DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31103 and SVOP

DIOPT Version :9

Sequence 1:	NP_001097914.1	Gene:	CG31103 / 43030	FlyBaseID:	FBgn0051103	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_061181.1	Gene:	SVOP / 55530	HGNCID:	25417	Length:	548	Species:	Homo sapiens

Alignment Length:	508	Identity:	115/508 - (22%)
Similarity:	202/508 - (39%)	Gaps:	97/508 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LEKIGYGKTQWVLLLVSGLLTITSVAAQQAMSIIVIASQCEFETTQAEKGVMMAASVTGIFLSTY 85
            :|.||:||.||.|.:::||..:........:||:.....||:.....:..::.:....|:..|:.
Human    74 VEAIGFGKFQWKLSVLTGLAWMADAMEMMILSILAPQLHCEWRLPSWQVALLTSVVFVGMMSSST 138

  Fly    86 IWGYISDDIGRRR--------VLLYGNFASNALQFVLMFVTSVWLFNIINLLVGISVGAV--SAA 140
            :||.|||..||:.        .|.||..::.|..:       .|:. ::..|||..:|.|  |..
Human   139 LWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVY-------SWIL-VLRGLVGFGIGGVPQSVT 195

  Fly   141 LYAYLSEFNIPRHRAVAINYSTMFVSVTAIYVPATAWLVLSSNWAITMGDFVFRPWRLLLLVSLL 205
            |||   ||...:.||..|....:|.::..::....|..|:.|     :|      ||.||::|.:
Human   196 LYA---EFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVMPS-----LG------WRWLLILSAV 246

  Fly   206 PGFIGGLILLYYPESPKFLLSQEKNNEAIEAVAWISKFNRGKSIQQVLSCDEFTLKSEDPVGENL 270
            |..:..::..:.|||.::.:......:||..:..|:..|....                |:|:.:
Human   247 PLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIATENGAPM----------------PLGKLI 295

  Fly   271 LGESQGCGILSKICRATIPLFHKPHGFNFILCNLALFGMFFSS----NGMQLWFPE--------- 322
            :...:..|.:..:        ..||   |....|.|:.::||:    .|:.|...|
Human   296 ISRQEDRGKMRDL--------FTPH---FRWTTLLLWFIWFSNAFSYYGLVLLTTELFQAGDVCG 349

  Fly   323 IVNRSSGAENNSSTVCEILSVPVEQPNVTETLDCTDPISSKTYIDNLVVGFAFLIGFSIQGLILN 387
            |.:|....|...|..||.|                   |.:.|:|.|....:...|..:...|::
Human   350 ISSRKKAVEAKCSLACEYL-------------------SEEDYMDLLWTTLSEFPGVLVTLWIID 395

  Fly   388 PLGRKNVLLAALAVATLSGVLLHFMESPTGVLVLFCLYILLPGLSISIMIGAIV--DLVPTHLRS 450
            .||||..:.....:.:...:|| |:.....||.|. |:|....:|.......:.  ::.||..|:
Human   396 RLGRKKTMALCFVIFSFCSLLL-FICVGRNVLTLL-LFIARAFISGGFQAAYVYTPEVYPTATRA 458

  Fly   451 KAVSFCMSLGRLGIIAATNLMGVMLQPYCNTTFAMFT-CTLIVCIVIVHYLPI 502
            ..:..|..:.|:|.:....:..|||:.....|.|::: |.|:..:... :|||
Human   459 LGLGTCSGMARVGALITPFIAQVMLESSVYLTLAVYSGCCLLAALASC-FLPI 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31103	NP_001097914.1	2A0115	29..475	CDD:273327	101/470 (21%)
CG31103	NP_001097914.1	MFS	34..>189	CDD:119392	38/164 (23%)
SVOP	NP_061181.1	MFS_SVOP	87..509	CDD:340999	104/492 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010