DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad96Ca and Fgfr3

DIOPT Version :9

Sequence 1:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	XP_006251452.1	Gene:	Fgfr3 / 84489	RGDID:	620714	Length:	804	Species:	Rattus norvegicus

Alignment Length:	855	Identity:	233/855 - (27%)
Similarity:	361/855 - (42%)	Gaps:	231/855 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 IIVVTATVVSLISQEAEAHNQNAPPILYVRERNWRISETEKVGQIIDRVRAEDPDGDDLI-FG-- 92
            ::|....||:.::.|        ||           ...::||:....|...:|...:.: ||
  Rat     7 VLVFCVAVVAGVTSE--------PP-----------GPEQRVGRRAAEVPGPEPSQQEQVAFGSG 52

  Fly    93 --IEPRFSLPGGENDASP-------------------PEKIPFQI----DRETGVVTLNESLAGR 132
              :|.....|||. ...|                   |:::  |:    ..:.||.:..:.|..|
  Rat    53 DTVELSCHPPGGA-PTGPTLWAKDGVGLVASHRILVGPQRL--QVLNATHEDAGVYSCQQRLTRR 114

  Fly   133 AGQNFLIYITVTDGSYTAKNEVFINILGE---RENSSGY--RPQTSISNVVHNISQFLPRFDQ-- 190
            ...:|  .:.|||...:..:|.     ||   .:..:.|  ||:               |.|:
  Rat   115 VLCHF--SVRVTDAPSSGDDED-----GEDVAEDTGAPYWTRPE---------------RMDKKL 157

  Fly   191 --LPGVQSIRNGLPNSRPGGWYPPVPQNNIFGPPPFGNNYPPPPPNIPGVRGEQSGEEEQPDEEV 253
              :|...::|                    |..|..||    |.|:|..::   :|:|.:.:..:
  Rat   158 LAVPAANTVR--------------------FRCPAAGN----PTPSISWLK---NGKEFRGEHRI 195

  Fly   254 ------TPTTPVRISSTTPKSRTKLTPITAN--NSTR----------------VESAIPAETTTP 294
                  .....:.:.|..|..|...|.:..|  .|.|                :::.:||..|..
  Rat   196 GGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAV 260

  Fly   295 SGGHHNNSSSPITIFSLK--SGTIPIV-----VTVGGFFVA------IAVLLAYL-------CRR 339
            .|..        ..|..|  |...|.:     |.|.|..|.      :.||.:::       .|.
  Rat   261 LGSD--------VEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISENVEADARL 317

  Fly   340 RLCAISRTLKKTKEKEELAKKSNQSQLSSTLTDDSRNSMVMQQW---QGPVAFANRYVPWERDQQ 401
            ||..:|    :....|.|.:.:|...::....           |   .||.|.....:  |.|:.
  Rat   318 RLANVS----ERDGGEYLCRATNFIGVAEKAF-----------WLRVHGPQAAEEELM--EVDEA 365

  Fly   402 MGIATSQLSTG------------VTNGGVSSPGVPSPGTGEP--------------------GSN 434
            ..:....||.|            ||...:.||  |..|.|.|                    .|:
  Rat   366 GSVYAGVLSYGVGFFLFILVVAAVTLCRLRSP--PKKGLGSPTVHKVSRFPLKRQVTVSLESNSS 428

  Fly   435 LGPGC-------LTGGAGSSGAPENAFAGEANCD-RWEFPRYRLKFFNILGEGAFGQVWRCEATN 491
            :....       |:.|.|...|  |....|...| :||..|.||.....||||.||||...||..
  Rat   429 MNSNTPLVRIARLSSGEGPVLA--NVSELELPADPKWELSRTRLTLGKPLGEGCFGQVVMAEAIG 491

  Fly   492 INGNEGI--TTVAVKTLKESATEVDRKDLLSELEVMKSLEPHINVVHLLGCCTDKDPTFVILEYV 554
            |:.:...  .|||||.||:.||:.|..||:||:|:||.:..|.|:::|||.||...|.:|::||.
  Rat   492 IDKDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYA 556

  Fly   555 NRGKLQTYLRSSR---AERHYGNTHGKSNVLTSCDLTSFMYQVAKGMDYLTSRGIIHRDLAARNI 616
            .:|.|:.:||:.|   .:..:.........||..||.|..||||:||:||.|:..|||||||||:
  Rat   557 AKGNLREFLRARRPPGMDYSFDACRLPEEQLTCKDLVSCAYQVARGMEYLASQKCIHRDLAARNV 621

  Fly   617 LITDDHTCKVADFGFARDVITSKIYERKSEGKLPIRWMATESLYDNIFSVKSDIWSFGILMWEIV 681
            |:|:|:..|:||||.||||.....|::.:.|:||::|||.|:|:|.:::.:||:||||:|:|||.
  Rat   622 LVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIF 686

  Fly   682 TLGSTPYPGISAADVMRKVRDGYRLEKPEHCRRELYNIMYYCWSHDPQERPLFAEIIQMLDKLLH 746
            |||.:|||||...::.:.:::|:|::||.:|..:||.||..||...|.:||.|.::::.||::|.
  Rat   687 TLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAVPSQRPTFKQLVEDLDRILT 751

  Fly   747 -TEMD-YIEL 754
             |..| |::|
  Rat   752 VTSTDEYLDL 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637	24/129 (19%)
		STYKc	470..741	CDD:214568	123/275 (45%)
		PTKc	474..742	CDD:270623	122/272 (45%)
Fgfr3	XP_006251452.1	IGc2	51..108	CDD:197706	9/59 (15%)
		IG	52..123	CDD:214652	12/75 (16%)
		Ig2_FGFR	155..239	CDD:143265	18/110 (16%)
		IG_like	254..349	CDD:214653	22/117 (19%)
		Ig3_FGFR	262..350	CDD:143175	19/110 (17%)
		PTKc_FGFR3	457..790	CDD:173652	135/305 (44%)
		Pkinase_Tyr	470..746	CDD:285015	123/275 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810