DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad96Ca and Tek

DIOPT Version :9

Sequence 1:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	NP_001099207.1	Gene:	Tek / 89804	RGDID:	620980	Length:	1120	Species:	Rattus norvegicus

Alignment Length:	863	Identity:	221/863 - (25%)
Similarity:	335/863 - (38%)	Gaps:	254/863 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 EAHNQNAPPILYVRERNWRISETEKVGQIIDRVRAEDPDGDDLIFGIEPRFSLPGGENDASPPEK 111
            |.::....||  .:...|.:..:|::..:       .|||..|    :|        ||.:..:.
  Rat   360 EVNSGKFNPI--CKASGWPLPTSEEMTLV-------KPDGTVL----QP--------NDFNHTDH 403

  Fly   112 IP---FQIDR----ETGV-VTLNESLAGRAGQNFLIYITVTDGSYTAKNEV-------FINILGE 161
            ..   |.::|    ::|| |....::||...:.|.|.:.|......|.|.:       .|||..|
  Rat   404 FSVAIFTVNRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPEPLHAPNVIDTGHNFAIINISSE 468

  Fly   162 RENSSG--------YRP------QTSISNVVHNISQFLPRFDQLPGVQSIRNGLPNSRPGGWYPP 212
            .....|        |:|      ...:.|.:..::...||.|....||.:|.|     .||...|
  Rat   469 PYFGDGPIKSKKLFYKPVNQAWKYIQVMNEIVTLNYLEPRTDYELCVQLVRPG-----EGGEGHP 528

  Fly   213 VPQN-----NIFGPPPFGNNYPPP----------------------------------------P 232
            .|..     :|..|||.|.:..|.                                        |
  Rat   529 GPVRRFTTASIGLPPPRGLSLLPKSQTALNLTWQPIFTSSEDEFYVEVERWSQQTRSDQQNIKVP 593

  Fly   233 PNIPGV---------------RGEQSGEEEQPDE-------EVTPTTPVRISSTTPKSRTKLTPI 275
            .|:..|               |.....:.|..:|       ::.|..|..|..|.....|.|...
  Rat   594 GNLTSVLLNNLLPREQYSVRARVNTKAQGEWSEELRAWTLSDILPPQPENIKITNITDYTALVSW 658

  Fly   276 T------------------ANNSTRVESAIPAETTT--------PSGGHH------NNSSSPITI 308
            |                  .|....::..|...|.|        |...:|      ||..|....
  Rat   659 TIVDGYSISSIIIRYKVQGKNEDQHIDVKIKNATITQYQLKGLEPETTYHVDIFAENNIGSSNPA 723

  Fly   309 FSLKSGTIPIVVTVGG---FFVA---------IAVLLAYLCRRRLCAISRTLKKTKEKEELAKKS 361
            ||.:..|:|....:||   ..:|         |.||||:|       |...||:...:..:|:
  Rat   724 FSQEIRTLPAPKDLGGGKMLLIAILGSAGMTCITVLLAFL-------IMLQLKRANVQRRMAQ-- 779

  Fly   362 NQSQLSSTLTDDSRNSMVMQQWQGPVAFANRYVPWERDQQMGIATSQLSTGVTNGGVSSPGVPSP 426
                                      ||.|  |..|...|....|..|:....|.       |.|
  Rat   780 --------------------------AFQN--VREEPAVQFNSGTLALNRKAKNN-------PDP 809

  Fly   427 GTGEPGSNLGPGCLTGGAGSSGAPENAFAGEANCDRWEFPRYRLKFFNILGEGAFGQVWRCEATN 491
             |..|..:                            |.    .:||.:::|||.||||.:....
  Rat   810 -TIYPVLD----------------------------WN----DIKFQDVIGEGNFGQVLKARIK- 840

  Fly   492 INGNEGI-TTVAVKTLKESATEVDRKDLLSELEVMKSLEPHINVVHLLGCCTDKDPTFVILEYVN 555
               .:|: ...|:|.:||.|::.|.:|...||||:..|..|.|:::|||.|..:...::.:||..
  Rat   841 ---KDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAP 902

  Fly   556 RGKLQTYLRSSR---AERHYGNTHGKSNVLTSCDLTSFMYQVAKGMDYLTSRGIIHRDLAARNIL 617
            .|.|..:||.||   .:..:...:..::.|:|..|..|...||:|||||:.:..|||||||||||
  Rat   903 HGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNIL 967

  Fly   618 ITDDHTCKVADFGFARDVITSKIYERKSEGKLPIRWMATESLYDNIFSVKSDIWSFGILMWEIVT 682
            :.:::..|:||||.:|.   .::|.:|:.|:||:||||.|||..::::..||:||:|:|:||||:
  Rat   968 VGENYIAKIADFGLSRG---QEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVS 1029

  Fly   683 LGSTPYPGISAADVMRKVRDGYRLEKPEHCRRELYNIMYYCWSHDPQERPLFAEIIQMLDKLLHT 747
            ||.|||.|::.|::..|:..|||||||.:|..|:|::|..||...|.|||.||:|:..|:::|..
  Rat  1030 LGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEE 1094

  Fly   748 EMDYIELERFPDHNYYNI 765
            ...|:....:....|..|
  Rat  1095 RKTYVNTTLYEKFTYAGI 1112

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637	24/113 (21%)
		STYKc	470..741	CDD:214568	114/274 (42%)
		PTKc	474..742	CDD:270623	112/271 (41%)
Tek	NP_001099207.1	Ig_Tie2_1	24..118	CDD:287411
		EGF_Lam	230..275	CDD:238012
		fn3	445..518	CDD:278470	15/72 (21%)
		fn3	542..625	CDD:278470	10/82 (12%)
		FN3	638..730	CDD:238020	18/91 (20%)
		PTKc_Tie2	812..1114	CDD:133219	121/340 (36%)
		STYKc	820..1088	CDD:214568	114/274 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910