DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad96Ca and btl

DIOPT Version :9

Sequence 1:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster

Alignment Length:	1034	Identity:	271/1034 - (26%)
Similarity:	399/1034 - (38%)	Gaps:	349/1034 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YHHHNHESRIIHCRKQLT---SWRRRSLL----LTIIVV--------------TATVVSLISQEA 46
            |.||       .|...:|   |.|:|.||    :|:..|              .||::.|  :.|
  Fly    25 YGHH-------RCYIDVTVENSPRQRHLLSDMDITLQCVRPMAKWFYEDKFQLRATLLRL--ERA 80

  Fly    47 EAHNQNAPPILYVRERNWRIS----ETEKVG-QIIDRVRAED----PDGDDLIFG---------- 92
            ::.|......|..:.|.:.||    ..|.|| .|...|:.||    |: .||.|.
  Fly    81 QSGNSGNYGCLDSQNRWYNISLVVGHKEPVGNDIASFVKLEDAPALPE-SDLFFQPLNESRSLKL 144

  Fly    93 IEPRFSLP-------GG--ENDASPPEKIPFQIDRETGVVTLN------ESLAGRAGQNFLIYIT 142
            ::|   ||       ||  :.:.||       :|.:...|.::      :.|.|| |:..|...:
  Fly   145 LQP---LPKTVQRTAGGLFQLNCSP-------MDPDAKGVNISWLHNDTQILGGR-GRIKLKRWS 198

  Fly   143 VT--------DGSYTAK----------NEVFINILGEREN----SSGYRPQTSIS---NV----- 177
            :|        .|||..:          |...:.::..:..    ..||...|||:   ||
  Fly   199 LTVGQLQPEDAGSYHCELCVEQDCQRSNPTQLEVISRKHTVPMLKPGYPRNTSIALGDNVSIECL 263

  Fly   178 ------------VH-----NISQFLPRF---DQLP-----------GVQSIRNGLPNSRPGGWYP 211
                        :|     ||...|.|.   .|||           ..|.:|.|......||||.
  Fly   264 LEDSALEPKITWLHKGNADNIDDLLQRLREQSQLPVDVTRLITRMDEPQVLRLGNVLMEDGGWYI 328

  Fly   212 PVPQNNIFG---PPPFGNNYPP----------------PPPNIPGVRGEQSGEEEQPDEEVTPTT 257
            .:.:|.: |   ...:.:.|.|                |.|.      ..:||:...|.| .|..
  Fly   329 CIAENQV-GRTVAASYVDLYSPSDTTTVRTTTTTTVASPIPT------ASTGEDNDDDVE-NPAA 385

  Fly   258 PVRISSTTPKSRTKLTPI-------TAN---------NSTRVESAIP-----------------A 289
            ........|..|.:|..:       |.|         |.|..:...|                 .
  Fly   386 EASGGVGPPVFRKELKRLQHSLSGNTVNLACPVYGKANITWTKDKKPLNRELGVYVQKNWTLRFV 450

  Fly   290 ETTTPSGGHHN----NSSSPITI-FSL----KSGTIPIVVTVGGFFVAIAVLLAYLCR-----RR 340
            |.|:...|.:|    |:...|.. ||:    ::.:.||:|......|.:...|...|.     ..
  Fly   451 EATSEDSGLYNCKVCNAWGCIQFDFSVQINDRTRSAPIIVVPQNQTVKVNGSLVMKCTVYSDLHP 515

  Fly   341 LCAISRTLKKTKEKEELAKKSNQSQ-LSSTLTDDSRNSMVMQQWQGPVAFANRYVPWERDQQMGI 404
            ..:..|.:.|....:.|  ||.:.| |:.|:|:||            |....|.|.::   |.|.
  Fly   516 TVSWKRVVLKNASLDGL--KSVEIQNLNFTVTNDS------------VVLTLRNVTFD---QEGW 563

  Fly   405 ATSQLSTGVTNGGVSSPGV------PSP----------------------------GTG------ 429
            .|...|:|:   |.|:..|      |.|                            |:.
  Fly   564 YTCLASSGL---GRSNSSVYLRVVSPLPPLEIYALLHAHPLGFTLAAITIVALFLLGSAFITFML 625

  Fly   430 --------------------------EPGSNLGPGCLTG-------------------GAG---- 445
                                      .||...|.||.:|                   |.|
  Fly   626 RRLRREKLLKLRIETVHQWTKKVIIYRPGGEEGSGCSSGDLQMPVIRIEKQRTTVSTTGTGGTDP 690

  Fly   446 SSGAPENAFAGEANCDRWEFPRYRLKFFNILGEGAFGQVWRCEATNINGNEGI--------TTVA 502
            :.|..|..|..::|   ||.||.:|...:||||||||:|...||      ||:        |.||
  Fly   691 AQGFNEYEFPLDSN---WEIPRQQLSLGSILGEGAFGRVVMAEA------EGLPRSPQLAETIVA 746

  Fly   503 VKTLKESATEVDRKDLLSELEVMKSLEPHINVVHLLGCCTDKDPTFVILEYVNRGKLQTYLRSSR 567
            ||.:||..|:.|...|:.|:||||.:..|||:::|||||:...|.:||:||...|.|:.:|:.:|
  Fly   747 VKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNR 811

  Fly   568 --AERHYGNTHG--------KSNVLTSCDLTSFMYQVAKGMDYLTSRGIIHRDLAARNILITDDH 622
              |.:...::.|        .:..|...:||.|.:|:|:||:||.||..|||||||||:|::|.:
  Fly   812 PGAPQRRSDSDGYLDDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGY 876

  Fly   623 TCKVADFGFARDVITSKIYERKSEGKLPIRWMATESLYDNIFSVKSDIWSFGILMWEIVTLGSTP 687
            ..|:||||.|||:..::.|.:.:.|:|||:|||.|||.:..:..:||:||:|:|:|||:|.|..|
  Fly   877 VMKIADFGLARDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQP 941

  Fly   688 YPGI-SAADVMRKVRDGYRLEKPEHCRRELYNIMYYCWSHDPQERPLFAEIIQMLDKLL 745
            ||.| ||.::...:..|.|:|||..|...:|.:|..||..:...||.|||:::..|.:|
  Fly   942 YPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGIL 1000

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637	32/150 (21%)
		STYKc	470..741	CDD:214568	122/289 (42%)
		PTKc	474..742	CDD:270623	121/286 (42%)
btl	NP_001014583.1	IG_like	149..232	CDD:214653	17/90 (19%)
		IGc2	157..215	CDD:197706	15/65 (23%)
		IG	247..336	CDD:214652	21/89 (24%)
		Ig	258..340	CDD:143165	18/82 (22%)
		I-set	394..479	CDD:254352	16/84 (19%)
		IGc2	408..469	CDD:197706	10/60 (17%)
		IG_like	492..583	CDD:214653	25/110 (23%)
		Ig	507..583	CDD:299845	23/95 (24%)
		PKc_like	700..1000	CDD:304357	128/308 (42%)
		TyrKc	712..996	CDD:197581	122/289 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455242
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	1	0.900	-	-		E1_KOG0200
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.840