DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31103 and Slc22a25

DIOPT Version :9

Sequence 1:	NP_001097914.1	Gene:	CG31103 / 43030	FlyBaseID:	FBgn0051103	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_620263.1	Gene:	Slc22a25 / 192273	RGDID:	621104	Length:	552	Species:	Rattus norvegicus

Alignment Length:	487	Identity:	103/487 - (21%)
Similarity:	188/487 - (38%)	Gaps:	107/487 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 DYDMVLEKI-GYGKTQWVLLLVSGLLTITSVAA------------QQAMSIIVIASQ----CEFE 63
            |.|:..||. .:.:.||.||.::|  |.:||..            .|:..:..|.::    ||
  Rat    80 DSDLRPEKCRRFVQPQWDLLHLNG--TFSSVTEPDTEPCVDGWVYDQSTFLSTIITEWDLVCE-- 140

  Fly    64 TTQAEKGVMMAASVTGIFLSTYIWGYISDDIGRRRVLLYGNFASNALQFVLMFVTSVWLFNIINL 128
             :|:...:.....:|||.:...::|.::|..|||.:|:..:......:....|..:..::..:..
  Rat   141 -SQSLDSIAKFLFLTGILVGNILYGPLTDRFGRRLILICASLQMAVTETCAAFAPTFLIYCSLRF 204

  Fly   129 LVGISVGAVSAALYAYLSEFNIPRHRAVAINYSTMFVSVTAIYVPATAWLVLSSNWAITMGDFVF 193
            |.|||...|.......:.|:..|:.:|:|   :.:.:...||.....|.|.           |..
  Rat   205 LAGISFSTVLTNSALLIIEWTRPKFQALA---TGLLLCAGAIGQTVLAGLA-----------FTV 255

  Fly   194 RPWRLLLLVSLLPGFIGGLILLYYPESPKFLLSQEKNNEAIEAVAWISKFNRGKSIQQVLSCDEF 258
            |.|..|.|...:|.|...:...:..||.::|:...|..:.::.:..::..|..|:...||:.:..
  Rat   256 RNWHHLHLAMSVPIFFLLVPTRWLSESARWLIMTNKLQKGLKELIKVAHINGMKNSTDVLTIEVV 320

  Fly   259 -TLKSEDPVGENLLGESQGCGILSKICRATIPLFHKPHGFNFILCNLALFGMFFSSNGMQLWFPE 322
             |:..|:      |..||....|..:.|.  |...|    ...|.:|..|.::.|..|:
  Rat   321 RTIMKEE------LEASQTKSSLWDLFRT--PNLRK----RICLLSLVRFVVWLSVIGL------ 367

  Fly   323 IVNRSSGAENNSSTVC--EILSVPVEQPNVTETLDCTDPISSKTYIDNLVVGFAFLIGFSIQGLI 385
            ::|......|.....|  .|:::|                             |.|:|.    .:
  Rat   368 LINFQHLRINVFLLQCLLGIITIP-----------------------------ANLVGI----FL 399

  Fly   386 LNPLGRKNVLLAALAVATLSGV-LLHFMESPTGVLVLFCLYILLPG----LSISIMIGAIVDLVP 445
            :|.|||:   ::.|.:.:|.|: :|..:..|..:.:|..:.....|    :|:|..:....:|:|
  Rat   400 VNHLGRR---ISQLFIISLFGISILAIIFVPQEMQILRMVLATFGGVFSFVSVSSALVHANELLP 461

  Fly   446 THLRSKAVSFCMSLGRLGIIAATNLMGVMLQP 477
            |.:|:.|      ||.:||..:|   |..|.|
  Rat   462 TIIRATA------LGVIGIAGST---GAALSP 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31103	NP_001097914.1	2A0115	29..475	CDD:273327	97/469 (21%)
CG31103	NP_001097914.1	MFS	34..>189	CDD:119392	33/170 (19%)
Slc22a25	NP_620263.1	2A0119	11..525	CDD:273328	103/487 (21%)
		Aldolase_II	39..>85	CDD:294146	2/4 (50%)
		MFS	125..506	CDD:119392	90/440 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346971
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840