Protein Alignment FOXO4 and Foxo4

DIOPT Version :10

• Sequence 1: NP_005929.2
• Gene: FOXO4 / 4303
• HGNCID: 7139
• Length: 505
• Species: Homo sapiens
• Sequence 2: NP_061259.1
• Gene: Foxo4 / 54601
• MGIID: 1891915
• Length: 505
• Species: Mus musculus
• Alignment Length: 506
• Identity: 447/506 - (88%)
• Similarity: 470/506 - (92%)
• Gaps: 2/506 - (0%)

Human     1 MDPGNENSATEAAAIIDLDPDFEPQSRPRSCTWPLPRPEIANQPSEPPEVEPDLGEKVHTEGRSE 65
            |||.|:.|||.||||:||||||||||||||||||||||::|.:|.||.||||.||:||.|||.||
Mouse     1 MDPENKKSATGAAAILDLDPDFEPQSRPRSCTWPLPRPDLATEPHEPSEVEPSLGQKVPTEGHSE 65

Human    66 PILLPSRLPEPAGGPQPGILGAVTGPRKGGSRRNAWGNQSYAELISQAIESAPEKRLTLAQIYEW 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 PILLPSRLPEPAGGPQPGILGAVTGPRKGGSRRNAWGNQSYAELISQAIESAPEKRLTLAQIYEW 130

Human   131 MVRTVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIKVHNEATGKSSWWMLNPEGGKSGKAPRRRA 195
            ||||||||||||||||||||||||||||||||||||||||||||||||||||:|||.||||||||
Mouse   131 MVRTVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIKVHNEATGKSSWWMLNPDGGKGGKAPRRRA 195

Human   196 ASMDSSSKLLRGRSKAPKKKPSVLPAPPEGATPTSPVGHFAKWSGSPCSRNREEADMWTTFRPRS 260
            |||||||||||||||.|||||||||||||||||.||:|||||||.|||.|||||||:||||||||
Mouse   196 ASMDSSSKLLRGRSKGPKKKPSVLPAPPEGATPRSPLGHFAKWSSSPCPRNREEADVWTTFRPRS 260

Human   261 SSNASSVSTRLSPLRPESEVLA-EEIPASVSSYAGGVPPTLNEGLELLDGLNLTSSHSLLSRSGL 324
            |||||:|||||||:|||||||| ||:|||.|||||||||||:|.|||||||||.|.|||||||||
Mouse   261 SSNASTVSTRLSPMRPESEVLAEEEMPASASSYAGGVPPTLSEDLELLDGLNLASPHSLLSRSGL 325

Human   325 SGFSLQHPGVTGPLHTYSSSLFSPAEGPLSAGEGCFSSSQALEALLTSDTPPPPADVLMTQVDPI 389
            |||||||||:.||||:|.:|||.|.:|.||||||||||||:||||||||||||||||||||||||
Mouse   326 SGFSLQHPGLAGPLHSYGASLFGPIDGSLSAGEGCFSSSQSLEALLTSDTPPPPADVLMTQVDPI 390

Human   390 LSQAPTLLLLGGLPSSSKLATGVGLCPKPLEAPGPSSLVPTLSMIAPPPVMASAPIPKALGTPVL 454
            ||||||||||||:||||||.|||.|||.|||.||||:|||.||::|||||||.|||||.||||||
Mouse   391 LSQAPTLLLLGGMPSSSKLGTGVSLCPTPLEGPGPSNLVPNLSVMAPPPVMAGAPIPKVLGTPVL 455

Human   455 TPPTEAASQDRMPQDLDLDMYMENLECDMDNIISDLMDEGEGLDFNFEPDP 505
            ..|||.:|.||||||||||||||||||||||||||||| ||||||||||||
Mouse   456 ASPTEDSSHDRMPQDLDLDMYMENLECDMDNIISDLMD-GEGLDFNFEPDP 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FOXO4	NP_005929.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..100		83/98 (85%)
		FH_FOXO4	98..183	CDD:410836	84/84 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	176..246		62/69 (90%)
		FOXO_KIX_bdg	<358..393	CDD:465228	33/34 (97%)
		FOXO-TAD	465..503	CDD:435506	36/37 (97%)
Foxo4	NP_061259.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..66		49/64 (77%)
		Required for interaction with FOXK1. /evidence=ECO:0000269|PubMed:22956541	97..215		114/117 (97%)
		FH_FOXO4	98..183	CDD:410836	84/84 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	175..244		62/68 (91%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..276		16/18 (89%)
		FOXO_KIX_bdg	<359..399	CDD:465228	38/39 (97%)
		FOXO-TAD	466..503	CDD:435506	36/37 (97%)