Protein Alignment FOXO4 and FKH1

DIOPT Version :10

• Sequence 1: NP_005929.2
• Gene: FOXO4 / 4303
• HGNCID: 7139
• Length: 505
• Species: Homo sapiens
• Sequence 2: NP_012135.1
• Gene: FKH1 / 854675
• SGDID: S000001393
• Length: 484
• Species: Saccharomyces cerevisiae
• Alignment Length: 280
• Identity: 66/280 - (23%)
• Similarity: 105/280 - (37%)
• Gaps: 103/280 - (36%)

Human    93 KGGSRRNAW----------GN---------------------QSYAELISQAIESAPEKRLTLAQ 126
            :||.|.|.:          ||                     ||||.:|:|||.|.||..::||.
Yeast   264 RGGIRPNTYTSSSNNAVTNGNVPHIENPSDLSLDENRYIKPPQSYASMITQAILSTPEGSISLAD 328

Human   127 IYEWMVRTVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIKVHNEA--TGKSSWWMLNPE------ 183
            ||:::.....:::     .|...|:||:||||||:..|.||...|  .||...|.::.|
Yeast   329 IYKFISDNYAFYR-----FSQMAWQNSVRHNLSLNKAFEKVPKRAGQQGKGMNWKISDEVRRDFL 388

Human   184 ----GGKSGKAPRRRAASMDSSSKLLRGRSKAPKKKPSVLPAPPEGATPTSPVGHFAKWSGSPCS 244
                .||..|.  ||.||:....:|                             |.:|:...|.
Yeast   389 NKWNAGKLSKI--RRGASVTRQLQL-----------------------------HMSKFGEIPA- 421

Human   245 RNREEADMWTTFRPRSSSNASSVSTRLSPLRPESEVLAEEIPASVSSYAGGVPPTLNEGLELLDG 309
                         |.|||        :.|...:::.:.:.:.|: ||..|...|.| :..:|...
Yeast   422 -------------PESSS--------IDPRGIKAQKVKKSLQAT-SSILGESAPQL-QRTQLTGQ 463

Human   310 LNLTSSHSLLSRSGLSGFSL 329
            ::.|:|..:.:.:.::..||
Yeast   464 ISTTTSMDVTTNANVNNSSL 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FOXO4	NP_005929.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..100		3/6 (50%)
		FH_FOXO4	98..183	CDD:410836	35/117 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	176..246		13/79 (16%)
		FOXO_KIX_bdg	<358..393	CDD:465228
		FOXO-TAD	465..503	CDD:435506
FKH1	NP_012135.1	COG5025	1..484	CDD:227358	66/280 (24%)