DRSC/TRiP Functional Genomics Resources

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Protein Alignment FOXO4 and daf-16

DIOPT Version :10

Sequence 1:NP_005929.2 Gene:FOXO4 / 4303 HGNCID:7139 Length:505 Species:Homo sapiens
Sequence 2:NP_001367893.1 Gene:daf-16 / 172981 WormBaseID:WBGene00000912 Length:541 Species:Caenorhabditis elegans


Alignment Length:420 Identity:145/420 - (34%)
Similarity:211/420 - (50%) Gaps:107/420 - (25%)


- Green bases have known domain annotations that are detailed below.


Human    58 VHTE--GRSEPILLPS--RLPEPAGGPQPGILGAVTGPRKGGSRRNAWGNQSYAELISQAIESAP 118
            :||.  ..|.....||  |:.|   .|...:.|     :|..:|||||||.||||||:.||.::|
 Worm   136 LHTPDGSNSHQTSFPSDFRMSE---SPDDTVSG-----KKTTTRRNAWGNMSYAELITTAIMASP 192

Human   119 EKRLTLAQIYEWMVRTVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIKVHNEATGKSSWWMLNPE 183
            ||||||||:|||||:.||||:|||||||||||||||||||||||:|:::.||..||||||::||:
 Worm   193 EKRLTLAQVYEWMVQNVPYFRDKGDSNSSAGWKNSIRHNLSLHSRFMRIQNEGAGKSSWWVINPD 257

Human   184 GGKSGKAPRR---RAASMDSSSKL-----LRGRSKAPKKKPSVLPAPPEGATPTSPVGHFAKWSG 240
             .|.|:.|||   |:.::::::|.     .||..|..|::..:      |:..::..|:....|.
 Worm   258 -AKPGRNPRRTRERSNTIETTTKAQLEKSRRGAKKRIKERALM------GSLHSTLNGNSIAGSI 315

Human   241 SPCSRNREEADMW--------TTFRPRSSSNAS--SVSTRLSP-----LRPESEV---LAEEIPA 287
            ...|.:..:.|..        ::||||:.||.|  ..|:|:||     :..:.|.   :.|.:||
 Worm   316 QTISHDLYDDDSMQGAFDNVPSSFRPRTQSNLSIPGSSSRVSPAIGSDIYDDLEFPSWVGESVPA 380

Human   288 --------------SVSSYAGGV----------------PPTLNEGLELLDGLNLTSSHSLLSRS 322
                          ..:::.|||                ||:.:|    |:.:..:.:.:.|.|:
 Worm   381 IPSDIVDRTDQMRIDATTHIGGVQIKQESKPIKTEPIAPPPSYHE----LNSVRGSCAQNPLLRN 441

Human   323 --------------GLSGFSLQHPGVTGPLHTYSSSLFSPAEGPLSAG----EGCFSSSQALEAL 369
                          |..| :.|:.|:| |::..|:|..||..|..|.|    :...:||.||...
 Worm   442 PIVPSTNFKPMPLPGAYG-NYQNGGIT-PINWLSTSNSSPLPGIQSCGIVAAQHTVASSSALPID 504

Human   370 LTSDTPP--PPADVLMTQVDPI----LSQA 393
            |.:.|.|  |..|.:  .||.:    ||||
 Worm   505 LENLTLPDQPLMDTM--DVDALIRHELSQA 532

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FOXO4NP_005929.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..100 12/45 (27%)
FH_FOXO4 98..183 CDD:410836 65/84 (77%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 176..246 20/77 (26%)
FOXO_KIX_bdg <358..393 CDD:465228 13/40 (33%)
FOXO-TAD 465..503 CDD:435506
daf-16NP_001367893.1 FH_FOXO 176..255 CDD:410806 60/78 (77%)
Blue background indicates that the domain is not in the aligned region.

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