DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alg9 and algn-9

DIOPT Version :9

Sequence 1:	NP_651353.1	Gene:	Alg9 / 43031	FlyBaseID:	FBgn0039293	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_496282.2	Gene:	algn-9 / 174633	WormBaseID:	WBGene00007556	Length:	603	Species:	Caenorhabditis elegans

Alignment Length:	612	Identity:	228/612 - (37%)
Similarity:	334/612 - (54%)	Gaps:	64/612 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 KKPPKRPGLNGNNKTKEATPAGKKKDKDAK---KRNQPTSGGQEKGLPNPIMPSVQTAFKTFVSA 83
            :|||.|      ...:.:..|.|||.|..|   |.|.|         .|....|..:.||..:|.
Worm    14 QKPPPR------IVDRSSFDADKKKIKVEKLYHKANNP---------DNDWPFSFGSVFKMLLSI 63

  Fly    84 RLCSAIWAYIADCDETFNYWEPLHYIINGHGLQTWEYSPQFGLRSYTYLLLQGVPGYFYQKLFNP 148
            |:..|||..|.||||.:|||||||..:.|.|.|||||||.:.:|||.|:.|..:|...:..||..
Worm    64 RISGAIWGIINDCDEVYNYWEPLHLFLYGEGFQTWEYSPVYAIRSYFYIYLHYIPASLFANLFGD 128

  Fly   149 SPILIFYMVRCMLGFGCAVMERYMYKSICQEFGIHIGRLWLIFQLFSVGMFVSSTALLPSSFSMY 213
            :.|::|.::|..:|..|.:.|.|.:.:||::..|..||.:::|.:||.|||::|||.:||||.|.
Worm   129 TKIVVFTLIRLTIGLFCLLGEYYAFDAICKKINIATGRFFILFSIFSSGMFLASTAFVPSSFCMA 193

  Fly   214 FGCAALAAWWQQNYCFAIFLTAISALLGWPFAALIGIPLVLEMLLRQRDWKTFVQWTLISGATVA 278
            .....|.|:..:|:...||..|.|.::||||:|::|:|:|.:|||.:.....|:..:|:.|..:.
Worm   194 ITFYILGAYLNENWTAGIFCVAFSTMVGWPFSAVLGLPIVADMLLLKGLRIRFILTSLVIGLCIG 258

  Fly   279 IPMIAIDTSYFGKLTFAPLNIVWYNVFTSHGPNIFGTEPLSYYIINGFLNFNIIWLLALQLPIML 343
            ...:..|:.||||...|||||..|||.:..||:::|.||||:||.|.|.|:||: :.|......|
Worm   259 GVQVITDSHYFGKTVLAPLNIFLYNVVSGPGPSLYGEEPLSFYIKNLFNNWNIV-IFAAPFGFPL 322

  Fly   344 VIDYLIVPAKSKSTLNFPHYISLAPLYL-------WLLVFFAQPHKEERFLFPIYPLISLCGAIT 401
            .:.|......|:.. |...|...||:.|       |||:|.:|.||||||||||||.|:...|:.
Worm   323 SLAYFTKVWMSQDR-NVALYQRFAPIILLAVTTAAWLLIFGSQAHKEERFLFPIYPFIAFFAALA 386

  Fly   402 VDVYQRIFFRMKSVVFKIKAGVHYLDHSMFIAILVMVTSTLLGLSRVFALYRNYHAPMDLMLELN 466
            :|...|:..:        |.|:..:     ::||.::...:|..||.::::.||.:.:::...||
Worm   387 LDATNRLCLK--------KLGMDNI-----LSILFILCFAILSASRTYSIHNNYGSHVEIYRSLN 438

  Fly   467 -------QFKATPQYDPDVIYNVCIGKDWHRYPGSFFFP-----AKNFRLRFLKSEFRGMLPAYY 519
                   .||..  :||   ..||:||:|||:|.|||.|     .|...:||::|||||:||..:
Worm   439 AELTNRTNFKNF--HDP---IRVCVGKEWHRFPSSFFIPQTVSDGKKVEMRFIQSEFRGLLPKPF 498

  Fly   520 ---DEGQNATKVVQPYFNDLNQENEHMYFDYDRCDFLVDFDEGKYTALEPNYSKRSKDWSVMKSL 581
               |:....|:.:....|:||||....|.|.|.||::||.|..: :..||::.|...:|..:.||
Worm   499 LKSDKLVEVTRHIPTEMNNLNQEEISRYVDLDSCDYVVDVDMPQ-SDREPDFRKMEDNWKPVDSL 562

  Fly   582 PFLIPEKS---HKVLRAFYVPFLTDNH 605
            ||:...||   |.:|||||||||:..|
Worm   563 PFIDVSKSTGFHGLLRAFYVPFLSAKH 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alg9	NP_651353.1	Glyco_transf_22	75..498	CDD:281842	166/436 (38%)
algn-9	NP_496282.2	Glyco_transf_22	55..472	CDD:281842	166/436 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164613
Domainoid	1	1.000	314	1.000	Domainoid score	I701
eggNOG	1	0.900	-	-		E1_KOG2515
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6756
Inparanoid	1	1.050	387	1.000	Inparanoid score	I1158
Isobase	1	0.950	-	0.993157	Normalized mean entropy	S1560
OMA	1	1.010	-	-		QHG54143
OrthoDB	1	1.010	-	-		D1396421at2759
OrthoFinder	1	1.000	-	-		FOG0005223
OrthoInspector	1	1.000	-	-		oto18043
orthoMCL	1	0.900	-	-		OOG6_103457
Panther	1	1.100	-	-	LDO	PTHR22760
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R46
SonicParanoid	1	1.000	-	-		X3737
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	16	15.790