DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad96Ca and Fgfr1

DIOPT Version :9

Sequence 1:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	NP_077060.1	Gene:	Fgfr1 / 79114	RGDID:	620713	Length:	822	Species:	Rattus norvegicus

Alignment Length:	891	Identity:	241/891 - (27%)
Similarity:	380/891 - (42%)	Gaps:	263/891 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 WRRRSLLLTIIVVTATVVSLISQEAEAHNQNAPP----------------ILYVRER-------- 62
            |..|.||...::||||:.:  ::.|....:.|.|                :|.:|.|
  Rat     2 WGWRGLLFWAVLVTATLCT--ARPAPTLPEQAQPWGVPVEVESLLVHPGDLLQLRCRLRDDVQSI 64

  Fly    63 NW-----RISETEKVG------QIIDRVRAE---------DPDGDD-LIFGIEPRFSLPGGE--- 103
            ||     :::|:.:..      ::.|.:.|:         .|.|.| ..|.:....:||..|
  Rat    65 NWLRDGVQLAESNRTRITGEEVEVRDSIPADSGLYACVTNSPSGSDTTYFSVNVSDALPSSEDDD 129

  Fly   104 --NDASPPEK-----------------IPFQIDRETGVVTLNESLAGRA---------------G 134
              :|:|..||                 .|.:::::...|...:::..:.               |
  Rat   130 DDDDSSSEEKETDNTKPNRRPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPSPTLRWLKNG 194

  Fly   135 QNF----------LIYIT---VTD-------GSYTAKNEVFINILGERENSSGYRPQTSISNVVH 179
            :.|          :.|.|   :.|       |:||.       |:   ||..|....|...:||
  Rat   195 KEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTC-------IV---ENEYGSINHTYQLDVV- 248

  Fly   180 NISQFLPRFDQLPGVQSIRNGLPNSRPGGWYPPVPQNNIFGPPPFGNN-------YPPPPPNIP- 236
                     ::.|....::.|||.::               ....|:|       |..|.|:|.
  Rat   249 ---------ERSPHRPILQAGLPANK---------------TVALGSNVEFMCKVYSDPQPHIQW 289

  Fly   237 ----GVRGEQSGEEEQPDEEVTPTTPVRISSTTPKSRTKLTPITANNSTRVESAIPAETTTPSG- 296
                .|.|.:.|.:..|.:::..|..|   :||.|....|      :...|......|.|..:|
  Rat   290 LKHIEVNGSKIGPDNLPYDQILKTAGV---NTTDKEMEVL------HLRNVSFEDAGEYTCLAGN 345

  Fly   297 ----GHHNNSSSPITIFSLKSG-----TIP-----IVVTVGGFFVAIAVLLAYLCRRRLCAI-SR 346
                .||   |:.:|:......     |.|     |:...|.|.::             |.: |.
  Rat   346 SIGLSHH---SAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLIS-------------CMVGSV 394

  Fly   347 TLKKTKEKEELAKKSNQSQLSSTLTDDSRNSMVMQQWQGPVAFANRYVPWERDQQMGIATSQLST 411
            .:.|.|              |.|...|..:.|.:.:       ..:.:|..|.    :..|..|:
  Rat   395 IIYKMK--------------SGTKKSDFHSQMAVHK-------LAKSIPLRRQ----VTVSADSS 434

  Fly   412 GVTNGGV--------SSPGVPSPGTGEPGSNLGPGCLTGGAGSSGAPENAFAGEANCDRWEFPRY 468
            ...|.||        ||.|.|               :..|......||:        .|||.||.
  Rat   435 ASMNSGVLLVRPSRLSSSGTP---------------MLAGVSEYELPED--------PRWELPRD 476

  Fly   469 RLKFFNILGEGAFGQVWRCEATNINGNE--GITTVAVKTLKESATEVDRKDLLSELEVMKSLEPH 531
            ||.....||||.||||...||..::.::  .:|.||||.||..|||.|..||:||:|:||.:..|
  Rat   477 RLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKH 541

  Fly   532 INVVHLLGCCTDKDPTFVILEYVNRGKLQTYLRSSR---AERHYGNTHGKSNVLTSCDLTSFMYQ 593
            .|:::|||.||...|.:||:||.::|.|:.||::.|   .|..|..:|.....|:|.||.|..||
  Rat   542 KNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQ 606

  Fly   594 VAKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFGFARDVITSKIYERKSEGKLPIRWMATES 658
            ||:||:||.|:..|||||||||:|:|:|:..|:||||.|||:.....|::.:.|:||::|||.|:
  Rat   607 VARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEA 671

  Fly   659 LYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISAADVMRKVRDGYRLEKPEHCRRELYNIMYYC 723
            |:|.|::.:||:||||:|:|||.|||.:|.||:...::.:.:::|:|::||.:|..|||.:|..|
  Rat   672 LFDRIYTHQSDVWSFGVLLWEIFTLGGSPNPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDC 736

  Fly   724 WSHDPQERPLFAEIIQMLDKL--LHTEMDYIELE--------RFPD 759
            |:..|.:||.|.::::.||::  |.:..:|::|.        .|||
  Rat   737 WNAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQDSPSFPD 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637	25/171 (15%)
		STYKc	470..741	CDD:214568	125/275 (45%)
		PTKc	474..742	CDD:270623	124/272 (46%)
Fgfr1	NP_077060.1	Ig1_FGFR	40..118	CDD:143174	12/77 (16%)
		IG_like	41..118	CDD:214653	12/76 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..162		8/41 (20%)
		I-set	160..247	CDD:254352	14/96 (15%)
		Heparin-binding	160..177		1/16 (6%)
		Ig2_FGFR	163..247	CDD:143265	14/93 (15%)
		IG_like	262..358	CDD:214653	24/122 (20%)
		Ig3_FGFR	270..359	CDD:143175	24/100 (24%)
		PTKc_FGFR1	464..765	CDD:270678	136/308 (44%)
		Pkinase_Tyr	478..754	CDD:285015	125/275 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	770..822		3/13 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	4	3.770