Protein Alignment Cad96Ca and BTK

DIOPT Version :10

• Sequence 1: NP_651349.1
• Gene: Cad96Ca / 43026
• FlyBaseID: FBgn0022800
• Length: 773
• Species: Drosophila melanogaster
• Sequence 2: NP_001274273.1
• Gene: BTK / 695
• HGNCID: 1133
• Length: 693
• Species: Homo sapiens
• Alignment Length: 785
• Identity: 192/785 - (24%)
• Similarity: 281/785 - (35%)
• Gaps: 239/785 - (30%)

  Fly    23 RRRSLLLTIIVVTATVVSLISQEAEAHNQNAPPILYVRERNWRISETEKVGQIIDRVRAEDPDGD 87
            ||.|...:|.|...|.|..:..|     :|.||...:..|....||.|:: .||:|.    |...
Human    82 RRGSKKGSIDVEKITCVETVVPE-----KNPPPERQIPRRGEESSEMEQI-SIIERF----PYPF 136

  Fly    88 DLIFGIEPRFSLPGGENDASPPEKIPFQ-IDRETGVVTLNESLAGRAGQNFLIYITVTDGSY--- 148
            .:::...|.:..       ||.|::..: |.:...|:..|..|..:....|.|     ||.|
Human   137 QVVYDEGPLYVF-------SPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWI-----DGQYLCC 189

  Fly   149 --TAKNEVFINILGERENSSGYRPQTSISNVVHNISQFLPRFDQLPGVQSIRNGLPNSRPGGWYP 211
              ||||.:...||   ||.:|                            |::.|..:.:.....|
Human   190 SQTAKNAMGCQIL---ENRNG----------------------------SLKPGSSHRKTKKPLP 223

  Fly   212 PVPQNNIFGPPPFGNNYPPPPPNIPGVRGEQSGEEEQPDEEVTPTTPVRISSTTPKSRTKL---T 273
            |.|:.:.....|.    ||.|...|                        :|::..|....|   .
Human   224 PTPEEDQILKKPL----PPEPAAAP------------------------VSTSELKKVVALYDYM 260

  Fly   274 PITANNSTRVESAIPAETTTPSGGHHNNSSSPITIFSLKSGTIPIVVTVGGFFVAIAVLLAYLCR 338
            |:.||           :.....|..:         |.|:...:|                  ..|
Human   261 PMNAN-----------DLQLRKGDEY---------FILEESNLP------------------WWR 287

  Fly   339 RRLCAISRTLKKTKEKEELAKKSNQSQLSSTLTDDSRNSMVMQQWQGPVAFANRYVPWERDQ--- 400
            .|                 .|...:..:.|....::.:|:.|.:|     ::......:.:|
Human   288 AR-----------------DKNGQEGYIPSNYVTEAEDSIEMYEW-----YSKHMTRSQAEQLLK 330

  Fly   401 QMGIATSQLSTGVTNGGVSSPGVPSPGTGEPGSNLGPG-------CLT----------------- 441
            |.|.....:....:..|..:..|.:..||:|     .|       |.|
Human   331 QEGKEGGFIVRDSSKAGKYTVSVFAKSTGDP-----QGVIRHYVVCSTPQSQYYLAEKHLFSTIP 390

  Fly   442 --------GGAG------------SSGAPENAFAGEANCDRWEFPRYRLKFFNILGEGAFGQV-- 484
                    ..||            :..||..|..|..:   ||.....|.|...||.|.||.|
Human   391 ELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGS---WEIDPKDLTFLKELGTGQFGVVKY 452

  Fly   485 --WRCEATNINGNEGITTVAVKTLKESATEVDRKDLLSELEVMKSLEPHINVVHLLGCCTDKDPT 547
              ||          |...||:|.:||.:...|  :.:.|.:||.:|. |..:|.|.|.||.:.|.
Human   453 GKWR----------GQYDVAIKMIKEGSMSED--EFIEEAKVMMNLS-HEKLVQLYGVCTKQRPI 504

  Fly   548 FVILEYVNRGKLQTYLRSSRAERHYGNTHGKSNVLTSCDLTSFMYQVAKGMDYLTSRGIIHRDLA 612
            |:|.||:..|.|..|||..   ||...|   ..:|..|.      .|.:.|:||.|:..:|||||
Human   505 FIITEYMANGCLLNYLREM---RHRFQT---QQLLEMCK------DVCEAMEYLESKQFLHRDLA 557

  Fly   613 ARNILITDDHTCKVADFGFARDVITSKIYERKSEGKLPIRWMATESLYDNIFSVKSDIWSFGILM 677
            |||.|:.|....||:|||.:|.|:..: |......|.|:||...|.|..:.||.|||||:||:||
Human   558 ARNCLVNDQGVVKVSDFGLSRYVLDDE-YTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLM 621

  Fly   678 WEIVTLGSTPYPGISAADVMRKVRDGYRLEKPEHCRRELYNIMYYCWSHDPQERPLF----AEII 738
            |||.:||..||...:.::....:..|.||.:|.....::|.|||.||.....|||.|    :.|:
Human   622 WEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNIL 686

  Fly   739 QMLDK 743
            .::|:
Human   687 DVMDE 691

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637	26/104 (25%)
		PTKc	474..742	CDD:270623	102/275 (37%)
BTK	NP_001274273.1	PH_Btk	40..200	CDD:269944	36/139 (26%)
		SH3_BTK	251..305	CDD:212839	13/108 (12%)
		SH2_Tec_Btk	308..413	CDD:198260	16/114 (14%)
		PTKc_Btk_Bmx	431..686	CDD:173657	103/280 (37%)