Protein Alignment Cad96Ca and SRMS

DIOPT Version :10

• Sequence 1: NP_651349.1
• Gene: Cad96Ca / 43026
• FlyBaseID: FBgn0022800
• Length: 773
• Species: Drosophila melanogaster
• Sequence 2: NP_543013.1
• Gene: SRMS / 6725
• HGNCID: 11298
• Length: 488
• Species: Homo sapiens
• Alignment Length: 285
• Identity: 105/285 - (36%)
• Similarity: 157/285 - (55%)
• Gaps: 29/285 - (10%)

  Fly   461 DRWEFPRYRLKFFNILGEGAFGQVWRCEATNINGNEGI----TTVAVKTLKESATEVDRKDLLSE 521
            |.||.|.........||||.||:||          ||:    ..||:|.:|.:..::  .||..|
Human   221 DVWERPHSEFALGRKLGEGYFGEVW----------EGLWLGSLPVAIKVIKSANMKL--TDLAKE 273

  Fly   522 LEVMKSLEPHINVVHLLGCCTDKDPTFVILEYVNRGKLQTYLRSSRAERHYGNTHGKSNVLTSCD 586
            ::.:|.|. |..::.|...|:..:|.:::.|.:.:|.||.:|         |...|::  |....
Human   274 IQTLKGLR-HERLIRLHAVCSGGEPVYIVTELMRKGNLQAFL---------GTPEGRA--LRLPP 326

  Fly   587 LTSFMYQVAKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFGFARDVITSKIYERKSEGKLPI 651
            |..|..|||:||.||..:.::||||||||:|:.|...|||||||.|| ::...||...|..|:|:
Human   327 LLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLAR-LLKDDIYSPSSSSKIPV 390

  Fly   652 RWMATESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISAADVMRKVRDGYRLEKPEHCRREL 716
            :|.|.|:....:||.|||:||||:|:.|:.|.|..||.|::..:.::::..||||.:|..|..|:
Human   391 KWTAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEV 455

  Fly   717 YNIMYYCWSHDPQERPLFAEIIQML 741
            |.:|..||...|:|||.||.:.:.|
Human   456 YVLMLECWRSSPEERPSFATLREKL 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637
		PTKc	474..742	CDD:270623	101/272 (37%)
SRMS	NP_543013.1	SH3_Srms	55..109	CDD:212780
		SH2	119..197	CDD:472789
		PTKc_Srm_Brk	223..483	CDD:133248	104/283 (37%)