DRSC/TRiP Functional Genomics Resources

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Protein Alignment FOXO4 and sep1

DIOPT Version :10

Sequence 1:NP_005929.2 Gene:FOXO4 / 4303 HGNCID:7139 Length:505 Species:Homo sapiens
Sequence 2:NP_596301.1 Gene:sep1 / 2540866 PomBaseID:SPBC4C3.12 Length:663 Species:Schizosaccharomyces pombe


Alignment Length:478 Identity:113/478 - (23%)
Similarity:166/478 - (34%) Gaps:184/478 - (38%)


- Green bases have known domain annotations that are detailed below.


Human    34 PLPRPEIANQPSEPPEVEPDLGEKVHTEGRSEPILLPSRLPEPA-------GGPQPGILGAVTGP 91
            |||.|    .|||         :.:.|.....|.:..|:..||.       .|.:|         
pombe    87 PLPIP----PPSE---------QSLDTIIYRNPSVSSSQSQEPEEFFLPLDDGKKP--------- 129

Human    92 RKGGSRRNAWGNQSYAELISQAIESAPEKRLTLAQIYEWMVRTVPYFKDKGDSNSSAGWKNSIRH 156
                       ..|||.||..:|..:|::||||:.||:|:..|..::     :.|:.||:|||||
pombe   130 -----------PYSYAMLIGMSIIRSPDRRLTLSAIYDWISNTFSFY-----NKSNNGWQNSIRH 178

Human   157 NLSLHSKFIKVH--NEATGKSSWWMLNPEGGKSGKAPRRRAASMDSSSKLLRGRSKAPKKKPSV- 218
            ||||:..|:|:.  ....||..:|.:.|                ....:.|    |...:||.| 
pombe   179 NLSLNKAFMKIERPRNLPGKGHFWSIRP----------------GHEEQFL----KLKLRKPGVN 223

Human   219 -LPAPP-EGATPTSPVGHFAKWSGSPCSRNREEADMWTTFRPRSSSNASSVST-RLSP--LRPES 278
             .|||| :..|.::..|                          ||:.:|..:| ..||  .....
pombe   224 SRPAPPVQDVTSSTKYG--------------------------SSTGSSGFNTFNTSPHIFNQRH 262

Human   279 EVLAEEIPASVSSYAGGVPPTLNEGLELLDGLNLTSSHSLLSRSGLSGFSLQHPG---------- 333
            :.|.....||:::.     ||::       .:|.|:.|.|.|:...    :..||          
pombe   263 QYLQNYYTASLTNI-----PTIS-------NVNATNFHPLHSQQPY----VDTPGIDAPSDLEAK 311

Human   334 -----------VTGPLHTYSSSLFSPAEGPLSAGEGCFSSSQAL--EAL---------LTSDTPP 376
                       ||.||.:.::|...|...|.|:.    |.|::|  |:|         |..|..|
pombe   312 FSDLGVSSVVSVTSPLQSCTNSPSPPLSSPASSA----SPSESLRNESLGIKSAKSLGLNKDDAP 372

Human   377 ---PPADVLMTQV------DPILSQAPTLLLLG--------------------GLPSSSKLATGV 412
               ||...|...|      |.:|....|:..||                    .||||..:....
pombe   373 VEGPPVSHLEKDVETPSVHDSVLGFNDTVTNLGKKGLKDGTTNTLQIPAVRLPSLPSSPTIKNPS 437

Human   413 GLCPK---PLEAP-GPSSLVPTL 431
            ||..|   .::.| .|.:|.|.|
pombe   438 GLLLKRSNSIDFPTPPKALCPKL 460

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FOXO4NP_005929.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..100 14/72 (19%)
FH_FOXO4 98..183 CDD:410836 32/86 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 176..246 13/72 (18%)
FOXO_KIX_bdg <358..393 CDD:465228 14/54 (26%)
FOXO-TAD 465..503 CDD:435506
sep1NP_596301.1 COG5025 20..663 CDD:227358 113/478 (24%)
Blue background indicates that the domain is not in the aligned region.

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