Protein Alignment Cad96Ca and ZAP70

DIOPT Version :10

• Sequence 1: NP_651349.1
• Gene: Cad96Ca / 43026
• FlyBaseID: FBgn0022800
• Length: 773
• Species: Drosophila melanogaster
• Sequence 2: XP_054188971.1
• Gene: ZAP70 / 7535
• HGNCID: 12858
• Length: 707
• Species: Homo sapiens
• Alignment Length: 753
• Identity: 174/753 - (23%)
• Similarity: 267/753 - (35%)
• Gaps: 233/753 - (30%)

  Fly   100 PGGENDASPPEKIPF---QIDRETGVVTLNESLAGRAGQNFLIYITVTDGSYTAKNEVFINILGE 161
            ||...|  |...:||   .|.|......|  .|||.|...||:             ...:..||
Human    86 PGAMPD--PAAHLPFFYGSISRAEAEEHL--KLAGMADGLFLL-------------RQCLRSLG- 132

  Fly   162 RENSSGYRPQTSISNVVHNIS-QFLPRFDQLPGVQSIRNGLPNSRPGGWYPPVPQNNIFGPPPFG 225
                 ||     :.::||::. ...|...||.|..:|..|..:.               ||....
Human   133 -----GY-----VLSLVHDVRFHHFPIERQLNGTYAIAGGKAHC---------------GPAELC 172

  Fly   226 NNYPPPPPNIP-GVR---GEQSGEEEQP--------------------------DEEVTPTTP-- 258
            ..|...|..:| .:|   ...||.|.||                          ::.:....|
Human   173 EFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRDAMVRDYVRQTWKLEGEALEQAIISQAPQV 237

  Fly   259 VRISSTTPKSRTKLTPITANNSTRVESAIPAETTTPSGGHHNNSSSPITIFSLK----SGTIPI- 318
            .::.:||...|   .|...::.||.|    ||....||...:..      |.|:    .||..:
Human   238 EKLIATTAHER---MPWYHSSLTREE----AERKLYSGAQTDGK------FLLRPRKEQGTYALS 289

  Fly   319 --------------------VVTVGGFFVAIAVLLAYL---------CRRRLCAISRTLKKTKEK 354
                                .:..|..|..:..|:.||         |.:..|..|
Human   290 LIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNS--------- 345

  Fly   355 EELAKKSNQSQLS--------STLTDDSRNSMVMQQWQGPVAFANRYVPWERDQQMGIATSQLST 411
                ..||.|..:        ||||...|....:.        ::.|.|
Human   346 ----SASNASGAAAPTLPAHPSTLTHPQRRIDTLN--------SDGYTP---------------- 382

  Fly   412 GVTNGGVSSPGVPSPGTGEPGSNLGPGCLTGGAGSSGAPENAFAGEANCDRWEFPRYRLKFFNI- 475
              ....::||..|.|...:......|         ...||     |....:....|..|...:|
Human   383 --EPARITSPDKPRPMPMDTSVYESP---------YSDPE-----ELKDKKLFLKRDNLLIADIE 431

  Fly   476 LGEGAFGQ----VWRCEATNINGNEGITTVAVKTLKESATEVDRKDLLSELEVMKSLE-PHINVV 535
            ||.|.||.    |:|.....|:       ||:|.||:...:.|.::::.|.::|..|: |:|  |
Human   432 LGCGNFGSVRQGVYRMRKKQID-------VAIKVLKQGTEKADTEEMMREAQIMHQLDNPYI--V 487

  Fly   536 HLLGCCTDKDPTFVILEYVNRGKLQTYLRSSRAERHYGNTHGKSNVLTSCDLTSFMYQVAKGMDY 600
            .|:|.| ..:...:::|....|.|..:|...|.|....|            :...::||:.||.|
Human   488 RLIGVC-QAEALMLVMEMAGGGPLHKFLVGKREEIPVSN------------VAELLHQVSMGMKY 539

  Fly   601 LTSRGIIHRDLAARNILITDDHTCKVADFGFARDV-ITSKIYERKSEGKLPIRWMATESLYDNIF 664
            |..:..:||||||||:|:.:.|..|::|||.::.: .....|..:|.||.|::|.|.|.:....|
Human   540 LEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKF 604

  Fly   665 SVKSDIWSFGILMWEIVTLGSTPYPGISAADVMRKVRDGYRLEKPEHCRRELYNIMYYCWSHDPQ 729
            |.:||:||:|:.|||.::.|..||..:...:||..:..|.|:|.|..|..|||.:|..||.:..:
Human   605 SSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWE 669

  Fly   730 ERPLFAEIIQMLDKLLHTEMDYIELERFPDHNYYNIVS 767
            :||                 |::.:|:.....||::.|
Human   670 DRP-----------------DFLTVEQRMRACYYSLAS 690

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637	17/66 (26%)
		PTKc	474..742	CDD:270623	87/274 (32%)
ZAP70	XP_054188971.1	SH2_N-SH2_Zap70_Syk_like	96..199	CDD:198191	32/143 (22%)
		SH2_C-SH2_Zap70	240..343	CDD:198265	21/115 (18%)
		PTKc_Zap-70	421..689	CDD:270686	93/306 (30%)