DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad96Ca and flt3

DIOPT Version :9

Sequence 1:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	XP_001921760.3	Gene:	flt3 / 566708	ZFINID:	ZDB-GENE-050114-4	Length:	956	Species:	Danio rerio

Alignment Length:	385	Identity:	129/385 - (33%)
Similarity:	198/385 - (51%)	Gaps:	83/385 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   462 RWEFPRYRLKFFNILGEGAFGQVWRCEATNINGNEGITT-VAVKTLKESATEVDRKDLLSELEVM 525
            :|||||..|:..|.||.||||.|.:..|..|: ..|::. ||||.|||....|:::.|:|||:::
Zfish   552 KWEFPRENLELGNELGSGAFGMVVQATAYGIS-KPGVSVQVAVKMLKEKHQAVEKEALMSELKML 615

  Fly   526 KSLEPHINVVHLLGCCTDKDPTFVILEYVNRGKLQTYLRSSR------------AERHYGNTHG- 577
            ..:..|.|:|:|||.||...|.::|.::...|.|..||:|:|            .:|..|..|.
Zfish   616 THIGHHENIVNLLGACTGSGPIYLIFQFCCNGDLLNYLKSNRECFHKYLTDAFNKDRFRGLYHNF 680

  Fly   578 -----------------------------------KSNV-----------------------LTS 584
                                               .|::                       ||.
Zfish   681 QQNRNSSEYVLSDNSQCLNVTPASKEQENENDALLSSSISSGSPAEEMLECEDEHQEEELHSLTY 745

  Fly   585 CDLTSFMYQVAKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFGFARDVITSKIYERKSEGKL 649
            .||.||.:||||||.:|:::..|||||||||:|:|.....|:||||.|||:.....|..:...:|
Zfish   746 DDLLSFSFQVAKGMQFLSAKNCIHRDLAARNVLVTHGRQVKIADFGLARDIEHDSNYVVRGNVRL 810

  Fly   650 PIRWMATESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISAADVM-RKVRDGYRLEKPEHCR 713
            |::|||.||::..|::::||||::|||:|||.:||.|||||::..:.. |.:..||.||:|.:..
Zfish   811 PVKWMAPESIFKGIYTMESDIWAYGILLWEIFSLGVTPYPGVTVNNTFYRMIESGYHLEQPYYAA 875

  Fly   714 RELYNIMYYCWSHDPQERPLFAEIIQMLDKLLHTEMDYIELERFPDHNYYNIVSLSGEKL 773
            ..:|.:|..||:.:|.:||.|::|:..::|         ||....:..|||:...|.:::
Zfish   876 ESVYKVMCRCWALNPVDRPCFSKIVAFMEK---------ELAALEERLYYNVGGYSHDEI 926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637
		STYKc	470..741	CDD:214568	117/343 (34%)
		PTKc	474..742	CDD:270623	116/340 (34%)
flt3	XP_001921760.3	IGc2	225..283	CDD:197706
flt3	XP_001921760.3	PKc_like	522..907	CDD:328722	123/364 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910