Protein Alignment FOXO4 and foxo

DIOPT Version :10

• Sequence 1: NP_005929.2
• Gene: FOXO4 / 4303
• HGNCID: 7139
• Length: 505
• Species: Homo sapiens
• Sequence 2: NP_650330.3
• Gene: foxo / 41709
• FlyBaseID: FBgn0038197
• Length: 622
• Species: Drosophila melanogaster
• Alignment Length: 562
• Identity: 191/562 - (33%)
• Similarity: 249/562 - (44%)
• Gaps: 162/562 - (28%)

Human    16 IDLDPDFEPQSRPRSCTWPLPRPEIANQPSEPPEVEPDLGEKVHTEGRSEPILLPSRLPEPAGGP 80
            :.||..||||:|.||.|||.||||...:|:          :::.:...|...|.|       |..
  Fly    28 LPLDVGFEPQTRARSNTWPCPRPENFVEPT----------DELDSTKASNQQLAP-------GDS 75

Human    81 QPGILGAVTGPRKGGSRRNAWGNQSYAELISQAIESAPEKRLTLAQIYEWMVRTVPYFKDKGDSN 145
            |..|..| ...:|..||||||||.|||:||:.||.||.:|||||:|||||||:.|||||||||||
  Fly    76 QQAIQNA-NAAKKNSSRRNAWGNLSYADLITHAIGSATDKRLTLSQIYEWMVQNVPYFKDKGDSN 139

Human   146 SSAGWKNSIRHNLSLHSKFIKVHNEATGKSSWWMLNPEGGKSGKAPRRRAASMDSSSKLLRGRSK 210
            ||||||||||||||||::|::|.||.|||||||||||| .|.||:.|||||||: :|:..:.|.:
  Fly   140 SSAGWKNSIRHNLSLHNRFMRVQNEGTGKSSWWMLNPE-AKPGKSVRRRAASME-TSRYEKRRGR 202

Human   211 APKKKPSVLPAPPEGATPTSPVGHFAKWSGSPCSRNREEAD--------------MWTTFRPRSS 261
            |.|:..::..|...|....:|         ||.|...|..|              :...||.|:|
  Fly   203 AKKRVEALRQAGVVGLNDATP---------SPSSSVSEGLDHFPESPLHSGGGFQLSPDFRQRAS 258

Human   262 SNASSVSTRLSPLRPESEVLAEEIPASVSSYAGGVPPTLNEGLELLDGLN--LTSSHSLLSRSGL 324
            |||||.. ||||:|      |:::...     .|.|         :|..|  :|.:|:.
  Fly   259 SNASSCG-RLSPIR------AQDLEPD-----WGFP---------VDYQNTTMTQAHAQ------ 296

Human   325 SGFSLQHPGVTGPLHTYSSSLFSPAEGPLSAGEGCFSSSQALEALLTSDTPPPP--------ADV 381
               :|:.  :||.: ....:|.:..:...||..|           |.|..||||        |..
  Fly   297 ---ALEE--LTGTM-ADELTLCNQQQQGFSAASG-----------LPSQPPPPPYQPPQHQQAQQ 344

Human   382 LMTQVDPILSQAP-----TL------LLLGGLPSSSKLATGVGLCPKPLEAPGPSSLVPTLSMIA 435
            ...|..|.....|     ||      ||...|..|.......||        .|:|:..|:|
  Fly   345 QQQQQSPYALNGPASGYNTLQPQSQCLLHRSLNCSCMHNARDGL--------SPNSVTTTMS--- 398

Human   436 PPPVMASAPIPKALGT---PVLTPPTEAAS-----QDRMPQDLDLDMYME--------------- 477
             |....|.|...:|.|   .||..|.:.|:     |.:..|...|...:|
  Fly   399 -PAYPNSEPSSDSLNTYSNVVLDGPADTAALMVQQQQQQQQQQQLSASLEDNNCASTLIGQCLEV 462

Human   478 -------------------NLECDMDNIISDLMDEGEGLDFN 500
                               ||||:::.::...|..|..||.|
  Fly   463 LNNEAQPIDEFNLENFPVGNLECNVEELLQQEMSYGGLLDIN 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FOXO4	NP_005929.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..100		28/83 (34%)
		FH_FOXO4	98..183	CDD:410836	68/84 (81%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	176..246		28/69 (41%)
		FOXO_KIX_bdg	<358..393	CDD:465228	10/42 (24%)
		FOXO-TAD	465..503	CDD:435506	12/70 (17%)
foxo	NP_650330.3	FH_FOXO	96..175	CDD:410806	62/78 (79%)