DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Cb and LOC105946889

DIOPT Version :9

Sequence 1:	NP_001287524.1	Gene:	Cad96Cb / 43033	FlyBaseID:	FBgn0039294	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	XP_012815606.2	Gene:	LOC105946889 / 105946889	-ID:	-	Length:	807	Species:	Xenopus tropicalis

Alignment Length:	663	Identity:	147/663 - (22%)
Similarity:	251/663 - (37%)	Gaps:	137/663 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 HQWI-YYAILSLCWFNKATLGAILDSR------CYLEGGGSAESFLATEDLAVGSIIGKLRINGD 62
            ||.| .|..:::|:..|......:...      |.|.       ::.:|:...|:.:|  ||..|
Frog     9 HQSIEMYLQINVCFLEKRLFIVFMLQMAADLVLCQLH-------YMISEESKHGTFVG--RIAQD 64

  Fly    63 ANAETGDINLSLREKNAPVEIHPGTKELALSVE---------LDKEGVRGPSSIYVNVICIRRHS 118
            ...:..|||    .:...:....|:....::::         :|::.:  ...|.|.::.:....
Frog    65 LGLQISDIN----SRGLQIVSQDGSDYFQVNLQNGILFVNNIIDRDQL--CPKINVCIVHLEVII 123

  Fly   119 TDPSFVIPVNVRVTDVNDNAPQWIGTPYTLTLSEVTVPGTRI-LQGARAEDADQPGPFSTVEYQV 182
            ..|..:..|:|.:.|:|||.|.:....|.|.:|||.:||:|. |:|  |.||| .|..|...|.:
Frog   124 NKPVQIHHVDVEIEDINDNWPVFPSKDYKLIISEVRLPGSRFSLEG--AVDAD-VGTNSVTSYDI 185

  Fly   183 LPGPY-----SEYVQFLNPLEGTLVLKKALDYEQLQNFTVKLRAQDQGTPPRHSDTLLRVVITDA 242
            ....|     ..|......::  |||||.||.||:..:.:.|.|.|.|.|.......|.:.:.|.
Frog   186 TSNDYFALEVQTYTHMSKAVQ--LVLKKPLDREQIPFYNLTLTASDGGKPKLRGTAQLLITVQDV 248

  Fly   243 DDQNPKFQRESYSAEIPADGRPGELRMRPEPLKAVDQDEGICAPIQYTI---VQSQDAKYFRIHP 304
            :|..|.|.:..|.|.:..:...|....:   :.|.|.|:|....|.|..   |.......|.|..
Frog   249 NDNAPVFDQPFYRASLLENALKGTFVFK---VNATDLDQGENGQIYYAFSNKVTPDIISTFTIDK 310

  Fly   305 HNGAISLLTPI-----------------GYADVANGATLVVKATQI-DNPDRYALTTVQLTRPGS 351
            ..|.|.::..:                 |...:|....::|....: |||....:|::.:..|
Frog   311 DTGIIQVIGDVDFEVNNFYEIEVNAIDKGLYAMAGHCKVLVNILDVNDNPPMIIVTSLNVPVP-- 373

  Fly   352 HSDLSTLAFVQKRFVMRIREDTAVGNRILAL-----PTNKPGK---HLKYVIP---DPVNSQFFS 405
                               ||...|..:..:     .:.:.||   |:...:|   .|...:|:|
Frog   374 -------------------EDLPPGTVVAVISVHDRDSGQNGKVTCHISKNVPFKISPTLREFYS 419

  Fly   406 VGSLGELVLAKPLDYEKMTKHEFQVLATDGMT---NSTAELTLEVIDVNDWEPRFRETHYEFMVP 467
                  |.:...||:||..::|..:.|||..:   :.:..:.::|.||||..|.|.:       .
Frog   420 ------LTVDGTLDHEKTAEYELVITATDDGSVHLSDSKTIGIQVSDVNDNAPTFHQ-------G 471

  Fly   468 KSSLQSRADSFEGVLIGKVEAADGD--RNDKLELSLRGQHAGLFEIDSTGNIYMRPEQ-----LQ 525
            ..::..:.::..|..:..|.|:|.|  .|..:..||.........|.|  .|.:.||.     |.
Frog   472 LETINIKENNPPGSHVYTVSASDSDTGHNSFITYSLSDSFIDGIPISS--YISVNPENGKIFALL 534

  Fly   526 SLNESTVHLIAI---ATDTGVPPRSTSVPVSVTMEGLTLARSGWNSNMLGMFGMIMGLFLMIIVA 587
            |.:...|.....   |||.|:||.|.::.:.:.:|.:       |.|.    ...:..|.:...|
Frog   535 SFDHEQVRYFQCQIKATDAGLPPLSGNLTLHIFIEDI-------NDNS----PSALAPFSITESA 588

  Fly   588 LSCYIVRSKKQGK 600
            ::..:.||.|.|:
Frog   589 VTEMVPRSSKVGQ 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Cb	NP_001287524.1	Cadherin_repeat	46..137	CDD:206637	18/99 (18%)
		Cadherin_repeat	145..244	CDD:206637	35/104 (34%)
		Cadherin_repeat	253..347	CDD:206637	21/114 (18%)
		Cadherin_repeat	365..452	CDD:206637	22/100 (22%)
		Cadherin_repeat	461..555	CDD:206637	23/103 (22%)
LOC105946889	XP_012815606.2	Cadherin_2	43..125	CDD:400525	14/96 (15%)
		Cadherin_repeat	151..251	CDD:206637	35/104 (34%)
		Cadherin_repeat	260..359	CDD:206637	17/101 (17%)
		Cadherin_repeat	367..464	CDD:206637	24/123 (20%)
		Cadherin_repeat	474..574	CDD:206637	25/108 (23%)
		Cadherin_repeat	593..680	CDD:206637	4/9 (44%)
		Cadherin_C_2	705..783	CDD:406805
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	119	1.000	Inparanoid score	I4624
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050