DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG31103 and SV2C

DIOPT Version :9

Sequence 1:NP_001097914.1 Gene:CG31103 / 43030 FlyBaseID:FBgn0051103 Length:506 Species:Drosophila melanogaster
Sequence 2:NP_055794.3 Gene:SV2C / 22987 HGNCID:30670 Length:727 Species:Homo sapiens


Alignment Length:583 Identity:122/583 - (20%)
Similarity:222/583 - (38%) Gaps:116/583 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 YDMVLEKIGYGKTQWVLLLVSGLLTITSVAAQQAMSIIVIASQCEFETTQAEKGVMMAASVTGIF 81
            |::::::.|:|:.||.|..|.|:..:........:..::.:::.:.....:..|.:.:....|:.
Human   138 YELIIQECGHGRFQWALFFVLGMALMADGVEVFVVGFVLPSAETDLCIPNSGSGWLGSIVYLGMM 202

  Fly    82 LSTYIWGYISDDIGRRRVLLYGNFASNALQFVLMFVTSVWLFNIINLLVGISVGAVSAALYAYLS 146
            :..:.||.::|.:||::.||.....:....|:..||.....|....||.|..:|.....:::|.:
Human   203 VGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLSGFGIGGAIPTVFSYFA 267

  Fly   147 EFNIPRHRAVAINYSTMFVSVTAIYVPATAWLVLSS-NWAITMGD-FVFRPWRLLLLVSLLPGFI 209
            |......|...:::..||..:..||..|.||.::.. .|:.:||. :.|..||:.::|..||...
Human   268 EVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCVS 332

  Fly   210 GGLILLYYPESPKFLLSQEKNNEA-----------------IEAVAWISKFNRGKSIQQVLSCDE 257
            ..:.|.:.||||:|||...|::||                 .|.|..::|....|.|.:::..:.
Human   333 SVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTVNKIKTPKQIDELIEIES 397

  Fly   258 FTLKSEDPVGENLLGESQGCGILSKICRATIPLFHKPHGFNFILCNLALFGMFFSSNGMQLWFPE 322
            .|..........:..|..|..:....|      |:.|...|.|...:..|.:.|...|:.:|||:
Human   398 DTGTWYRRCFVRIRTELYGIWLTFMRC------FNYPVRDNTIKLTIVWFTLSFGYYGLSVWFPD 456

  Fly   323 I---------------VNRSSGA--------EN----------------------------NSST 336
            :               |.|...|        ||                            .|.|
Human   457 VIKPLQSDEYALLTRNVERDKYANFTINFTMENQIHTGMEYDNGRFIGVKFKSVTFKDSVFKSCT 521

  Fly   337 VCEILSVPVEQPNVT---ETLDCTD--P-------------ISSKT---------------YIDN 368
            ..::.||.....|.|   ...|.||  |             ..:||               |..|
Human   522 FEDVTSVNTYFKNCTFIDTVFDNTDFEPYKFIDSEFKNCSFFHNKTGCQITFDDDYSAYWIYFVN 586

  Fly   369 LVVGFAFLIGFSIQGLILNPLGRKNVLLAALAVATLSGVLLHFMESPTGVLVLFCLYILLPGLSI 433
            .:...|.|.|..:..|:::.:||..:|..::.::.:|...|.|..|.:.::.:.|||   .||:|
Human   587 FLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLY---NGLTI 648

  Fly   434 SI---MIGAIVDLVPTHLRSKAVSFCMSLGRLGIIAATNLMGVMLQPYCNTTFAMFTCTLIVC 493
            |.   :....|:|.||..|:....|..:|.:...:....:.|.::. ...:...:...|::||
Human   649 SAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVS-ITKSIPILLASTVLVC 710

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31103NP_001097914.1 2A0115 29..475 CDD:273327 116/551 (21%)
MFS 34..>189 CDD:119392 30/155 (19%)
SV2CNP_055794.3 synapt_SV2 1..727 CDD:130366 122/583 (21%)
Interaction with SYT1. /evidence=ECO:0000250 1..57
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 24..84
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 109..128
MFS 155..719 CDD:119392 116/566 (20%)
Pentapeptide_3 507..561 CDD:290309 10/53 (19%)
(Microbial infection) C.botulinum neurotoxin type A-binding. /evidence=ECO:0000269|PubMed:27294781 519..563 10/43 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D208328at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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