DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG31103 and SV2C

DIOPT Version :10

Sequence 1:NP_001097914.1 Gene:CG31103 / 43030 FlyBaseID:FBgn0051103 Length:506 Species:Drosophila melanogaster
Sequence 2:NP_055794.3 Gene:SV2C / 22987 HGNCID:30670 Length:727 Species:Homo sapiens


Alignment Length:583 Identity:122/583 - (20%)
Similarity:222/583 - (38%) Gaps:116/583 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 YDMVLEKIGYGKTQWVLLLVSGLLTITSVAAQQAMSIIVIASQCEFETTQAEKGVMMAASVTGIF 81
            |::::::.|:|:.||.|..|.|:..:........:..::.:::.:.....:..|.:.:....|:.
Human   138 YELIIQECGHGRFQWALFFVLGMALMADGVEVFVVGFVLPSAETDLCIPNSGSGWLGSIVYLGMM 202

  Fly    82 LSTYIWGYISDDIGRRRVLLYGNFASNALQFVLMFVTSVWLFNIINLLVGISVGAVSAALYAYLS 146
            :..:.||.::|.:||::.||.....:....|:..||.....|....||.|..:|.....:::|.:
Human   203 VGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLSGFGIGGAIPTVFSYFA 267

  Fly   147 EFNIPRHRAVAINYSTMFVSVTAIYVPATAWLVLSS-NWAITMGD-FVFRPWRLLLLVSLLPGFI 209
            |......|...:::..||..:..||..|.||.::.. .|:.:||. :.|..||:.::|..||...
Human   268 EVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCVS 332

  Fly   210 GGLILLYYPESPKFLLSQEKNNEA-----------------IEAVAWISKFNRGKSIQQVLSCDE 257
            ..:.|.:.||||:|||...|::||                 .|.|..::|....|.|.:::..:.
Human   333 SVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTVNKIKTPKQIDELIEIES 397

  Fly   258 FTLKSEDPVGENLLGESQGCGILSKICRATIPLFHKPHGFNFILCNLALFGMFFSSNGMQLWFPE 322
            .|..........:..|..|..:....|      |:.|...|.|...:..|.:.|...|:.:|||:
Human   398 DTGTWYRRCFVRIRTELYGIWLTFMRC------FNYPVRDNTIKLTIVWFTLSFGYYGLSVWFPD 456

  Fly   323 I---------------VNRSSGA--------EN----------------------------NSST 336
            :               |.|...|        ||                            .|.|
Human   457 VIKPLQSDEYALLTRNVERDKYANFTINFTMENQIHTGMEYDNGRFIGVKFKSVTFKDSVFKSCT 521

  Fly   337 VCEILSVPVEQPNVT---ETLDCTD--P-------------ISSKT---------------YIDN 368
            ..::.||.....|.|   ...|.||  |             ..:||               |..|
Human   522 FEDVTSVNTYFKNCTFIDTVFDNTDFEPYKFIDSEFKNCSFFHNKTGCQITFDDDYSAYWIYFVN 586

  Fly   369 LVVGFAFLIGFSIQGLILNPLGRKNVLLAALAVATLSGVLLHFMESPTGVLVLFCLYILLPGLSI 433
            .:...|.|.|..:..|:::.:||..:|..::.::.:|...|.|..|.:.::.:.|||   .||:|
Human   587 FLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLY---NGLTI 648

  Fly   434 SI---MIGAIVDLVPTHLRSKAVSFCMSLGRLGIIAATNLMGVMLQPYCNTTFAMFTCTLIVC 493
            |.   :....|:|.||..|:....|..:|.:...:....:.|.::. ...:...:...|::||
Human   649 SAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVS-ITKSIPILLASTVLVC 710

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31103NP_001097914.1 synapt_SV2 <17..>324 CDD:130366 74/340 (22%)
SV2CNP_055794.3 synapt_SV2 1..727 CDD:130366 122/583 (21%)
Interaction with SYT1. /evidence=ECO:0000250 1..57
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 24..84
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 109..128
(Microbial infection) C.botulinum neurotoxin type A-binding. /evidence=ECO:0000269|PubMed:27294781 519..563 10/43 (23%)
Blue background indicates that the domain is not in the aligned region.

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