DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad96Ca and MAP3K21

DIOPT Version :10

Sequence 1:NP_651349.1 Gene:Cad96Ca / 43026 FlyBaseID:FBgn0022800 Length:773 Species:Drosophila melanogaster
Sequence 2:NP_115811.2 Gene:MAP3K21 / 84451 HGNCID:29798 Length:1036 Species:Homo sapiens


Alignment Length:442 Identity:115/442 - (26%)
Similarity:174/442 - (39%) Gaps:116/442 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   410 STGVTNGGVSSPGVPSPGTGEPGSNLGPGCLTGGAG----------------------------- 445
            :.|.|:..|||.|....|:....|....|..:.|||                             
Human     6 AAGATDTPVSSAGGAPGGSASSSSTSSGGSASAGAGLWAALYDYEARGEDELSLRRGQLVEVLSQ 70

  Fly   446 --SSGAPENAFAGEANCDRWEFP-RY--------------------------RLKFFNILGEGAF 481
              :....|..:||:.......|| .|                          ||:...::|.|.|
Human    71 DAAVSGDEGWWAGQVQRRLGIFPANYVAPCRPAASPAPPPSRPSSPVHVAFERLELKELIGAGGF 135

  Fly   482 GQVWRCEATNINGNEGITTVAVKTLKE-------SATEVDRKDLLSELEVMKSLEPHINVVHLLG 539
            |||:|   ....|.|    ||||..::       :|.|..|:    |..:...|. |.|::.|.|
Human   136 GQVYR---ATWQGQE----VAVKAARQDPEQDAAAAAESVRR----EARLFAMLR-HPNIIELRG 188

  Fly   540 CCTDKDPTFVILEYVNRGKLQTYLRSSRA---ERHYGNTHGKSNVLTSCDLTSFMYQVAKGMDYL 601
            .|..:....::||:...|.|...|.::.|   .|..|....:.  :....|.::..|:|:||.||
Human   189 VCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARR--IPPHVLVNWAVQIARGMLYL 251

  Fly   602 TSRG---IIHRDLAARNILITD--DH------TCKVADFGFARD------VITSKIYERKSEGKL 649
            ....   |:||||.:.|||:.:  :|      |.|:.|||.||:      :.|:..|        
Human   252 HEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMSTAGTY-------- 308

  Fly   650 PIRWMATESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISAADVMRKVR-DGYRLEKPEHCR 713
              .|||.|.:..::||..|||||:|:|:||::| |..||.||....|...|. :...|..|..|.
Human   309 --AWMAPEVIKSSLFSKGSDIWSYGVLLWELLT-GEVPYRGIDGLAVAYGVAVNKLTLPIPSTCP 370

  Fly   714 RELYNIMYYCWSHDPQERPLFAEIIQMLDKLLHTEMDYIELERFPDHNYYNI 765
            .....:|..||..||..||.||.|::.|     |.::...:...|..:::::
Human   371 EPFAKLMKECWQQDPHIRPSFALILEQL-----TAIEGAVMTEMPQESFHSM 417

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad96CaNP_651349.1 Cadherin_repeat 65..164 CDD:206637
PTKc 474..742 CDD:270623 92/295 (31%)
MAP3K21NP_115811.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..36 9/29 (31%)
SH3_MLK4 42..97 CDD:212991 5/54 (9%)
Protein Kinases, catalytic domain 129..401 CDD:473864 94/301 (31%)
Leucine-zipper 1 425..446
Leucine-zipper 2 460..481
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 517..551
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 748..791
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 923..954
Blue background indicates that the domain is not in the aligned region.

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