DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alg9 and Alg9

DIOPT Version :9

Sequence 1:	NP_651353.1	Gene:	Alg9 / 43031	FlyBaseID:	FBgn0039293	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_598742.1	Gene:	Alg9 / 102580	MGIID:	1924753	Length:	611	Species:	Mus musculus

Alignment Length:	607	Identity:	270/607 - (44%)
Similarity:	382/607 - (62%)	Gaps:	32/607 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 GLNGNNKTKEATPAGKKKD----KDAKKRNQPTSG---GQEKGLPNPIMPSVQTAFKTFVSARLC 86
            |..|.....:|.||.:|.:    ::|....:|.||   ||...      |...||||..:|||||
Mouse    13 GGGGGGGGGDAGPAAEKLEQLGSREAGAEPRPESGNKAGQVWA------PEGSTAFKCLLSARLC 71

  Fly    87 SAIWAYIADCDETFNYWEPLHYIINGHGLQTWEYSPQFGLRSYTYLLLQGVPGYFYQKLFNPSPI 151
            :|:.:.|:|||||||||||.||:|.|.|.|||||||.:.:|||.||||...|..|:.::...:.|
Mouse    72 AALLSNISDCDETFNYWEPTHYLIYGKGFQTWEYSPVYAIRSYAYLLLHAWPAAFHARILQTNKI 136

  Fly   152 LIFYMVRCMLGFGCAVMERYMYKSICQEFGIHIGRLWLIFQLFSVGMFVSSTALLPSSFSMYFGC 216
            |:||.:||:|.|...|.|.|.||::|::||:|:.|:.|.|.:.|.|||.||:|.|||||.||...
Mouse   137 LVFYFLRCLLAFVSCVCELYFYKAVCKKFGLHVSRMMLAFLVLSTGMFCSSSAFLPSSFCMYTTL 201

  Fly   217 AALAAWWQQNYCFAIFLTAISALLGWPFAALIGIPLVLEMLLRQRDWKTFVQWTLISGATVAIPM 281
            .|:..|:......|:...|..|:|||||:|.:|:|:..::|.|:..||:|:.|:|::.|...:|:
Mouse   202 IAMTGWYMDKTPIAVLGVAAGAILGWPFSAALGLPIAFDLLARKHRWKSFLLWSLVALALFLVPV 266

  Fly   282 IAIDTSYFGKLTFAPLNIVWYNVFTSHGPNIFGTEPLSYYIINGFLNFNIIWLLA-LQLPIMLVI 345
            :.||:.|:|||..||||||.|||||||||:::||||..:|:||||||||:.:.|| |.||:..::
Mouse   267 VVIDSYYYGKLVVAPLNIVLYNVFTSHGPDLYGTEPWYFYLINGFLNFNVAFALALLVLPLTFLM 331

  Fly   346 DYLIVPAKSKSTLNFPHYISLAPLYLWLLVFFAQPHKEERFLFPIYPLISLCGAITVDVYQRIFF 410
            :||:.....:: |..|::::|||:|:|.::||.|||||||||||:||||.||||:.:...|:.:
Mouse   332 EYLLQRFHVQN-LGHPYWLTLAPMYIWFIIFFIQPHKEERFLFPVYPLICLCGAVALSALQKCY- 394

  Fly   411 RMKSVVFKIKAGVHYLDHSMFIAILVMVTSTLLGLSRVFALYRNYHAPMDLMLELNQFKATPQYD 475
               ..||:.....||...|.::|:..:....||..||..||:|.||.|:||..|..:. ||   |
Mouse   395 ---HFVFQRYRLEHYTVTSNWLALGTVFLFGLLSFSRSVALFRGYHGPLDLYPEFYRI-AT---D 452

  Fly   476 PDV-------IYNVCIGKDWHRYPGSFFFPAKNFRLRFLKSEFRGMLPAYYDEGQNATKVVQPYF 533
            |.:       ..|||:||:|:|:|.||..| .|::|:|:.|||||.||..:.||..||:.|..:.
Mouse   453 PTIHTVPEGRPVNVCVGKEWYRFPSSFLLP-DNWQLQFIPSEFRGQLPKPFAEGPLATRTVPTHM 516

  Fly   534 NDLNQENEHMYFDYDRCDFLVDFDEGKYTALEPNYSKRSKDWSVMKSLPFLIPEKSHKVLRAFYV 598
            ||.|:|....|.|..:|.:|||.|..:.|..|||||...::|..:...|||...:|.|:||||||
Mouse   517 NDQNREEPSRYIDISKCHYLVDLDTMRETPREPNYSSHREEWVSLAHRPFLDASRSSKLLRAFYV 581

  Fly   599 PFLTDNHIQYGDFNLLK-RKTK 619
            |||:|.:..|.::.:|| ||.|
Mouse   582 PFLSDQYTVYVNYTILKPRKAK 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alg9	NP_651353.1	Glyco_transf_22	75..498	CDD:281842	202/430 (47%)
Alg9	NP_598742.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51		12/44 (27%)
Alg9	NP_598742.1	Glyco_transf_22	60..482	CDD:281842	201/429 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846995
Domainoid	1	1.000	426	1.000	Domainoid score	I612
eggNOG	1	0.900	-	-		E1_KOG2515
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6756
Inparanoid	1	1.050	532	1.000	Inparanoid score	I1195
Isobase	1	0.950	-	0.993157	Normalized mean entropy	S1560
OMA	1	1.010	-	-		QHG54143
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005223
OrthoInspector	1	1.000	-	-		oto92705
orthoMCL	1	0.900	-	-		OOG6_103457
Panther	1	1.100	-	-	LDO	PTHR22760
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R46
SonicParanoid	1	1.000	-	-		X3737
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.780