DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Cb and Pcdha1

DIOPT Version :9

Sequence 1:	NP_001287524.1	Gene:	Cad96Cb / 43033	FlyBaseID:	FBgn0039294	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_473413.1	Gene:	Pcdha1 / 116731	MGIID:	2150982	Length:	948	Species:	Mus musculus

Alignment Length:	736	Identity:	177/736 - (24%)
Similarity:	297/736 - (40%)	Gaps:	147/736 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 EGGGSAESFLATEDLAVGSIIGKLRINGDANAETGDI-----NLSLREKNAPVEIHPGTKELALS 93
            |.|.....:...|:...|:.:|  ||..|...|..::     .::.:::...:|::.....|.::
Mouse    26 EAGSGQIHYSVPEEAKHGTFVG--RIAQDLGLELTELVPRLFRVASKDRGDLLEVNLQNGILFVN 88

  Fly    94 VELDKEGVRGPS---SIYVNVICIRRHSTDPSFVIPVNVRVTDVNDNAPQWIGTPYTLTLSEVTV 155
            ..:|:|.:.|.|   ||::.||..|     |..|..|.|:|.|:|||.|.:.|....:.:.|...
Mouse    89 SRIDREELCGRSAECSIHLEVIVDR-----PLQVFHVEVKVKDINDNPPVFKGAEQRIFIPENRQ 148

  Fly   156 PGTRI-LQGARAEDADQPGPFSTVEYQVLPGPY-SEYVQFLNPLEG--TLVLKKALDYEQLQNFT 216
            ..:|. |:|  |.||| .|..|.:.|.:.|..| |..|:..:.|..  :|.|:|:||.|:.....
Mouse   149 LDSRFPLEG--AVDAD-IGANSLLTYTLSPTDYFSLKVETTDELSKSLSLELRKSLDREETPELQ 210

  Fly   217 VKLRAQDQGTPPRHSDTLLRVVITDADDQNPKFQRESYSAEIPADGRPGELRMRPEPLKAVDQDE 281
            :.|.|.|.|.|.......|::.:.|.:|..|.|.:..|.|::......|.|   ...|.|.|.||
Mouse   211 LLLTATDGGKPELEGTVRLQITVLDVNDNAPLFDQAIYRAQLVESTVNGTL---VTTLNATDADE 272

  Fly   282 GICAPIQYTI---VQSQDAKYFRIHPHNGAISLLTPIGY-----------------ADVANGATL 326
            |:...:.::.   |.....:.|.:...:|.|.::..:.|                 ..::|...:
Mouse   273 GVNGEVVFSFGNDVSLDIQEKFNVDSLSGEIRVIGDLDYEKTKSYEIQIKAVDKGTPSMSNHCKV 337

  Fly   327 VVKATQI-DNPDRYALTTVQLTRPGSHSDLSTLAFVQKRFVMRIREDTAVGNRILAL------PT 384
            :||...| ||....::|::.|.                     |:|||.: |.|:||      .:
Mouse   338 LVKVLDINDNAPELSITSLSLP---------------------IKEDTPL-NTIIALIKVSDIDS 380

  Fly   385 NKPGK---HLKYVIPDPVNSQFFSVGSLGELVLAKPLDYEKMTKHEFQVLATDGMTNS---TAEL 443
            ...|:   .|...:|..:.|.|.:..|   |||...||.|....::..|.|.||.:.|   ||.:
Mouse   381 GVNGQVTCSLTPHVPFKLVSTFKNYYS---LVLDSTLDRETTADYKVVVTARDGGSPSLWATASV 442

  Fly   444 TLEVIDVNDWEPRFRETHYEFMVPKSSLQSR---------ADSFEGVLI--GKVEAADGDRNDKL 497
            ::||.||||..|.|.:..|...|.:::....         ||:.|..|:  ..||...|:|   |
Mouse   443 SVEVADVNDNAPVFAQPEYTVFVKENNPPGAHIFTVSAMDADAQENALVSYSLVERRVGER---L 504

  Fly   498 ELSLRGQHAGLFEIDSTGNIYMRPEQLQSLNESTVHLIAI---ATDTGVPPRSTSVPVSVTMEGL 559
            ..|....||      .:|.::    .||.|:...:.|:..   |.|.|||    ::..:||::..
Mouse   505 LSSYVSVHA------ESGKVF----ALQPLDHEELELLQFQVSARDAGVP----ALGSNVTLQVF 555

  Fly   560 TLARSGWNSNMLGMFGMIMGLFLMIIVA--LSCYIVRSKKQGKSASSG------------LGLGR 610
            .|..   |.|...:.|...|..:..:|:  :....|.:|.:...|.||            .|..|
Mouse   556 VLDE---NDNPPTLLGPHAGSAVSELVSRTMGAGHVVTKVRAVDADSGYNAWLSYELQPPTGGAR 617

  Fly   611 N--RVHSQAHSSVSSANL----VTHEKLAGNGNGNGASVTSGGVSVLHMKHGGNITMANPMNNGL 669
            |  ||........::.:|    |..::|......:|..:.:...:||     .::..::|:....
Mouse   618 NPFRVGLYTGEISTTRSLDEVDVPRQRLLVLVKDHGEPMLTATATVL-----VSLVESSPIQKAS 677

  Fly   670 HHVASGASSSMALGSSAALLE 690
            ..|.:|     |:||.|:|::
Mouse   678 LPVLTG-----AVGSKASLVD 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Cb	NP_001287524.1	Cadherin_repeat	46..137	CDD:206637	25/98 (26%)
		Cadherin_repeat	145..244	CDD:206637	29/102 (28%)
		Cadherin_repeat	253..347	CDD:206637	22/114 (19%)
		Cadherin_repeat	365..452	CDD:206637	31/98 (32%)
		Cadherin_repeat	461..555	CDD:206637	24/107 (22%)
Pcdha1	NP_473413.1	Cadherin_2	31..112	CDD:285466	17/82 (21%)
		Cadherin_repeat	138..239	CDD:206637	29/103 (28%)
		Cadherin_repeat	247..347	CDD:206637	19/102 (19%)
		Cadherin_repeat	355..452	CDD:206637	33/121 (27%)
		Cadherin_repeat	460..562	CDD:206637	28/121 (23%)
		Cadherin_repeat	579..668	CDD:206637	17/93 (18%)
		Cadherin_tail	797..940	CDD:292596
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	136	1.000	Inparanoid score	I4532
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050