DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Ca and kitb

DIOPT Version :9

Sequence 1:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	NP_001137390.1	Gene:	kitb / 497629	ZFINID:	ZDB-GENE-050916-2	Length:	957	Species:	Danio rerio

Alignment Length:	734	Identity:	205/734 - (27%)
Similarity:	297/734 - (40%)	Gaps:	228/734 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 ETGVVTLNES----LAGRAGQNFLIYITVTDGSYTAKNEVFINILG-ERENSSGYRPQTSISNVV 178
            |.|.:.|.|.    :..|.|::..:.:.:|  ||...|:|...... |.:|:|        .:|:
Zfish   307 ERGFINLTEGENRVVEVREGESLTLSVEIT--SYPKPNDVLWTYNNQELQNTS--------EHVI 361

  Fly   179 --HN-----ISQFLPRFDQLPGVQSIRNGLPNSRPGGWYPPVPQN---NIFGPPPF--------- 224
              ||     ||:.     :|..|.....|:........|..|.|:   ::...|..
Zfish   362 TLHNQQYRYISEL-----RLVRVHGSEGGIYTFSANHKYESVNQSFTVHVICKPVIVSQEGPVDG 421

  Fly   225 -----GNNYPPP--------PPNIPGVRGEQSGEEEQPDEEVTPTTPVRISSTTPKSRTKLTPIT 276
                 .:.||.|        ||:   .|........|.|||                   ...||
Zfish   422 QVRCVASGYPVPKISWYYCEPPH---TRCSHLLNATQADEE-------------------FAVIT 464

  Fly   277 ANNSTRVESAIPAETTTPSGGHHN-------NSSSPITIFSLKSGTIP-----------IVVTVG 323
            .:.|....|.:.:......|..|.       ......|:||:...|:|           :..:|.
Zfish   465 VSGSEFGRSEVESRLNISKGKFHTLECVASAQGEQAYTLFSISERTVPHKLFTPLLSGVVSTSVL 529

  Fly   324 GFFVAIAVLLAYLCRRRLCAISRTLKKTKEKEELAKKSNQSQLSSTLTDDSRNSMVMQQWQGPVA 388
            ..|:.:.:|..|:              .|.|.|:..|                  |:..:.|
Zfish   530 LSFILVVLLYKYM--------------QKPKYEIHWK------------------VIDSFDG--- 559

  Fly   389 FANRYVPWERDQQMGIATSQLSTGVTNGGVSSPGVPSPGTGEPGSNLGPGCLTGGAGSSGAPENA 453
              |.|.        .|..:||           |..|
Zfish   560 --NNYT--------YIDPTQL-----------PYDP----------------------------- 574

  Fly   454 FAGEANCDRWEFPRYRLKFFNILGEGAFGQVWRCEATNINGNEGITTVAVKTLKESATEVDRKDL 518
                    :|||||.||:|..|||.||||:|....|..:...:.:||||||.||.||...:::.|
Zfish   575 --------KWEFPRERLRFGKILGSGAFGKVVAATAYGLCSADTVTTVAVKMLKPSAHSTEKEAL 631

  Fly   519 LSELEVMKSLEPHINVVHLLGCCTDKDPTFVILEYVNRGKLQTYLRSSR--------AERHY--- 572
            :|||:|:..:..|||:|:|||.||...||.||.||...|.|..:||..|        .:.:|
Zfish   632 MSELKVLSYIGNHINIVNLLGACTVGGPTLVITEYCCYGDLLNFLRRKRDAFFSSKTGDGYYKNL 696

  Fly   573 ---------GNTHG---------KSNVLTSC-----------DLTSFMYQVAKGMDYLTSRGIIH 608
                     |..:|         :||....|           ||.||.||||||||:|||:..||
Zfish   697 LSQTQPSIEGTDNGYMPMRSYQKRSNQTEWCDDKDDLSLDTEDLLSFSYQVAKGMDFLTSKNCIH 761

  Fly   609 RDLAARNILITDDHTCKVADFGFARDVITSKIYERKSEGKLPIRWMATESLYDNIFSVKSDIWSF 673
            |||||||:|:|.....|:.|||.|||:.....|..:...:||::||:.|||:..:::.:||:||:
Zfish   762 RDLAARNVLLTQGRVAKICDFGLARDITRDSNYVLRGNARLPVKWMSPESLFACVYTFESDVWSY 826

  Fly   674 GILMWEIVTLGSTPYPGISAADVMRK-VRDGYRLEKPEHCRRELYNIMYYCWSHDPQERPLFAEI 737
            |||:|||.:||:||||||.......| ::||||:.:||....|:|.:|.:|||.||.:||.|.::
Zfish   827 GILLWEIFSLGNTPYPGIPVGSTFYKMIQDGYRMSEPEFAPSEIYEVMRWCWSADPLKRPPFKKL 891

  Fly   738 IQMLDKLLH--TEMDYIEL 754
            ::..:.||.  |:.||:.|
Zfish   892 VERTELLLSETTKHDYLNL 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637	12/49 (24%)
		STYKc	470..741	CDD:214568	129/311 (41%)
		PTKc	474..742	CDD:270623	127/308 (41%)
kitb	NP_001137390.1	IG_like	121..201	CDD:214653
		Ig	209..305	CDD:299845
		IG	225..305	CDD:214652
		Ig	309..407	CDD:299845	24/112 (21%)
		I-set	319..406	CDD:254352	21/101 (21%)
		PKc_like	547..896	CDD:304357	146/427 (34%)
		Pkinase_Tyr	583..894	CDD:285015	129/310 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810