Protein Alignment FOXO4 and fhl1

DIOPT Version :10

• Sequence 1: NP_005929.2
• Gene: FOXO4 / 4303
• HGNCID: 7139
• Length: 505
• Species: Homo sapiens
• Sequence 2: NP_594272.1
• Gene: fhl1 / 2541552
• PomBaseID: SPAC1142.08
• Length: 743
• Species: Schizosaccharomyces pombe
• Alignment Length: 506
• Identity: 119/506 - (23%)
• Similarity: 183/506 - (36%)
• Gaps: 147/506 - (29%)

Human    13 AAIIDLDPDFEPQSRPRSCTWPL------PRPEIANQPSEPPEVEPDLGEKVHTEGRSEPILLPS 71
            ::|..|.|  :|..||.|...|:      ..|::||...|            ..:|:|..   ||
pombe   224 SSIQRLSP--QPYVRPTSDERPIETDSSVSAPKVANHDEE------------LKQGKSTS---PS 271

Human    72 RL---PEPAGGPQPGILGAVTGPRKGGSRRNAWGNQSYAELISQAIESAPEKRLTLAQIYEWMVR 133
            ..   |:..|.|..|  .|...|           |.|||.||::.:.:.|.|::||..|.||:..
pombe   272 DTVLHPDLNGSPDTG--DATQKP-----------NLSYANLIARTLIANPNKKMTLGDICEWIAN 323

Human   134 TVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIKV---HNEATGKSSWWMLNPEGGKSGKAPRRRA 195
            ...|::     :....|.|||||||||:..||::   .|| .||.|:|||:|
pombe   324 NWSYYR-----HQPPAWHNSIRHNLSLNKAFIRIPRRQNE-PGKGSFWMLDP------------- 369

Human   196 ASMDSSSKLLRGRSKAPKKKPSVLPAPPEGATPTSPVGHFAKWSGSPCSRNREEADMWT------ 254
            :.:|........|:|.|  .||..||    |.|.:             :|..|.|.:.|
pombe   370 SYIDQFEGNFFRRTKKP--TPSATPA----AHPDT-------------ARENELAAIQTKGISAG 415

Human   255 ---TFRPRSSSNASSVSTRLSPLRPESEVLAEEIPASVSSYAGGVPPTLNEGLELLDG------- 309
               ...|:..::.|...|.    |.|:   .|:.|.|:  ...|:.|.:     :.||
pombe   416 KTEQLNPQKETSRSKTHTS----RGEN---VEDRPQSL--LQNGIQPII-----MRDGKLALNPE 466

Human   310 --LNLTSSHSLLSRSGLSGFSLQHPGVTGPLHTYSSSLFSPAEGPLSAGEGCFSSSQALEALLTS 372
              .|........:...:...||....:...|...:::  :|.:....|.....:.:|.|:...|.
pombe   467 FFKNANGEQQAPNEQAVQAISLLQQHINKQLGPAAAN--NPEQATAIANALAVALAQKLQKQQTQ 529

Human   373 DTPPPPADVLMTQVDPILSQ----APTLLLLGGLPSSSKLATGVGLCPKP-LEAPGPSSLV---P 429
            ...|........:.....||    |||.:                  |.| :.:|.||..|   |
pombe   530 MQGPQQVQQQAKRRKAYTSQQLNPAPTAM------------------PHPNITSPSPSISVTQRP 576

Human   430 TLSMIAPPPVMASAP--IP---KALGTPVLTPPTEAASQDRMPQDLDLDMY 475
            .:::..||.|..|||  :|   :::|.|:  ||...|:....|..:....|
pombe   577 AVNVGPPPYVRPSAPSKLPDTRQSIGDPL--PPGAMANVSAGPSSVRSSSY 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FOXO4	NP_005929.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..100		22/95 (23%)
		FH_FOXO4	98..183	CDD:410836	34/87 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	176..246		15/69 (22%)
		FOXO_KIX_bdg	<358..393	CDD:465228	6/38 (16%)
		FOXO-TAD	465..503	CDD:435506	2/11 (18%)
fhl1	NP_594272.1	COG5025	1..564	CDD:227358	100/441 (23%)