DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Ca and Tie1

DIOPT Version :9

Sequence 1:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	NP_445997.1	Gene:	Tie1 / 89806	RGDID:	621642	Length:	1137	Species:	Rattus norvegicus

Alignment Length:	791	Identity:	206/791 - (26%)
Similarity:	318/791 - (40%)	Gaps:	256/791 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 DPDGDDLIFGIEPR--------FSLP--GGENDASP--------PEKI------------PFQID 117
            ||..:..:..::||        .|.|  |||....|        ||.:            |   |
  Rat   500 DPSENVTLMNLKPRTGYNVRVQLSRPGEGGEGAWGPSTLMTTDCPEPLLQPWVESWNVEGP---D 561

  Fly   118 RETGVVTLNESLAG--RAGQNFLIYITVTDGSYTAKNEVFINILGERENSSGYRPQTSISNVVHN 180
            |    :.::.||..  .:|..||  :.:.||:...:         .|||.|..:.:|::
  Rat   562 R----LRVSWSLPSVPLSGDGFL--LRLWDGARGQE---------RRENISSPQARTAL------ 605

  Fly   181 ISQFLPRFDQLPGVQSIRNGLPNSRPGGWY-------------PPVPQNNIF----GPPPFGN-- 226
                                |....||..|             |..|..::.    |||...:
  Rat   606 --------------------LTGLTPGTHYQLDVRLYHCTLLGPASPSAHVHLPLSGPPAPRHLR 650

  Fly   227 -------------NYPPPPP----------NIPGVRGE-QSGEEEQPDEEVTPTTPVRISSTTPK 267
                         .:|..||          .:.|..|: |..:.::|:|          :|||.:
  Rat   651 AQALSDSEIRLMWQHPEAPPGPISKYIVEIQVAGGSGDPQWMDVDKPEE----------TSTTVR 705

  Fly   268 SRTKLTPITANNST----RVESAIPA---------ETTTPSGGHHNNSSSPITIFSLKSGTI--P 317
            .        .|.||    ||.:::..         |||.   |:...|:||:....:....:  .
  Rat   706 G--------LNASTRYLFRVRASVQGLGDWSNTVEETTL---GNGLQSASPVQESRVAEDGLDQQ 759

  Fly   318 IVVTVGGFFVA-----IAVLLAYLCRRRLCAISR---TLKKTKEKEELAKKSNQSQLSSTLTDDS 374
            :|:.|.|...|     :|.|||.:|.||.|...|   |.:....:|.:.:.|     |.|||...
  Rat   760 LVLAVVGSVSATCLTILAALLALVCIRRSCLHRRHTFTYQSGSGEETILQFS-----SGTLTLTR 819

  Fly   375 RNSMVMQQWQGPVAFANRYVPWERDQQMGIATSQLSTGVTNGGVSSPGVPSPGTGEPGSNLGPGC 439
            |.....:....||      :.||
  Rat   820 RPKPQPEPLSYPV------LEWE------------------------------------------ 836

  Fly   440 LTGGAGSSGAPENAFAGEANCDRWEFPRYRLKFFNILGEGAFGQVWRCEATNINGNEGI-TTVAV 503
                                         .:.|.:::|||.||||.|.    :...:|: ...|:
  Rat   837 -----------------------------DITFEDLIGEGNFGQVIRA----MIKKDGLKMNAAI 868

  Fly   504 KTLKESATEVDRKDLLSELEVMKSLEPHINVVHLLGCCTDKDPTFVILEYVNRGKLQTYLRSSR- 567
            |.|||.|:|.|.:|...||||:..|..|.|:::|||.|.::...::.:||...|.|..:||.||
  Rat   869 KMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACENRGYLYIAIEYAPYGNLLDFLRKSRV 933

  Fly   568 --AERHYGNTHGKSNVLTSCDLTSFMYQVAKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFG 630
              .:..:...||.::.|:|..|..|....|.||.||:.:..|||||||||:|:.::...|:||||
  Rat   934 LETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFG 998

  Fly   631 FARDVITSKIYERKSEGKLPIRWMATESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISAAD 695
            .:|.   .::|.:|:.|:||:||||.|||..::::.|||:||||:|:||||:||.|||.|::.|:
  Rat   999 LSRG---EEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAE 1060

  Fly   696 VMRKVRDGYRLEKPEHCRRELYNIMYYCWSHDPQERPLFAEIIQMLDKLLHTEMDYIELERFPDH 760
            :..|:..|||:|:|.:|..|:|.:|..||...|.|||.||:|...|.::|.....|:.:..|.:.
  Rat  1061 LYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFENF 1125

  Fly   761 NYYNIVSLSGE 771
            .|..|.:.:.|
  Rat  1126 TYAGIDATAEE 1136

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637	23/112 (21%)
		STYKc	470..741	CDD:214568	115/274 (42%)
		PTKc	474..742	CDD:270623	114/271 (42%)
Tie1	NP_445997.1	ig	130..211	CDD:278476
		EGF_Lam	228..266	CDD:238012
		EGF_CA	315..346	CDD:238011
		ig	357..442	CDD:278476
		IG_like	370..444	CDD:214653
		fn3	450..530	CDD:278470	7/29 (24%)
		fn3	549..631	CDD:278470	20/125 (16%)
		FN3	643..735	CDD:238020	19/109 (17%)
		PTKc_Tie1	835..1131	CDD:270671	122/373 (33%)
		TyrKc	838..1106	CDD:197581	115/274 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006344
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910