DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Ca and flt1

DIOPT Version :9

Sequence 1:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	NP_001014829.3	Gene:	flt1 / 544667	ZFINID:	ZDB-GENE-050407-1	Length:	1272	Species:	Danio rerio

Alignment Length:	938	Identity:	235/938 - (25%)
Similarity:	370/938 - (39%)	Gaps:	263/938 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 QLTSW-RRRSLLLTIIVVTATVVSLISQEAEAHNQNAPPI-LYVRERNWRISETEKV-------- 72
            |:||. .:|....|:||.....:.|       .::|.|.: .:..::::|::...|.
Zfish   304 QVTSGPSKRETNTTVIVYDQPFIRL-------KHRNGPVVQAFAGQKSFRLTPKLKAFPAPEIIW 361

  Fly    73 ---GQI-IDRVRAEDPDGDDLIFGIEPRFSLPGGENDASPPEKIPFQIDRETGVVTLNESLAGRA 133
               |.: .:|......||..|:.            .|.:         :.:.|:.|:   |.|..
Zfish   362 LKDGMVAAERCSRYHVDGFSLVI------------RDVA---------EEDAGIYTI---LTGIQ 402

  Fly   134 GQNFLIYITVTDGSYTAKNEVFINI---LGERENSSGYRP---QTSISNVVHNISQFLPRFDQLP 192
            .......:|:|         :.:|:   :||:..|| .:|   |......:|..|..:|.    |
Zfish   403 QYGLFQNLTIT---------LVVNVKPQIGEKSVSS-QQPGTVQRGSRQALHCTSHGVPP----P 453

  Fly   193 GVQSIRNGLPNSRPGGWYPPVPQNNIFGPPPFGNNYPPPPPNIPGVRGEQSGEEEQPDEEVTPTT 257
            .:|.:           |:|         .||.|....|||.:...|| :::|.....:..:|.:.
Zfish   454 QIQWL-----------WHP---------CPPKGLCEKPPPSSWTAVR-KKTGVTSTHNPILTISH 497

  Fly   258 PVRISSTTPKSRTKLTP-----------ITANNSTRVESAIPAETTTPSGG-------------- 297
            ...:.....|:...||.           :|:|...|.|..||...|....|
Zfish   498 RQEVLEGKNKTVGVLTVGEALVSGIYRCVTSNILGRDELDIPFYVTDVKEGLVASLVEEPREGGD 562

  Fly   298 --------HH-------NNSSSPITIFSLKSGTIPIVVTVGGFFVAIAVLLAYLCRR----RLCA 343
                    .|       :..:|.||::...|| :...:|.|.|...:...|..|..|    ..|:
Zfish   563 LRLLCIANRHLYSDLSWSRITSQITVWDEASG-LDGELTEGQFSHTLHFGLKNLTARDSGTYRCS 626

  Fly   344 ISRTLKKTKEKEELAKKSNQSQ---LSSTLTDDS------------------------RNSMVMQ 381
            .:..|.......:.|.:....|   |...|:|.:                        :|...:|
Zfish   627 ATHLLTGEHIHLDTAVEVTVLQAPVLLGNLSDHTVNVSNSITLHCPARGVPQPHITWYKNQRKLQ 691

  Fly   382 QWQGPVAFANR--------------YVPWERDQQMGIATSQLSTGVTNGGVS-SPGVPSPG---- 427
            |..|.:.|...              :...:...|.|...|.....|.|...| |..:|:..
Zfish   692 QVSGIMLFPEEGTLHIDRITVEDQGFYTCQATNQRGSVESSAYIWVQNSSESLSLEIPTLACTCV 756

  Fly   428 ---------------TGEPGSNLGPGCLTGGAGSSGAPENAFAGE----ANCDR-------WEFP 466
                           ...|.|:.|.        :...|.....||    .:|||       ||||
Zfish   757 VATLFWLLLTLLIRKLKHPNSDNGK--------AEYLPIILHPGEEPLVEHCDRLQYDPAKWEFP 813

  Fly   467 RYRLKFFNILGEGAFGQVWRCEATNINGNEGITTVAVKTLKESATEVDRKDLLSELEVMKSLEPH 531
            |.|||....||.||||:|.:..|..|..:...||||||.||:.||..:.|.|::||:::..:..|
Zfish   814 RDRLKLEKPLGRGAFGRVMQASAVGIGNSASCTTVAVKMLKDGATPSEHKALMTELKILNHIGHH 878

  Fly   532 INVVHLLGCCTDK-DPTFVILEYVNRGKLQTYLRSSR---------------------------- 567
            ||||:|||.||.. .|..||:||...|.|..||:|.|
Zfish   879 INVVNLLGACTKSGGPLMVIVEYCQFGNLSAYLKSKREVFLLNRVNKEEEGVMKEGCKGRLTSVS 943

  Fly   568 -----AERHYGNTHGK------------SNVLTSCDLTSFMYQVAKGMDYLTSRGIIHRDLAARN 615
                 |...:....|:            |:.|...||.|:.:|||:||::|.||..|||||||||
Zfish   944 SRQSNASSGFSEERGEISEEDSDCLSELSDPLLLEDLISYSFQVARGMEFLASRKCIHRDLAARN 1008

  Fly   616 ILITDDHTCKVADFGFARDVITSKIYERKSEGKLPIRWMATESLYDNIFSVKSDIWSFGILMWEI 680
            ||:::::..|:.|||.|||:.....|.|..:.:||::|||.||::|.:|:.:||:||:|:|:|||
Zfish  1009 ILLSNNNVVKICDFGLARDLYKDPDYVRNGDARLPLKWMAPESIFDKVFTTQSDVWSYGVLLWEI 1073

  Fly   681 VTLGSTPYPGISA-ADVMRKVRDGYRLEKPEHCRRELYNIMYYCWSHDPQERPLFAEIIQMLDKL 744
            .:||::||||::. .:..|:::.|.|:..|::...|:|:||..||.::|::||.|..::::|..|
Zfish  1074 FSLGASPYPGLNMDEEFCRRLKHGTRMCSPQYSTPEIYSIMCACWENNPEDRPSFTTLVEILGDL 1138

  Fly   745 LHT-----EMDYIELERFPDHNYYNIVS 767
            |.|     ..|||.|..|.....:.|.:
Zfish  1139 LQTCVQQDGKDYIPLNAFKSGEGHTITT 1166

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637	17/113 (15%)
		STYKc	470..741	CDD:214568	119/317 (38%)
		PTKc	474..742	CDD:270623	117/314 (37%)
flt1	NP_001014829.3	Ig	238..321	CDD:386229	6/16 (38%)
		Ig_VEGFR-1	345..416	CDD:143326	14/103 (14%)
		Ig_3	426..529	CDD:372822	25/128 (20%)
		IG	558..646	CDD:214652	15/88 (17%)
		I-set	650..733	CDD:369462	11/82 (13%)
		PTKc_VEGFR	809..1138	CDD:270647	126/328 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810