Protein Alignment Cad96Ca and TEC

DIOPT Version :10

• Sequence 1: NP_651349.1
• Gene: Cad96Ca / 43026
• FlyBaseID: FBgn0022800
• Length: 773
• Species: Drosophila melanogaster
• Sequence 2: XP_047272062.1
• Gene: TEC / 7006
• HGNCID: 11719
• Length: 722
• Species: Homo sapiens
• Alignment Length: 710
• Identity: 168/710 - (23%)
• Similarity: 258/710 - (36%)
• Gaps: 232/710 - (32%)

  Fly   111 KIPFQI---------------DRETGVVTLNESLAGRAGQNFLIYITV---TDGSYTAKNEVFIN 157
            |.|||:               .|:..|..|.|.:  :...|.:|....   |||||
Human   168 KYPFQVVHDANTLYIFAPSPQSRDLWVKKLKEEI--KNNNNIMIKYHPKFWTDGSY--------- 221

  Fly   158 ILGERENSSGYRPQTSISNVVHNISQFLPRFDQL-PGVQ-------SIRNGLPNSRPGGWYPPVP 214
                                     |...:.::| ||.:       |||..|         ||.|
Human   222 -------------------------QCCRQTEKLAPGCEKYNLFESSIRKAL---------PPAP 252

  Fly   215 QNNIFGPPPFGNNYPPPPPNIPGVRGEQSGEEEQPDEEVTPTT---------PVRISSTTPKSRT 270
            :..        ...||||  ||       .|||...||:....         .:|:      .|.
Human   253 ETK--------KRRPPPP--IP-------LEEEDNSEEIVVAMYDFQAAEGHDLRL------ERG 294

  Fly   271 KLTPITANNSTR---------VESAIPAETTTPSGGHHNNSSSPITIFSLKSGTIPIVVTVGGFF 326
            :...|...|...         .|..||:...|  |...||...
Human   295 QEYLILEKNDVHWWRARDKYGNEGYIPSNYVT--GKKSNNLDQ---------------------- 335

  Fly   327 VAIAVLLAYLCRRRLCAISRTLKKTKEKEE--LAKKSNQS----------------------QLS 367
                  ..:.||....:.:..|.::::||.  :.:.|:|.                      .:.
Human   336 ------YEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHYHIK 394

  Fly   368 STLTDDSRNSMVMQQWQGPVAFANRYVPWERDQQMGIATSQLSTGVTNGGVSSPGVPSPGTGEPG 432
            .|.|...:..:..:...|.:.   ..:.:.:....|:.|.      ....||..|..:|.|
Human   395 ETTTSPKKYYLAEKHAFGSIP---EIIEYHKHNAAGLVTR------LRYPVSVKGKNAPTT---- 446

  Fly   433 SNLGPGCLTGGAGSSGAPENAFAGEANCDRWEFPRYRLKFFNILGEGAFGQV----WRCEATNIN 493
                       ||.|            .::||.....|.|...||.|.||.|    ||.:
Human   447 -----------AGFS------------YEKWEINPSELTFMRELGSGLFGVVRLGKWRAQ----- 483

  Fly   494 GNEGITTVAVKTLKESATEVDRKDLLSELEVMKSLEPHINVVHLLGCCTDKDPTFVILEYVNRGK 558
                 ..||:|.::|.|  :..:|.:.|.:||..| .|..:|.|.|.||.:.|.:::.|::.||.
Human   484 -----YKVAIKAIREGA--MCEEDFIEEAKVMMKL-THPKLVQLYGVCTQQKPIYIVTEFMERGC 540

  Fly   559 LQTYLRSSRAERHYGNTHGKSNVLTSCDLTSFMYQVAKGMDYLTSRGIIHRDLAARNILITDDHT 623
            |..:||  :.:.|:    .:..:|:.|.      .|.:||:||.....|||||||||.|:::...
Human   541 LLNFLR--QRQGHF----SRDVLLSMCQ------DVCEGMEYLERNSFIHRDLAARNCLVSEAGV 593

  Fly   624 CKVADFGFARDVITSKIYERKSEGKLPIRWMATESLYDNIFSVKSDIWSFGILMWEIVTLGSTPY 688
            .||:|||.||.|:..: |...|..|.|::|...|....:.||.|||:||||:||||:.|.|..|:
Human   594 VKVSDFGMARYVLDDQ-YTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPF 657

  Fly   689 PGISAADVMRKVRDGYRLEKPEHCRRELYNIMYYCWSHDPQERPLFAEIIQMLDKLLHTE 748
            ...:..:|:..|..|:||.:|:.....:|.:|..||...|:.||.|.::::.:|:|:..|
Human   658 EKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVECE 717

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637	15/70 (21%)
		PTKc	474..742	CDD:270623	93/271 (34%)
TEC	XP_047272062.1	PH_Btk	98..239	CDD:269944	19/106 (18%)
		SH3_Tec	273..328	CDD:212838	9/62 (15%)
		SH2_Tec_Itk	331..437	CDD:198259	14/142 (10%)
		PTKc_Tec_Rlk	456..715	CDD:270685	97/284 (34%)