Protein Alignment FOXO4 and HCM1

DIOPT Version :10

• Sequence 1: NP_005929.2
• Gene: FOXO4 / 4303
• HGNCID: 7139
• Length: 505
• Species: Homo sapiens
• Sequence 2: NP_009991.2
• Gene: HCM1 / 850429
• SGDID: S000000661
• Length: 564
• Species: Saccharomyces cerevisiae
• Alignment Length: 558
• Identity: 126/558 - (22%)
• Similarity: 182/558 - (32%)
• Gaps: 203/558 - (36%)

Human     4 GNENSATEAAAII------DLDPDFEPQSRPRSCTWPLPRPEIANQPSEPPEVEPDLGEKVHTEG 62
            |:.:..||.:.::      .|: |.:....|.|.|......|:..:||.|  :.||
Yeast    11 GHNSFLTEKSTVLLTQAKRTLE-DEKEMITPPSSTVRKTMKEVNKRPSHP--LSPD--------- 63

Human    63 RSEPILLPSRLPEPAGGPQPGILGAVTGPRKGGS-----------RRNAWGN------QSYAELI 110
            .|.|| .||:.......         |..|..|:           ||...|.      .|||.||
Yeast    64 HSSPI-APSKAKRQRSD---------TCARSNGNLTLEEILQSLERRRINGELAKKPPYSYATLI 118

Human   111 SQAIESAPEKRLTLAQIYEWMVRTVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIKVHNEATGKS 175
            ..||..:.|.:|||:|||.|:....||:|.|     .|.|:|||||||||:..|||......||.
Yeast   119 CLAILQSQEGKLTLSQIYHWIHVHFPYYKQK-----DASWQNSIRHNLSLNDAFIKTEKSCDGKG 178

Human   176 SWWMLNP----------------------------------------EGGKSG-----KAPRRRA 195
            .:|.:.|                                        |.|:..     :..|..|
Yeast   179 HFWEVRPGAETKFFKGENRGYEFVKDSLQDIGKYFEIDSTLDELEQVESGEGNDDLPDEEEREEA 243

Human   196 ASMDS------SSKLLRGRS--KAPKKK------------------------------------- 215
            ....|      ||.:||...  ..|:.|
Yeast   244 GKFPSIEIQLNSSPILRVSQLHHIPQLKTDNSVLNPHENLESMRNMIENDVNNIDSLEPPYVMKK 308

Human   216 -------PSVLPAPP--EGATPTSPVGHFAKWSGSPCSRNREEADM---WTTFRP--------RS 260
                   ||::.|..  :.....:.:....:::..|.:..:...:.   :|:|..        ||
Yeast   309 YHTSLGLPSLVNAKDHFQAGVKNNNITQANRFNTLPITSAKSPQNFRKYFTSFNSNFEDLSPLRS 373

Human   261 SSNASSVSTRL--SPLR--PESEVLAEEIPASVSSYAGG--VPPTLNEGLELL--------DGLN 311
            :..|.|:...|  |||:  .:..:.....|.|..||:..  .||..:.|.:||        |||.
Yeast   374 NVGAGSLLDPLPYSPLKLYDQKNLALMSKPQSQQSYSNSQLPPPPSSHGSDLLKTPKMRHSDGLE 438

Human   312 LTSSHSLLSRSGLSGFSLQHPGVTGPLH----TYSSSLFSPAEGPLSAGEGCFSSSQALEALLTS 372
            .|.|.  |..:...|.|:.....| |.|    .|.|.||...|.|:              ..:|:
Yeast   439 KTPSR--LISTPKDGNSILRKWQT-PSHLFEDLYCSPLFRAIETPI--------------RYITT 486

Human   373 DTPPPPADVLMTQVDPILSQAPTLLLLGGLPSSSKLAT 410
                 |...|.||:.|..|.||.:|...   ::||.|:
Yeast   487 -----PGGTLETQISPRKSSAPDVLTSA---TNSKFAS 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FOXO4	NP_005929.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..100		24/112 (21%)
		FH_FOXO4	98..183	CDD:410836	39/130 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	176..246		17/168 (10%)
		FOXO_KIX_bdg	<358..393	CDD:465228	7/34 (21%)
		FOXO-TAD	465..503	CDD:435506
HCM1	NP_009991.2	COG5025	20..564	CDD:227358	123/549 (22%)