DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Ca and kdr

DIOPT Version :9

Sequence 1:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	NP_001019824.2	Gene:	kdr / 554230	ZFINID:	ZDB-GENE-041001-112	Length:	1357	Species:	Danio rerio

Alignment Length:	931	Identity:	236/931 - (25%)
Similarity:	353/931 - (37%)	Gaps:	333/931 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RSLLLTIIVVTATVVSLISQEAEAHNQNAPPILYVRERNWRISETEK------VGQIIDRVRAED 83
            |.:.|||..||         |.:|.|       |......:|::.|:      |...:.|:..:|
Zfish   391 RGVHLTIYGVT---------EKDAGN-------YTVVMTNKITKEEQRRTFQLVVNDLPRIFEKD 439

  Fly    84 P--DGDDLIFGIEPRFSLPGGENDASPPEKIPFQ-IDRETGVVTLNESLAGRAGQNFLIYITVTD 145
            .  |.|..::|..|..:..|  :..|.|..|.:| :.||...|.               ::..:|
Zfish   440 VSLDRDVHMYGSSPTLTCTG--SGGSSPVTIKWQWMPREDCPVR---------------FLPKSD 487

  Fly   146 GSYTAKNEVFINILGERENSSGYRP---QTSISN------------------------------- 176
            .| .||.:.:    .|..|::|..|   |||:..
Zfish   488 PS-MAKCDKW----REMSNNTGKNPLISQTSVDERTLKTISTLKIQKAVDHALYRCIATNKMGQD 547

  Fly   177 ---VVHNISQF-----LPRFDQLPGVQSIRNGLP------NSRPGGWYPPVPQNNIFGPPPFGNN 227
               :|..:::|     ||....:.|...|...:.      |.|   ||...   |:       .|
Zfish   548 QRVIVFQVTRFLNLSVLPSSSPIEGQDVIMRCVADRLLYYNLR---WYRVA---NV-------AN 599

  Fly   228 YPPPPPNIP-----------------GVRG------------------------EQSGEEE---- 247
            :.|||..:|                 |::|                        |..|..|
Zfish   600 HDPPPAAVPCDTLTLSHLHQPNVTVSGLQGTNVTLDMPIPNATMMDQGLYACQVEIVGTNEKTCL 664

  Fly   248 ---------QPDEEVTPTTPVRIS---STTPKSRTKLTPI-----TANNSTRVESAIPAETTTPS 295
                     :....||..|..|::   |||.......||.     |.:|.|.:|.         |
Zfish   665 LHNLRLRALEMSRIVTNLTDQRVNVSDSTTLVCEVSGTPTPTIVWTKDNQTVMEG---------S 720

  Fly   296 GGHHNNSSSPITIFSLKSGTIPIVVTVGGFFVAIAVLLAYLCRRRLCAISRTLKKTKEKEELAKK 360
            |.....|:..:||..:|...       .|.::..|      |.::.|                 :
Zfish   721 GVILKRSNRVLTIQRVKKED-------SGLYICTA------CNQQGC-----------------E 755

  Fly   361 SNQSQLSSTLTDDSRN-SMVMQQWQGPVAFA------------NRYVPWERDQQMGIATSQLSTG 412
            |:::::|....::..| .::|.  .|.|..|            ||..|.:.|         |.||
Zfish   756 SSEARISVDGAEEKMNVELIMP--IGAVVIAMFLWLLIVFVIRNRKRPNDGD---------LKTG 809

  Fly   413 VTNGGVSSPGVPSPGTGEPGSNLGPGCLTGGAGSSGAPENAFAGEANCDR-------WEFPRYRL 470
            ..:..:.|..:|.                               :.:|:|       |||||.||
Zfish   810 YLSIILDSDDMPM-------------------------------DEHCERLTYDASKWEFPRDRL 843

  Fly   471 KFFNILGEGAFGQVWRCEATNINGNEGITTVAVKTLKESATEVDRKDLLSELEVMKSLEPHINVV 535
            |....||.||||||....|..|......||||||.|||.||..:.:.|:|||:::..:..|:|||
Zfish   844 KLGEPLGRGAFGQVVEATAYGIEKATTCTTVAVKMLKEGATSSEYRALMSELKILIHIGHHLNVV 908

  Fly   536 HLLGCCTDK-DPTFVILEYVNRGKLQTYLRSSRAE-----------------------RHYGNTH 576
            :|||.||.: .|..||:||...|.|.:||:|.|.|                       |......
Zfish   909 NLLGACTKQGGPLMVIVEYCKHGNLSSYLKSKRGEYSPYKKRTPRMPNRREVQQDEDPREGDLGL 973

  Fly   577 GKSNVLTSC--------------------------------DLTSFMYQVAKGMDYLTSRGIIHR 609
            |.|..|..|                                ||.|:.:||||||::|.||..|||
Zfish   974 GTSTRLDICTGTAVCTRTGEQTSTTLQDEQESSDWDHLTMEDLISYSFQVAKGMEFLASRKCIHR 1038

  Fly   610 DLAARNILITDDHTCKVADFGFARDVITSKIYERKSEGKLPIRWMATESLYDNIFSVKSDIWSFG 674
            ||||||||::::...|:.|||.||||.....|.||.:.:||::|||.|:::|.:::.:||:||||
Zfish  1039 DLAARNILLSENSVVKICDFGLARDVYKDPDYVRKGDARLPLKWMAPETIFDRVYTTQSDVWSFG 1103

  Fly   675 ILMWEIVTLGSTPYPGISAAD-VMRKVRDGYRLEKPEHCRRELYNIMYYCWSHDPQERPLFAEII 738
            :|:|||.:||::||||:...: ..|::::|.|:..|::...|:|..|..||...|.:||.|.:::
Zfish  1104 VLLWEIFSLGASPYPGVCIDESFCRRLKEGTRMRAPDYATPEIYQTMLDCWLDRPLDRPTFTQLV 1168

  Fly   739 QMLDKLLHTE-----MDYIEL 754
            :.|..||...     .|||.|
Zfish  1169 EHLGNLLQASAQQDGKDYIPL 1189

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637	22/107 (21%)
		STYKc	470..741	CDD:214568	123/327 (38%)
		PTKc	474..742	CDD:270623	121/324 (37%)
kdr	NP_001019824.2	Ig_2	143..221	CDD:290606
		IG_like	233..331	CDD:214653
		Ig	241..335	CDD:299845
		IG_like	345..429	CDD:214653	12/53 (23%)
		Ig2_VEGFR-2	356..429	CDD:143272	12/53 (23%)
		IG	571..654	CDD:214652	14/95 (15%)
		Ig	571..654	CDD:299845	14/95 (15%)
		I-set	677..763	CDD:254352	24/124 (19%)
		IGc2	691..753	CDD:197706	18/83 (22%)
		PKc_like	835..1178	CDD:304357	132/342 (39%)
		Pkinase_Tyr	843..1171	CDD:285015	123/327 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	944..975		1/30 (3%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1296..1357
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810