DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Cb and Pcdhb6l

DIOPT Version :9

Sequence 1:	NP_001287524.1	Gene:	Cad96Cb / 43033	FlyBaseID:	FBgn0039294	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	XP_017456586.1	Gene:	Pcdhb6l / 108348233	RGDID:	11376545	Length:	796	Species:	Rattus norvegicus

Alignment Length:	717	Identity:	175/717 - (24%)
Similarity:	276/717 - (38%)	Gaps:	166/717 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 EGGGSAESFLATEDLAVGSIIGKLRINGDANAETGDINLSLREKNAP-------VEIHPGTKELA 91
            |.|..:..:...|:...|:.:..|  ..|.....|:  |:.||....       :::.|.|::|.
  Rat    24 EVGSESIQYAMLEETGRGTFVANL--TKDLGLRVGE--LAAREARVVFKGNRQYLQLDPQTQDLV 84

  Fly    92 LSVELDKEGVRGPSSIYVNVICIRRHSTDPSFVIPVNVRVTDVNDNAPQWIGTPYTLTLSEVTVP 156
            |:..||:|.:.|  |....|:..|....:|.......:||.|:||:||::......|.:||:|.|
  Rat    85 LNENLDREELCG--STEPCVLSFRVLLKNPLQFYQAELRVIDINDHAPEFPAKEMLLKISEITPP 147

  Fly   157 GTRILQGARAEDADQPGPFSTVEYQVLPGPYSEYVQFLNPLEG----TLVLKKALDYEQLQNFTV 217
            | :|.....|:|.| .|..|...|.|...|:. :|...|..:|    .|||.||||.|:.....:
  Rat   148 G-KIFPLKMAQDLD-VGSHSIQSYTVNDNPHF-HVLTRNRSDGRKFPELVLNKALDREEQDQLRL 209

  Fly   218 KLRAQDQGTPPRHSDTLLRVVITDADDQNPKFQRESYSAEIPADGRPGELRMRPEPLKAVDQDEG 282
            ||.|.|.|:|||...|.:::::.|.:|..|:|.:|.|..::|.:...|.|.:   .:.|.|.|.|
  Rat   210 KLTAVDGGSPPRFGTTEIQILVLDINDNAPEFAQELYEVQVPENNPVGSLLI---TVSARDLDTG 271

  Fly   283 ICAPIQYTIVQSQD---AKYFRIHPHNGAISLLT-------PIGYADV----ANGAT----LVVK 329
            ....:.|.:  |||   .:.|.|:...|.:.|.:       |..:.||    ..|.|    |||:
  Rat   272 SFGEVSYGL--SQDDGLNEPFEINTKTGEVRLKSMLDFEAFPFYHVDVEALDGGGLTGKCSLVVQ 334

  Fly   330 ATQI-DNPDRYALTTVQ--------------------------------------LTRPGSH--- 352
            ...: ||.....|:::.                                      |.||...
  Rat   335 VLDMNDNAPEVILSSLNSPIPENLPGIIVAVFSVSDADSGSNQQVMCSIDDNLPFLLRPSMENFY 399

  Fly   353 ----------------------------------------SDLSTLA--FVQKRFVMRIREDTA- 374
                                                    ||::..|  |.|..:.:.:.|:.:
  Rat   400 TLETDGALDRESRAEYNITITVTDMGTPRLTTQHTITVQVSDINDNAPTFTQTSYTLFVHENNSP 464

  Fly   375 ---VGNRILALPTNKPGKHLKYVIPDPVNSQFFSVGSL-------GELVLAKPLDYEKMTKHEFQ 429
               :|........:....|:.|.:. |.|....::.||       |:|...:.||||.:...|||
  Rat   465 ALHIGTISATDSDSGTNAHITYSLL-PRNDPHLALSSLVSINADNGQLFALRALDYESLKAFEFQ 528

  Fly   430 VLATD---GMTNSTAELTLEVIDVNDWEPRFRETHYEFMVPKSSLQSRADSFEGVLIGKVEAADG 491
            |.|||   ...:|.|.:.:.|:|.||..|..........||.:.|..|. :..|.|:.||.|.|.
  Rat   529 VNATDQGSPALHSQALVRVVVLDDNDNAPFVLYPLQNASVPCTELLPRV-AEPGYLVTKVVAVDR 592

  Fly   492 DRNDKLELS---LRGQHAGLFEIDSTGNIYMRPEQLQSLNESTVH-LIAIATDTGVPPRSTSVPV 552
            |......||   |:....|||.: ...|..:|..:|.|..:.:.| |:.:..|.|.||||.|..:
  Rat   593 DSGQNAWLSFQLLKATEPGLFSV-WAHNGEVRTTRLLSERDVSKHRLLLLVKDNGNPPRSASTTL 656

  Fly   553 SVTM-EG-----LTLARSGWNSN----------MLGMFGMIMGLFLMIIVALSCYIVRSKKQGKS 601
            .|.: :|     |.|.....:|.          ::.....:..|||..:|..  .:||..::.::
  Rat   657 HVLLVDGFSQPYLPLPEVAQDSTKDVEDTLTLYLVIALASVSSLFLFSVVLF--VVVRLCRRVRA 719

  Fly   602 AS 603
            ||
  Rat   720 AS 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Cb	NP_001287524.1	Cadherin_repeat	46..137	CDD:206637	24/97 (25%)
		Cadherin_repeat	145..244	CDD:206637	36/102 (35%)
		Cadherin_repeat	253..347	CDD:206637	27/150 (18%)
		Cadherin_repeat	365..452	CDD:206637	25/100 (25%)
		Cadherin_repeat	461..555	CDD:206637	30/97 (31%)
Pcdhb6l	XP_017456586.1	Cadherin_2	30..111	CDD:285466	19/86 (22%)
		Cadherin_repeat	139..237	CDD:206637	36/100 (36%)
		Cadherin_repeat	246..341	CDD:206637	24/99 (24%)
		Cadherin_repeat	354..445	CDD:206637	5/90 (6%)
		Cadherin_repeat	453..555	CDD:206637	26/102 (25%)
		Cadherin_repeat	578..662	CDD:206637	27/84 (32%)
		Cadherin_C_2	686..765	CDD:293101	8/38 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	130	1.000	Inparanoid score	I4545
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.050