Protein Alignment FOXO4 and FKH2

DIOPT Version :10

• Sequence 1: NP_005929.2
• Gene: FOXO4 / 4303
• HGNCID: 7139
• Length: 505
• Species: Homo sapiens
• Sequence 2: NP_014331.3
• Gene: FKH2 / 855656
• SGDID: S000005012
• Length: 862
• Species: Saccharomyces cerevisiae
• Alignment Length: 436
• Identity: 103/436 - (23%)
• Similarity: 159/436 - (36%)
• Gaps: 129/436 - (29%)

Human    98 RNAWGNQSYAELISQAIESAPEKRLTLAQIYEWMVRTVPYFKDKGDSNSSAGWKNSIRHNLSLHS 162
            ||.....|||.:|:|||.|:||..::||.||:::.....|::     .:.:||:|||||||||:.
Yeast   337 RNVKPPHSYATMITQAILSSPEGVISLADIYKYISSNYAYYR-----FAKSGWQNSIRHNLSLNK 396

Human   163 KFIKV---HNEATGKSSWWMLNP----------EGGKSGKAPRRRAAS----------------M 198
            .|.||   .|| .||...|.::.          ..||.||.  ||.:|                |
Yeast   397 AFEKVPRRPNE-PGKGMKWRISESYQQEFLNKWNTGKVGKI--RRGSSVARQLQLHMAKFNSLPM 458

Human   199 DSSSKLLRGRSKAPKK--------KPS--------VLPAPPEGATPTS-----PVGHFAKWSGSP 242
            :...:|....::.||:        :||        |...|.:|..|.|     ||.|..:....|
Yeast   459 EMDYRLSLNMAQPPKRQLQSHNVLEPSNNNIIEGFVQHVPSKGNLPASQQSQPPVSHQNQSQQPP 523

Human   243 CSRNREEADMWTTFRPRSSSNASSVSTRLSPLRPESEVLAEEIPASVSSYAGGVPPTLNEGLELL 307
            ....|:|...  ||....:.|.:               ||..|..
Yeast   524 PQEQRQEIQF--TFADTQNRNIA---------------LARPIKT-------------------- 551

Human   308 DGLNLTSSHSLLSRSGLSGF--SLQHPGVTGPLHTYSSSLFSPAEGPLSAGEGCFSSSQALEALL 370
            ..|...:|::.|:::.:..:  ||..|.::    ....:..||....:|....| ::|:.:..:
Yeast   552 PQLQAPNSNANLNQNNMKEYKESLHPPAIS----ISQMNRQSPNNALVSFTNAC-ANSKIINNI- 610

Human   371 TSDTPPPPADVLMTQVDPILSQAPTLLLLGGLPSSSKLATGVGLCPKPLEAPGPSSLVP----TL 431
             ||:    ||.............|.:       |:|.|.....|.|....:.|.|:.||    |.
Yeast   611 -SDS----ADKSTNNNGGTKMNLPAI-------STSSLDENGNLEPTTTTSSGNSNSVPQTGTTT 663

Human   432 SMIAPPPVMASAPIPKALGTP----------VLTPPTEAASQDRMP 467
            |.:|...:..|.|....|.:|          ..||...:|::.|.|
Yeast   664 SSLAANSLRLSQPYDTLLRSPTKAFHITAMEAYTPERGSANRARSP 709

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FOXO4	NP_005929.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..100		1/1 (100%)
		FH_FOXO4	98..183	CDD:410836	36/97 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	176..246		23/116 (20%)
		FOXO_KIX_bdg	<358..393	CDD:465228	6/34 (18%)
		FOXO-TAD	465..503	CDD:435506	2/3 (67%)
FKH2	NP_014331.3	COG5025	1..610	CDD:227358	77/322 (24%)