DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad96Ca and TEK

DIOPT Version :10

Sequence 1:NP_651349.1 Gene:Cad96Ca / 43026 FlyBaseID:FBgn0022800 Length:773 Species:Drosophila melanogaster
Sequence 2:NP_000450.3 Gene:TEK / 7010 HGNCID:11724 Length:1124 Species:Homo sapiens


Alignment Length:875 Identity:222/875 - (25%)
Similarity:339/875 - (38%) Gaps:249/875 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 VTATVVSLISQEAEAHNQNAPPILYVRERNWRISETEKVGQIIDRVRAEDPDGDDL---IFGIEP 95
            :|..:|.| ....|.::....||  .:...|.:...|::..:       .|||..|   .|....
Human   348 MTPKIVDL-PDHIEVNSGKFNPI--CKASGWPLPTNEEMTLV-------KPDGTVLHPKDFNHTD 402

  Fly    96 RFSLPGGENDASPPEKIPFQIDR----ETGV-VTLNESLAGRAGQNFLIYITVTDGSYTAKNEV- 154
            .||:            ..|.|.|    ::|| |....::||...:.|.|.:.|......|.|.: 
Human   403 HFSV------------AIFTIHRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVID 455

  Fly   155 ------FINILGERENSSG--------YRP--------QTSISNVVHNISQFLPRFDQLPGVQSI 197
                  .|||..|.....|        |:|        ...::|.:..::...||.:....||.:
Human   456 TGHNFAVINISSEPYFGDGPIKSKKLLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLV 520

  Fly   198 RNG----------------------------LPNSRPG---GWYPPVP----------------- 214
            |.|                            ||.|:..   .|.|..|                 
Human   521 RRGEGGEGHPGPVRRFTTASIGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQK 585

  Fly   215 --QNNIFGPPPFG----NNYPPPPPNIPGVRGEQSGEEEQPDE-------EVTPTTP--VRISST 264
              |.||..|....    ||..|....:...|.....:.|..::       ::.|..|  ::||:.
Human   586 SDQQNIKVPGNLTSVLLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNI 650

  Fly   265 TPKSRT---------KLTPIT-------ANNSTRVESAIPAETTT--------PSGGH------H 299
            |..|..         .::.||       .|....|:..|...|.|        |...:      .
Human   651 THSSAVISWTILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPETAYQVDIFAE 715

  Fly   300 NNSSSPITIFSLKSGTIP---------------IVVTVGGFFVAIAVLLAYLCRRRLCAISRTLK 349
            ||..|....||.:..|:|               |.:........:.||||:|       |...||
Human   716 NNIGSSNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFL-------IILQLK 773

  Fly   350 KTKEKEELAKKSNQSQLSSTLTDDSRNSMVMQQWQGPVAFANRYVPWERDQQMGIATSQLSTGVT 414
            :...:..:|:                            ||.|  |..|...|....|..|:..|.
Human   774 RANVQRRMAQ----------------------------AFQN--VREEPAVQFNSGTLALNRKVK 808

  Fly   415 NGGVSSPGVPSPGTGEPGSNLGPGCLTGGAGSSGAPENAFAGEANCDRWEFPRYRLKFFNILGEG 479
            |.       |.| |..|..:                            |.    .:||.:::|||
Human   809 NN-------PDP-TIYPVLD----------------------------WN----DIKFQDVIGEG 833

  Fly   480 AFGQVWRCEATNINGNEGI-TTVAVKTLKESATEVDRKDLLSELEVMKSLEPHINVVHLLGCCTD 543
            .||||.:....    .:|: ...|:|.:||.|::.|.:|...||||:..|..|.|:::|||.|..
Human   834 NFGQVLKARIK----KDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEH 894

  Fly   544 KDPTFVILEYVNRGKLQTYLRSSR---AERHYGNTHGKSNVLTSCDLTSFMYQVAKGMDYLTSRG 605
            :...::.:||...|.|..:||.||   .:..:...:..::.|:|..|..|...||:|||||:.:.
Human   895 RGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQ 959

  Fly   606 IIHRDLAARNILITDDHTCKVADFGFARDVITSKIYERKSEGKLPIRWMATESLYDNIFSVKSDI 670
            .|||||||||||:.:::..|:||||.:|.   .::|.:|:.|:||:||||.|||..::::..||:
Human   960 FIHRDLAARNILVGENYVAKIADFGLSRG---QEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDV 1021

  Fly   671 WSFGILMWEIVTLGSTPYPGISAADVMRKVRDGYRLEKPEHCRRELYNIMYYCWSHDPQERPLFA 735
            ||:|:|:||||:||.|||.|::.|::..|:..|||||||.:|..|:|::|..||...|.|||.||
Human  1022 WSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFA 1086

  Fly   736 EIIQMLDKLLHTEMDYIELERFPDHNYYNI 765
            :|:..|:::|.....|:....:....|..|
Human  1087 QILVSLNRMLEERKTYVNTTLYEKFTYAGI 1116

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad96CaNP_651349.1 Cadherin_repeat 65..164 CDD:206637 25/113 (22%)
PTKc 474..742 CDD:270623 112/271 (41%)
TEKNP_000450.3 Ig_Tie2_1 24..118 CDD:463089
EGF_Lam 230..275 CDD:238012
EGF_Lam 314..>342 CDD:238012
IgI_Tie2 348..439 CDD:409556 24/112 (21%)
Ig strand A 348..352 CDD:409556 1/3 (33%)
Ig strand A' 358..362 CDD:409556 1/3 (33%)
Ig strand B 365..374 CDD:409556 2/10 (20%)
Ig strand C 382..387 CDD:409556 0/11 (0%)
Ig strand C' 391..393 CDD:409556 0/1 (0%)
Ig strand D 397..401 CDD:409556 1/3 (33%)
Ig strand E 404..412 CDD:409556 3/19 (16%)
Ig strand F 420..428 CDD:409556 3/7 (43%)
Ig strand G 431..439 CDD:409556 2/7 (29%)
fn3 445..520 CDD:394996 14/74 (19%)
fn3 544..626 CDD:394996 15/81 (19%)
FN3 639..731 CDD:238020 19/91 (21%)
PTKc_Tie2 816..1118 CDD:133219 121/340 (36%)
Blue background indicates that the domain is not in the aligned region.

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