DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad96Ca and TEK

DIOPT Version :9

Sequence 1:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	NP_000450.3	Gene:	TEK / 7010	HGNCID:	11724	Length:	1124	Species:	Homo sapiens

Alignment Length:	875	Identity:	222/875 - (25%)
Similarity:	339/875 - (38%)	Gaps:	249/875 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VTATVVSLISQEAEAHNQNAPPILYVRERNWRISETEKVGQIIDRVRAEDPDGDDL---IFGIEP 95
            :|..:|.| ....|.::....||  .:...|.:...|::..:       .|||..|   .|....
Human   348 MTPKIVDL-PDHIEVNSGKFNPI--CKASGWPLPTNEEMTLV-------KPDGTVLHPKDFNHTD 402

  Fly    96 RFSLPGGENDASPPEKIPFQIDR----ETGV-VTLNESLAGRAGQNFLIYITVTDGSYTAKNEV- 154
            .||:            ..|.|.|    ::|| |....::||...:.|.|.:.|......|.|.:
Human   403 HFSV------------AIFTIHRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVID 455

  Fly   155 ------FINILGERENSSG--------YRP--------QTSISNVVHNISQFLPRFDQLPGVQSI 197
                  .|||..|.....|        |:|        ...::|.:..::...||.:....||.:
Human   456 TGHNFAVINISSEPYFGDGPIKSKKLLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLV 520

  Fly   198 RNG----------------------------LPNSRPG---GWYPPVP----------------- 214
            |.|                            ||.|:..   .|.|..|
Human   521 RRGEGGEGHPGPVRRFTTASIGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQK 585

  Fly   215 --QNNIFGPPPFG----NNYPPPPPNIPGVRGEQSGEEEQPDE-------EVTPTTP--VRISST 264
              |.||..|....    ||..|....:...|.....:.|..::       ::.|..|  ::||:.
Human   586 SDQQNIKVPGNLTSVLLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNI 650

  Fly   265 TPKSRT---------KLTPIT-------ANNSTRVESAIPAETTT--------PSGGH------H 299
            |..|..         .::.||       .|....|:..|...|.|        |...:      .
Human   651 THSSAVISWTILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPETAYQVDIFAE 715

  Fly   300 NNSSSPITIFSLKSGTIP---------------IVVTVGGFFVAIAVLLAYLCRRRLCAISRTLK 349
            ||..|....||.:..|:|               |.:........:.||||:|       |...||
Human   716 NNIGSSNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFL-------IILQLK 773

  Fly   350 KTKEKEELAKKSNQSQLSSTLTDDSRNSMVMQQWQGPVAFANRYVPWERDQQMGIATSQLSTGVT 414
            :...:..:|:                            ||.|  |..|...|....|..|:..|.
Human   774 RANVQRRMAQ----------------------------AFQN--VREEPAVQFNSGTLALNRKVK 808

  Fly   415 NGGVSSPGVPSPGTGEPGSNLGPGCLTGGAGSSGAPENAFAGEANCDRWEFPRYRLKFFNILGEG 479
            |.       |.| |..|..:                            |.    .:||.:::|||
Human   809 NN-------PDP-TIYPVLD----------------------------WN----DIKFQDVIGEG 833

  Fly   480 AFGQVWRCEATNINGNEGI-TTVAVKTLKESATEVDRKDLLSELEVMKSLEPHINVVHLLGCCTD 543
            .||||.:....    .:|: ...|:|.:||.|::.|.:|...||||:..|..|.|:::|||.|..
Human   834 NFGQVLKARIK----KDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEH 894

  Fly   544 KDPTFVILEYVNRGKLQTYLRSSR---AERHYGNTHGKSNVLTSCDLTSFMYQVAKGMDYLTSRG 605
            :...::.:||...|.|..:||.||   .:..:...:..::.|:|..|..|...||:|||||:.:.
Human   895 RGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQ 959

  Fly   606 IIHRDLAARNILITDDHTCKVADFGFARDVITSKIYERKSEGKLPIRWMATESLYDNIFSVKSDI 670
            .|||||||||||:.:::..|:||||.:|.   .::|.:|:.|:||:||||.|||..::::..||:
Human   960 FIHRDLAARNILVGENYVAKIADFGLSRG---QEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDV 1021

  Fly   671 WSFGILMWEIVTLGSTPYPGISAADVMRKVRDGYRLEKPEHCRRELYNIMYYCWSHDPQERPLFA 735
            ||:|:|:||||:||.|||.|::.|::..|:..|||||||.:|..|:|::|..||...|.|||.||
Human  1022 WSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFA 1086

  Fly   736 EIIQMLDKLLHTEMDYIELERFPDHNYYNI 765
            :|:..|:::|.....|:....:....|..|
Human  1087 QILVSLNRMLEERKTYVNTTLYEKFTYAGI 1116

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637	25/113 (22%)
		STYKc	470..741	CDD:214568	114/274 (42%)
		PTKc	474..742	CDD:270623	112/271 (41%)
TEK	NP_000450.3	Ig_Tie2_1	24..118	CDD:402176
		EGF_Lam	230..275	CDD:238012
		EGF_Lam	314..>342	CDD:238012
		IgI_Tie2	348..439	CDD:409556	24/112 (21%)
		Ig strand B	366..370	CDD:409556	2/5 (40%)
		Ig strand C	382..386	CDD:409556	0/3 (0%)
		Ig strand E	407..411	CDD:409556	1/3 (33%)
		Ig strand F	421..426	CDD:409556	2/4 (50%)
		Ig strand G	434..437	CDD:409556	0/2 (0%)
		fn3	445..520	CDD:394996	14/74 (19%)
		fn3	544..626	CDD:394996	15/81 (19%)
		FN3	639..731	CDD:238020	19/91 (21%)
		PTKc_Tie2	816..1118	CDD:133219	121/340 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910