Protein Alignment FOXO4 and foxo4

DIOPT Version :10

• Sequence 1: NP_005929.2
• Gene: FOXO4 / 4303
• HGNCID: 7139
• Length: 505
• Species: Homo sapiens
• Sequence 2: XP_009289443.1
• Gene: foxo4 / 563719
• ZFINID: ZDB-GENE-150311-1
• Length: 626
• Species: Danio rerio
• Alignment Length: 609
• Identity: 272/609 - (44%)
• Similarity: 345/609 - (56%)
• Gaps: 138/609 - (22%)

Human    18 LDPDFEPQSRPRSCTWPLPRPEIA------NQPSEPPEVEPDLGEKVHTEGRSEPILL-PSRLPE 75
            :|||||||:||||||||||||:|:      ...||.....|...|..|.   .:||:. |.::..
Zfish     9 IDPDFEPQTRPRSCTWPLPRPDISAVKAGGTDGSESAAGTPPAEEDKHD---PQPIICDPEKIAV 70

Human    76 PAGGPQPGILGAVTGPRKGGSRRNAWGNQSYAELISQAIESAPEKRLTLAQIYEWMVRTVPYFKD 140
            ..||...|:.||.  ||||.||||||||||||:|||||||::|||||||||||:|||:|||||||
Zfish    71 SEGGLVAGVGGAT--PRKGSSRRNAWGNQSYADLISQAIENSPEKRLTLAQIYDWMVKTVPYFKD 133

Human   141 KGDSNSSAGWKNSIRHNLSLHSKFIKVHNEATGKSSWWMLNPEGGKSGKAPRRRAASMDSSSKLL 205
            |||||||||||||||||||||:||::||||:|||||||||||||||:|||.||||.|||:|.|||
Zfish   134 KGDSNSSAGWKNSIRHNLSLHNKFLRVHNESTGKSSWWMLNPEGGKTGKAHRRRATSMDNSGKLL 198

Human   206 RGRSKAPKKKPSVLPA---------PPEGATPT------SPVGHFAKW---SGSPCSR-NREEAD 251
            :.|.:|.:.|.....|         ..||.:.|      .|.|.|.||   |.||.|| :.::.|
Zfish   199 KSRIRAKQTKKQAGAAGIGGTGGGLQGEGTSGTGNADSPGPPGQFGKWGVNSSSPSSRGSLDDPD 263

Human   252 MWTTFRPRSSSNASSVSTRLSPLRPESEVLAEEIPAS--VSSYAGG-----VPPTLNEGLELLDG 309
            :||:.|||:|||||::|.||||:....|. .:::|..  :..|:.|     :|.||.|.|:|:||
Zfish   264 IWTSIRPRTSSNASTLSGRLSPIATGQED-EDDLPEDGLLGGYSSGNLPSTLPETLMEELDLIDG 327

Human   310 LN---------------------LTSSHSLLSR-SGLSGFSLQHP-----GVT--GPLHT----- 340
            |.                     |.|:.:||.| |....|....|     |.|  ||..:
Zfish   328 LTLMTAPQGGASPSMAPPAPPQPLPSASTLLPRGSSFPSFRQLQPTKASQGSTPPGPQSSVQPNA 392

Human   341 ---------YSSSLFSPAEGPLSAGEGCFSS--SQALEALLTSDTPPPPADVLMTQVDPIL-SQ- 392
                     :.:|||||..||   |...||:  ..:||||||||: |||:||:|||:||:: ||
Zfish   393 GSSTSSPSNFGNSLFSPLPGP---GHSGFSTHVPSSLEALLTSDS-PPPSDVMMTQMDPLMPSQG 453

Human   393 APTLLLLGGLPSSSKLATGVGLCPKPLEAPGPSSLVPTLSMIAPPPV-------------MASAP 444
            ...||.|||..|||::..|..:..|.::    :|.|..:|:..||.:             |:..|
Zfish   454 GGGLLGLGGSMSSSQVKAGQMMLSKGID----TSTVGQMSLQRPPQLQHSQMGFGMMHMAMSQEP 514

Human   445 ----------------------IPKALGTPVL-------TPPTEAASQDRMPQDLDLDMYMENLE 480
                                  ||...|...|       |.|....||||:|.|||:||:.|||:
Zfish   515 PQLSTVKTQHQVPGSGLLHHGVIPSPAGNGGLQGLGQFSTMPCFIPSQDRLPTDLDIDMFTENLD 579

Human   481 CDMDNII-SDLMDEGEGLDFNFEP 503
            ||::.|| ||||| |:.:||||:|
Zfish   580 CDVEYIINSDLMD-GDLVDFNFDP 602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FOXO4	NP_005929.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..100		40/88 (45%)
		FH_FOXO4	98..183	CDD:410836	75/84 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	176..246		42/88 (48%)
		FOXO_KIX_bdg	<358..393	CDD:465228	22/38 (58%)
		FOXO-TAD	465..503	CDD:435506	24/38 (63%)
foxo4	XP_009289443.1	FH_FOXO4	91..176	CDD:410836	75/84 (89%)
		FOXO_KIX_bdg	375..>450	CDD:465228	32/78 (41%)
		FOXO-TAD	564..603	CDD:435506	25/40 (63%)