Protein Alignment FOXO4 and foxo4

DIOPT Version :10

• Sequence 1: NP_005929.2
• Gene: FOXO4 / 4303
• HGNCID: 7139
• Length: 505
• Species: Homo sapiens
• Sequence 2: XP_002934931.1
• Gene: foxo4 / 100492831
• XenbaseID: XB-GENE-480655
• Length: 492
• Species: Xenopus tropicalis
• Alignment Length: 501
• Identity: 274/501 - (54%)
• Similarity: 336/501 - (67%)
• Gaps: 51/501 - (10%)

Human    16 IDLDPDFEPQSRPRSCTWPLPRPEIANQPSEPPEVEPDLGEKVHTEGRSEPILLPSRLPEPAGGP 80
            :::||||:||:|.|||||||||||::   ..||...   .|:..|:....|.|||:...:.:.|.
 Frog     9 VEIDPDFQPQTRQRSCTWPLPRPELS---VVPPAAS---SEESRTDTPDGPSLLPAEGEDRSLGD 67

Human    81 QPGILGAVTGPRKGGSRRNAWGNQSYAELISQAIESAPEKRLTLAQIYEWMVRTVPYFKDKGDSN 145
            .|...|.|| ||||||||||||||||||||||||||:|||||||:|||:|||:::||||||||||
 Frog    68 GPVGGGGVT-PRKGGSRRNAWGNQSYAELISQAIESSPEKRLTLSQIYDWMVKSIPYFKDKGDSN 131

Human   146 SSAGWKNSIRHNLSLHSKFIKVHNEATGKSSWWMLNPEGGKSGKAPRRRAASMDSSSKLLRGRSK 210
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||.:.|:|
 Frog   132 SSAGWKNSIRHNLSLHSKFIKVHNEATGKSSWWMLNPEGGKSGKAPRRRAASMDNSSKLAKVRNK 196

Human   211 APKKKPSVLPAPPEGATPTSPVGHFAKWSGSPCSRNREEADMWTTFRPRSSSNASSVSTRLSPLR 275
            ..|||.:....|..|:..:.|    .||.|||.||:.||:|:||:||||:.||||::|.||||:.
 Frog   197 VSKKKAAGPGEPSAGSPGSQP----PKWPGSPSSRSAEESDVWTSFRPRTGSNASNLSVRLSPIL 257

Human   276 PESEVLAEEIPASVSSYAGGVPPTLNEGLELLDGLNLTSSHSLLSR-----SGLSGFSLQHPGVT 335
            ||.|.||:|...|: |::..||||:.|.|||:|||.:.||...|..     .|.|.|||.    :
 Frog   258 PEQEDLADEELHSI-SFSNSVPPTVTEELELIDGLTMLSSGPPLPAPQPLLQGASSFSLH----S 317

Human   336 GPLHTYSSSLFSPAE-GPLSAGEGCFSSSQALEALLTSDTPPPPADVLMTQVDPILSQA--PTLL 397
            .....:.:|||||.: .|:......|...|.||||||||: |||::||||||||:|.|:  .:||
 Frog   318 SQAINFGNSLFSPLDVSPVQGSSTQFQRPQTLEALLTSDS-PPPSNVLMTQVDPVLPQSGGQSLL 381

Human   398 LLGGLPSSSKLATGVGLCP-KP---LEAPGPSSLVPTLSMIAPPPVMASAPIPKALGTPVLTPPT 458
            .:|        |...|..| ||   |.....|:.:..|.:.:.|.|..|...|  ||
 Frog   382 HMG--------AQNKGRTPDKPAVSLNTVVTSNKLTMLGLPSVPSVSTSKSGP--LG-------- 428

Human   459 EAASQDRMPQDLDLDMYMENLECDMDNII-SDLMDEGEGLDFNFEP 503
              .:.||:|.|||:||.:|||||||:.|| ::||||| ||||||||
 Frog   429 --GTSDRLPIDLDIDMILENLECDMEYIINNELMDEG-GLDFNFEP 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FOXO4	NP_005929.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..100		39/83 (47%)
		FH_FOXO4	98..183	CDD:410836	78/84 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	176..246		42/69 (61%)
		FOXO_KIX_bdg	<358..393	CDD:465228	22/34 (65%)
		FOXO-TAD	465..503	CDD:435506	27/38 (71%)
foxo4	XP_002934931.1	FH_FOXO4	84..169	CDD:410836	78/84 (93%)
		FOXO_KIX_bdg	323..387	CDD:465228	33/72 (46%)
		FOXO-TAD	433..472	CDD:435506	29/40 (73%)