDKEGVRGPS---SIYVNVICIRRHSTDPSFVIPVNVRVTDVNDNAPQWIGTPYTLTLSEVTV 155
            ..:|:|.:.|.|   ||::.||..|     |..|..|.|.|.|:|||.|::..|...|.::|...
Mouse    88 SRIDREELCGRSAECSIHLEVIVDR-----PLQVFHVEVEVRDINDNPPRFPTTQKNLFIAESRP 147

  Fly   156 PGTRI-LQGARAEDADQPGPFSTVEYQVLPGPY--------SEYVQFLNPLEGTLVLKKALDYEQ 211
            ..|.. |:|  |.||| .|..:.:.|::.|..|        .|.|:.|.     |||:|:||.|:
Mouse   148 LDTWFPLEG--ASDAD-IGINAVLTYRLSPNDYFSLEKPSNDERVKGLG-----LVLRKSLDREE 204

  Fly   212 LQNFTVKLRAQDQGTPPRHSDTLLRVVITDADDQNPKFQRESYSAEIPADGRPGELRMRPEPLKA 276
            .....:.|...|.|.|.......|.:.:.||:|..|.|.|..|:.::|.:...|.|.::   :.|
Mouse   205 TPEIILVLTVTDGGKPELTGSVQLLITVLDANDNAPVFDRSLYTVKLPENVPNGTLVVK---VNA 266

  Fly   277 VDQDEGICAPIQYTIVQ--SQDAKY-FRIHPHNGAISLLTPIGYADVANGATLVVKATQIDNPDR 338
            .|.|||:...|.|:...  |.:.|| |.|.|.:|.|.:.   ||.|.....:..:....||..
Mouse   267 SDLDEGVNGDIMYSFSTDISPNVKYKFHIDPVSGEIIVK---GYIDFEECKSYEILIEGIDKG-- 326

  Fly   339 YALTTVQLTRPGS----------HSDLSTLAFVQKRFVMRIREDTAVGNRILAL------PTNKP 387
                  ||...|.          :.::..|.|  |...:.|||::.||. ::||      .|...
Mouse   327 ------QLPLSGHCKVIVQVEDINDNVPELEF--KSLSLPIRENSPVGT-VIALISVSDRDTGVN 382

  Fly   388 GK---HLKYVIPDPVNSQFFSVGSLGELVLAKPLDYEKMTKHEFQVLATDGMTNS---TAELTLE 446
            |:   .|...:|..:.|.|.:..|   |||...||.|....::..|.|.||.:.|   ||.:::|
Mouse   383 GQVTCSLTSHVPFKLVSTFKNYYS---LVLDSALDRETTADYKVVVTARDGGSPSLWATASVSVE 444

  Fly   447 VIDVNDWEPRFRETHYEFMVPKSSLQSR---------ADSFEGVLI--GKVEAADGDRNDKLELS 500
            |.||||..|.|.:..|...|.:::....         ||:.|..|:  ..||...|:|   |..|
Mouse   445 VADVNDNAPVFAQPEYTVFVKENNPPGAHIFTVSAMDADAQENALVSYSLVERRVGER---LLSS 506

  Fly   501 LRGQHAGLFEIDSTGNIYMRPEQLQSLNESTVHLIAI---ATDTGVPPRSTSVPVSV 554
            ....||      .:|.::    .||.|:...:.|:..   |.|.|||...::|.:.|
Mouse   507 YVSVHA------ESGKVF----ALQPLDHEELELLRFQVSARDAGVPALGSNVTLQV 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Cb	NP_001287524.1	Cadherin_repeat	46..137	CDD:206637	25/98 (26%)
		Cadherin_repeat	145..244	CDD:206637	30/107 (28%)
		Cadherin_repeat	253..347	CDD:206637	25/96 (26%)
		Cadherin_repeat	365..452	CDD:206637	31/98 (32%)
		Cadherin_repeat	461..555	CDD:206637	26/108 (24%)
Pcdha4	NP_031792.1	Cadherin_2	30..111	CDD:285466	17/82 (21%)
		Cadherin_repeat	139..238	CDD:206637	30/106 (28%)
		Cadherin_repeat	247..346	CDD:206637	27/112 (24%)
		Cadherin_repeat	354..451	CDD:206637	32/100 (32%)
		Cadherin_repeat	459..561	CDD:206637	26/108 (24%)
		Cadherin_repeat	581..670	CDD:206637
		6 X 4 AA repeats of P-X-X-P	734..891
		Required for interaction with FYN. /evidence=ECO:0000269\|PubMed:9655502	738..947
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	761..805
		Cadherin_tail	796..939	CDD:292596
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	824..853
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	891..947
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	136	1.000	Inparanoid score	I4532
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050