DRSC/TRiP Functional Genomics Resources

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Protein Alignment FOXO4 and mei4

DIOPT Version :10

Sequence 1:NP_005929.2 Gene:FOXO4 / 4303 HGNCID:7139 Length:505 Species:Homo sapiens
Sequence 2:NP_595617.1 Gene:mei4 / 2540241 PomBaseID:SPBC32H8.11 Length:517 Species:Schizosaccharomyces pombe


Alignment Length:464 Identity:119/464 - (25%)
Similarity:175/464 - (37%) Gaps:122/464 - (26%)


- Green bases have known domain annotations that are detailed below.


Human   105 SYAELISQAIESAPEKRLTLAQIYEWMVRTVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIKVHN 169
            |||.||..||..:..|:|||:.||.|:..|..|:     .|...||:|||||||||:..||||..
pombe    85 SYATLIGLAILQSHNKQLTLSGIYTWIRNTFRYY-----LNHDGGWQNSIRHNLSLNKAFIKVEK 144

Human   170 E--ATGKSSWWMLNPEGGKSGKAPR-RRAASMDSSSKLLRGRSKAPKKKPSVLPAPPEGATPTSP 231
            .  .|.|..:|.::|:..::..:.| .|:.|.||:|| .|..||..:.||......|. |...|.
pombe   145 PKGKTLKGHYWTIDPDHMQNFVSVRLHRSHSTDSNSK-KRPSSKCHEIKPLTTREIPL-ARKRSR 207

Human   232 VGHFAKWSGSPCSRNREEADMWTTFRPRSSSNASSVSTRLSPLRPESEVLAEEIPASVSSYAGGV 296
            :..|...:.:..|.:...|::.......|:.::|..|..:.|..|.|.|      .|.||.:..|
pombe   208 LNSFNSSTSTSGSSSNVAAEVSNDASQPSNQDSSLNSNIVKPPLPPSNV------QSNSSSSENV 266

Human   297 P----------PTLN-EGLELLDGLNLTSSHSLLSRSGL---SGFSLQHPGVTGPLHTYSSSLF- 346
            |          ||:: ....|.:.:|.:..:.:.:...:   :|:|...||       |..:.| 
pombe   267 PKPNAETQEDLPTIDAHESSLYENVNDSRLYEVPACRNMALNTGYSDADPG-------YLRTSFR 324

Human   347 --SPAEGPLSAGEGCFSSSQALEALLTSDTPPPPADVLMTQVDPILSQ----------------- 392
              |....|.||.|    ....|:           ||.|::|...::|.                 
pombe   325 SNSHNSLPYSANE----EEDVLQ-----------ADFLVSQQSSMVSSYVSSRDPHSMPYYRREP 374

Human   393 -------------APTLLLLGGLPSSSKLATGVGLCPKPLEAP---------GPSSLVPTLSMIA 435
                         .||.    |...:|..|.| ..|...:.:|         .|||  ||||:  
pombe   375 IPLRPSSRFYEYTRPTY----GRTDTSCSAPG-AFCSTQINSPSSYINYSKCAPSS--PTLSL-- 430

Human   436 PPPVMASAPIPKALGTPVLTP------PTEAASQ-------DRMPQDLDLDMYMENLECDMDNII 487
               ......:...|..|.|||      |...:||       |:......||..| ::.|..|:  
pombe   431 ---QKHREHVKSLLYVPDLTPSFDGSDPWNPSSQLLSEPLFDQHSFQSSLDDLM-SVTCFRDS-- 489

Human   488 SDLMDEGEG 496
            .:|..|..|
pombe   490 PELNHESSG 498

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FOXO4NP_005929.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..100
FH_FOXO4 98..183 CDD:410836 35/79 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 176..246 19/70 (27%)
FOXO_KIX_bdg <358..393 CDD:465228 6/64 (9%)
FOXO-TAD 465..503 CDD:435506 8/32 (25%)
mei4NP_595617.1 COG5025 1..517 CDD:227358 119/464 (26%)
Blue background indicates that the domain is not in the aligned region.

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